The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages

Autor: Tatjana Reuter, Ryosuke Hiranuma, Yusuke Murakami, Yuji Motoi, Eicke Latz, Kaiwen Liu, Ryutaro Fukui, Ryota Sato, Shin-ichiroh Saitoh, Kensuke Miyake, Hiroki Tsukamoto, Satoshi Yamazaki, Takuma Shibata

Publikováno v: International immunology 32(12), 785-798 (2020). doi:10.1093/intimm/dxaa055

Toll-like receptors (TLRs) impact myeloid cell responsiveness to environmental cues such as pathogen components and metabolites. Although TLR protein expression in monocytes and tissue macrophages is thought to be optimized for microenvironments in e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9042b9057ba4bfb7f1a6cb1807c4d25c
https://doi.org/10.1093/intimm/dxaa055

Investigating the Effect of Staphylococcus aureus Extracellular Vesicular-Packaged RNA on Human Gene Expression

Autor: Marino, Emily C.

Analyzing host cell response using RNA-seq allows us to understand what is happening within the host cell that could be missed by narrower analysis. From the analyses in this study, we can broadly state that extracellular vesicles (EVs) produced by S

Externí odkaz: http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1650625832811256

Inflammasome‐induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses

Autor: Budden, Christina F, Gearing, Linden J, Kaiser, Romina, Standke, Lena, Hertzog, Paul J, Latz, Eicke

Publikováno v: Journal of Extracellular Vesicles, Vol 10, Iss 10, Pp n/a-n/a (2021)
Journal of Extracellular Vesicles
Journal of extracellular vesicles 10(10), e12127 (2021). doi:10.1002/jev2.12127

Infectious organisms and damage of cells can activate inflammasomes, which mediate tissue inflammation and adaptive immunity. These mechanisms evolved to curb the spread of microbes and to induce repair of the damaged tissue. Chronic activation of in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6cb0461183032a12f2e0deda81667764
https://doaj.org/article/656533e82de9493cb7c7b1110c12fae3

CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer

Autor: Erik R. Nelson, Yiquin Jiao, Scott A. Lawrence, Amy E. Baek, Donald P. McDonnell, Ching-Yi Chang, Debarati Mukherjee, William Lento, William J. Zuercher, Brian York, David H. Drewry, Anna Maria Masci, Joseph Geradts, Allison Hall, Francesca Romana Bertani, Wei Huang, Luigi Racioppi, Nelson J. Chao, Luca Businaro, Sunghee Park, Anthony R. Means, Yaping Liu

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature communications 10 (2019). doi:10.1038/s41467-019-10424-5
info:cnr-pdr/source/autori:Racioppi, Luigi; Nelson, Erik R.; Huang, Wei; Mukherjee, Debarati; Lawrence, Scott A.; Lento, William; Masci, Anna Maria; Jiao, Yiquin; Park, Sunghee; York, Brian; Liu, Yaping; Baek, Amy E.; Drewry, David H.; Zuercher, William J.; Bertani, Francesca R.; Businaro, Luca; Geradts, Joseph; Hall, Allison; Means, Anthony R.; Chao, Nelson; Chang, Ching-yi; McDonnell, Donald P./titolo:CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer/doi:10.1038%2Fs41467-019-10424-5/rivista:Nature communications/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:10

Tumor-associated myeloid cells regulate tumor growth and metastasis, and their accumulation is a negative prognostic factor for breast cancer. Here we find calcium/calmodulin-dependent kinase kinase (CaMKK2) to be highly expressed within intratumoral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ab4a370fb2e5fc93f96678b7994698
https://doaj.org/article/072c9c0330034d37ac61bcbbffebcda1

A Population of Radio-Resistant Macrophages in the Deep Myenteric Plexus Contributes to Postoperative Ileus Via Toll-Like Receptor 3 Signaling

Autor: Jana Enderes, Shilpashree Mallesh, Reiner Schneider, Kristof J. Hupa, Mariola Lysson, Bianca Schneiker, Kristian Händler, Balthasar Schlotmann, Patrick Günther, Joachim L. Schultze, Jörg C. Kalff, Sven Wehner

Publikováno v: Frontiers in Immunology, Vol 11 (2021)
Frontiers in immunology 11, 581111 (2021). doi:10.3389/fimmu.2020.581111

Postoperative ileus (POI) is triggered by an innate immune response in the muscularis externa (ME) and is accompanied by bacterial translocation. Bacteria can trigger an innate immune response via toll-like receptor (TLR) activation, but the latter�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d7e5b71452e66799627b2f4a685bb3
https://doi.org/10.3389/fimmu.2020.581111