Lung T cell response in COVID-19

Autor: Mehrnoush Hadaddzadeh Shakiba, Ioanna Gemünd, Marc Beyer, Lorenzo Bonaguro

Publikováno v: Frontiers in immunology 14, 1108716 (2023). doi:10.3389/fimmu.2023.1108716

The COVID-19 pandemic has shown the potentially devastating impact of novel respiratory infections worldwide. Insightful data obtained in the last years have shed light on the pathophysiology of SARS-CoV-2 infection and the role of the inflammatory r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a8a306f6c013eb558d14323dcd38e3

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Autor: Georg, Philipp, Astaburuaga-García, Rosario, Demichev, Vadim, Gemünd, Ioanna Dafni, Barone, Matthias, Tober-Lau, Pinkus, Helbig, Elisa T, Hillus, David, Petrov, Lev, Stein, Julia, Dey, Hannah-Philine, Paclik, Daniela, Bonaguro, Lorenzo, Iwert, Christina, Mülleder, Michael, Aulakh, Simran Kaur, Djudjaj, Sonja, Bülow, Roman D, Mei, Henrik E, Schulz, Axel R, Thiel, Andreas, Hippenstiel, Stefan, Saliba, Antoine-Emmanuel, Brumhard, Sophia, Eils, Roland, Lehmann, Irina, Mall, Marcus A, Stricker, Sebastian, Röhmel, Jobst, Corman, Victor, Beule, Dieter, Wyler, Emanuel, Landthaler, Markus, Obermayer, Benedikt, Michalick, Laura, von Stillfried, Saskia, Boor, Peter, Demir, Münevver, Wesselmann, Hans, Suttorp, Norbert, Uhrig, Alexander, Müller-Redetzky, Holger, Nattermann, Jacob, Kuebler, Wolfgang M, Meisel, Christian, Lippert, Lena J, Ralser, Markus, Schultze, Joachim L, Aschenbrenner, Anna C, Thibeault, Charlotte, Kurth, Florian, Sander, Leif E, Blüthgen, Nils, Sawitzki, Birgit, Group, PA-COVID-19 Study, Kostevc, Tomislav, Gäbel, Christiane, Schneider, Maria, Streitz, Mathias

Publikováno v: Cell 185(3), 493-512.e25 (2022). doi:10.1016/j.cell.2021.12.040
Cell
512.e25
United Kingdom
United States

Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathology, and it remains unclear whether T cells contribute to disease pathology. Here, we combined single-cell transcriptomics and single-cell proteomics with me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c6da7a71d7b52732dd04eff36b762e
https://pub.dzne.de/record/164035

Monocytes and Macrophages in COVID-19

Autor: Rainer Knoll, Joachim L. Schultze, Jonas Schulte-Schrepping

Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Frontiers in immunology 12, 720109 (2021). doi:10.3389/fimmu.2021.720109
Frontiers in Immunology

COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing pandemic with massive global health and socioeconomic consequences. The disease is characterized primarily, but not exclusively, by respiratory clinical manifestations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0341d35310e2fb57fc579d76265ce72a
https://doi.org/10.3389/fimmu.2021.720109

COVID-19 and the human innate immune system

Autor: Joachim L. Schultze, Anna C. Aschenbrenner

Publikováno v: Cell 184(7), 1671-1692 (2021). doi:10.1016/j.cell.2021.02.029
Cell

The introduction of SARS-CoV-2 into the human population represents a tremendous medical and economical crisis. Innate immunity - as the first line of defense of our immune system - plays a central role in combating this novel virus. Here, we provide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d186acd60eae7f814a34f113919d76d4
https://pub.dzne.de/record/154638

