Zobrazeno 1 - 10
of 10
pro vyhledávání: '"immunology [Amyloid beta-Peptides]"'
Publikováno v:
Immunology & cell biology 98(1), 28-41 (2019). doi:10.1111/imcb.12301
Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology and neuroinflammation. Recently, there has been considerable interest in the role of neuroinflammation in directly contributing to the progression of AD. Stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7712671eb4cc79869a33f467f1eb25
https://doi.org/10.1111/imcb.12301
https://doi.org/10.1111/imcb.12301
Autor:
Wirths, Oliver, Walter, Susanne, Kraus, Inga, Klafki, Hans W., Stazi, Martina, Oberstein, Timo J., Ghiso, Jorge, Wiltfang, Jens, Bayer, Thomas A., Weggen, Sascha
Publikováno v:
Alzheimer's research & therapy 9(1), 80 (2017). doi:10.1186/s13195-017-0309-z
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-12 (2017)
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-12 (2017)
Alzheimer's Research & Therapy
Background The deposition of neurotoxic amyloid-β (Aβ) peptides in plaques in the brain parenchyma and in cerebral blood vessels is considered to be a key event in Alzheimer’s disease (AD) pathogenesis. Although the presence and impact of full-le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ff885ce55204eefef9daf60f129cc9d5
http://resolver.sub.uni-goettingen.de/purl?gs-1/15154
http://resolver.sub.uni-goettingen.de/purl?gs-1/15154
Autor:
Kronimus, Yannick, Albus, Alexandra, Liepelt-Scarfone, Inga, Gräber-Sultan, Susanne, Schulte, Claudia, Klockgether, Thomas, Wüllner, Ullrich, Balzer-Geldsetzer, Monika, Straub, Sarah, Semler, Elisa, Otto, Markus, Klotsche, Jens, Dodel, Richard, Consortium, LANDSCAPE, Mengel, David
Publikováno v:
PLoS ONE
PLOS ONE 11(11), e0164953 (2016). doi:10.1371/journal.pone.0164953
PLOS ONE 11(11), e0164953 (2016). doi:10.1371/journal.pone.0164953
Background and Objective Altered levels of naturally occurring autoantibodies (nAbs) against disease-associated neuronal proteins have been reported for neurodegenerative diseases, such as Alzheimer's (AD) and Parkinson's disease (PD). Recent histopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb7226f5bb462b6016eaa2de809ea9d
http://europepmc.org/articles/PMC5089716
http://europepmc.org/articles/PMC5089716
Autor:
Markus Langkamp, Daniela Berg, Thomas Gasser, Jana Godau, Stephanie C. Hörnig, Kathrin Brockmann, Matthis Synofzik, Walter Maetzler, Arthur Melms
Publikováno v:
Journal of Alzheimer's disease 26(1), 171-179 (2011). doi:10.3233/JAD-2011-110221
There is increasing evidence that in Lewy body-associated dementias (encompassing Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB)), the adaptive immune system is altered and the degenerative process includes glial cells in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0fbfc898e4c853a930d5061eb50e70
https://doi.org/10.3233/jad-2011-110221
https://doi.org/10.3233/jad-2011-110221
Autor:
Balakrishnan, Karthikeyan, Rijal Upadhaya, Ajeet, Steinmetz, Julia, Reichwald, Julia, Abramowski, Dorothee, Fändrich, Marcus, Kumar, Sathish, Yamaguchi, Haruyasu, Walter, Jochen, Staufenbiel, Matthias, Thal, Dietmar Rudolf
Publikováno v:
Acta Neuropathologica Communications 3(1), 41 (2015). doi:10.1186/s40478-015-0217-z
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Introduction The deposition of the amyloid β protein (Aβ) in the brain is a hallmark of Alzheimer's disease (AD). Removal of Aβ by Aβ-antibody treatment has been developed as a potential treatment strategy against AD. First clinical trials showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::682302b0fdf915d0766ea2f140435151
https://pub.dzne.de/record/138084
https://pub.dzne.de/record/138084
Publikováno v:
Nature reviews / Immunology 14(7), 463-477 (2014). doi:10.1038/nri3705
The triggering of innate immune mechanisms is emerging as a crucial component of major neurodegenerative diseases. Microglia and other cell types in the brain can be activated in response to misfolded proteins or aberrantly localized nucleic acids. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233cec8d7546baae367f6d97fb473057
https://pubmed.ncbi.nlm.nih.gov/24962261
https://pubmed.ncbi.nlm.nih.gov/24962261
Autor:
Maetzler, Walter, Apel, Anja, Langkamp, Markus, Deuschle, Christian, Dilger, Sarah Selina, Stirnkorb, Johannes Georg, Schulte, Claudia, Schleicher, Erwin, Gasser, Thomas, Berg, Daniela
Publikováno v:
PLoS ONE
PLOS ONE 9(2), e88604 (2014). doi:10.1371/journal.pone.0088604
PLoS ONE.-San Francisco : PloS one; 2014.-S.e88604:1-e88604:6.