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

Autor: Jan Heyckendorf, Elisa Rosati, Jens Stoye, Andreas Dräger, Alex K. Shalek, Daniela Bezdan, Norbert Frey, Ulisses Nunes da Rocha, Thomas Bahmer, Simon Imm, Antoine-Emmanuel Saliba, Markus Landthaler, Ezio Bonifacio, Maria Colme-Tatche, Annika Schaffarzyk, Alexander Sczyrba, Dora Bordoni, David Ellinghaus, Christoph Lange, Stefan Janssen, Nicholas E. Banovich, Laure-Emmanuelle Zaragosi, Markus M. Nöthen, Anette Friedrichs, Alexander M. Tsankov, Teide Boysen, Andreas Glück, Philipp H. Schiffer, Lena Best, Oliver Eickelberg, Silke Peter, Nathan Baran, Maarten van den Berge, Oliver Kohlbacher, Anna R. Poetsch, Michael Hummel, Ulf Geisen, Dagmar Wieczorek, Alexander T. Dilthey, Burkhard Brandt, Kerstin B. Meyer, Christian Mertes, Jonas Schulte-Schrepping, Florian Tran, Birgit Sawitzki, Hauke Busch, Christoph Klein, Christos Samakovlis, Niklaus Rajewsky, Joachim Schultze, Sören Franzenburg, Jörn Walter, Sina Kaiser, Jörg Vogel, Niklas Bruse, Marc P. Hoeppner, Muzlifa Haniffa, Alina Renz, Purushothama Rao Tata, Stephan Ripke, Ralf Junker, Michael von Papen, Jonathan A. Kropski, Max von Kleist, Oliver Stegle, Neha Mishra, Jörg Overmann, Johanna I. Blase, Nicole Fischer, Jeffrey A. Whitsett, Sarah A. Teichmann, Birte Kehr, Domagoj Schunk, Julia Fischer, Andreas Diefenbach, Joakim Lundeberg, Matthijs Kox, Klaus-Peter Wandinger, Michael Forster, Ingo Kurth, Johannes Zimmermann, Yang Li, René Kallies, Petra Bacher, Torsten Hain, Joachim L. Schultze, Clemens Lier, Klaus Pfeffer, Michael Wittig, Jacob Nattermann, Paul A. Reyfman, Peter Nürnberg, Alfred Pühler, Andre Franke, Markus Ralser, Peter Pickkers, Andreas Keller, Matthias Lindner, Philipp Köhler, Dana Pe'er, Gunnar Elke, Jan Rybniker, Jonathan Josephs-Spaulding, Alexander Goesmann, Anke Becker, Aviv Regev, Ying H. Kan, Alexander Bartholomäus, Rainer Noth, Jonathan Dörr, Julia-Stefanie Frick, Stephan Ossowski, Bimba F. Hoyer, Peter Horvath, Jose Ordovas Montanes, Dirk Skowasch, Philip Rosenstiel, Georg Laue, Oliwia Makarewicz, Stefan Schreiber, Alexander Scheffold, Christoph Röcken, Leif E. Sander, Manja Marz, Joana P. Bernardes, Jörn Kalinowski, Uwe Ohler, Robert Markewitz, Jason R. Spence, Robert Lafyatis, Thomas Ulas, Peer Bork, Tushar J. Desai, Janne Vehreschild, Janina Fuß, Olaf Rieß, Robert Bals, Klaus F. Rabe, Jacob Hamm, Martijn C. Nawijn, John Ziebuhr, Angel Angelov, Fabian J. Theis, Rainer Knoll, Jan O. Korbel, Thomas Clavel, Konrad U. Förstner, Jan Rupp, Sarah Kim-Hellmuth, Christoph Kaleta, Alice C. McHardy, Anna C. Aschenbrenner, Emma L. Rawlins, Douglas P. Shepherd, Julien Gagneur, Marko Nikolic, Georgios Marinos, Jeanette Franzenburg, Eva-Christina Schulte, Axel Künstner, Andreas Walker, Finn Hinrichsen, Kerstin U. Ludwig

Publikováno v: Immunity, 53, 1296-1314.e9
Immunity, 53(6), 1296-1314.e9. CELL PRESS
Immunity 53(6), 1296-1314.e9 (2020). doi:10.1016/j.immuni.2020.11.017
Immunity
Immunity, 53, 6, pp. 1296-1314.e9
1314.e9
United States

Temporal resolution of cellular features associated with a severe COVID-19 disease trajectory is required for understanding skewed immune responses and finding outcome predictors. Here, we performed a longitudinal multi-omics study using a two-centre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9ae7fbbaa61a6ed5bec38333230f7e
https://doi.org/10.1016/j.immuni.2020.11.017