PLoS ONE, Vol 9, Iss 2, p e88604 (2014)
PLOS ONE 9(2), e88604 (2014). doi:10.1371/journal.pone.0088604
PLoS ONE.-San Francisco : PloS one; 2014.-S.e88604:1-e88604:6.
PLoS ONE, Vol 9, Iss 2, p e88604 (2014)
Naturally occurring autoantibodies (NAbs) against a number of potentially disease-associated cellular proteins, including Amyloid-beta1-42 (Abeta1-42), Alpha-synuclein (Asyn), myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ec0c8d81a24b6987c30a442e0ab184d5
http://europepmc.org/articles/PMC3931625
http://europepmc.org/articles/PMC3931625
Autor:
Uwe Horn, Damian C. Crowther, Marcus Fändrich, Raik Rönicke, Christopher M. Dobson, Leila M. Luheshi, Klaus G. Reymann, Melanie Wulff, Martin Westermann, Jessica Wacker
Publikováno v:
Acta Neuropathologica Communications 2(1), 43 (2014). doi:10.1186/2051-5960-2-43
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Introduction The self-assembly of Aβ peptides into a range of conformationally heterogeneous amyloid states represents a fundamental event in Alzheimer’s disease. Within these structures oligomeric intermediates are considered to be particularly p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0def00ffff2361063422c5e884ea15
Autor:
Petra Füger, Angelos Skodras, Tsuyoshi Hamaguchi, Ulrike Obermüller, Claudia Schäfer, Yvonne S. Eisele, Mathias Jucker, Sarah K. Fritschi, Matthias Staufenbiel, Mathias Heikenwalder, Jörg Odenthal
Publikováno v:
The Journal of Neuroscience, 34, 10264-73
The journal of neuroscience 34(31), 10264-10273 (2014). doi:10.1523/JNEUROSCI.1608-14.2014
J. Neurosci. 34, 10264-10273 (2014)
The Journal of Neuroscience, 34, 31, pp. 10264-73
The journal of neuroscience 34(31), 10264-10273 (2014). doi:10.1523/JNEUROSCI.1608-14.2014
J. Neurosci. 34, 10264-10273 (2014)
The Journal of Neuroscience, 34, 31, pp. 10264-73
Contains fulltext : 135971.pdf (Publisher’s version ) (Open Access) Deposition of aggregated amyloid-beta (Abeta) peptide in brain is an early event and hallmark pathology of Alzheimer's disease and cerebral Abeta angiopathy. Experimental evidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc761526b355fae35a63a5ce6a2acb7
http://hdl.handle.net/2066/135971
http://hdl.handle.net/2066/135971
Autor:
Marianne K. O. Grant, Julia Steffen, Neng Wei Hu, Sonia Do Carmo, Igor Klyubin, Michael J. Rowan, A. Claudio Cuello, William K. Cullen, Yingjie Qi, Sarah C. Harney, Edward N. Wilson, Martin Fuhrmann, Karen H. Ashe, Stefan Remy
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications 2(1), 175 (2014). doi:10.1186/s40478-014-0175-x
Acta Neuropathologica Communications 2(1), 175 (2014). doi:10.1186/s40478-014-0175-x
Long before synaptic loss occurs in Alzheimer's disease significant harbingers of disease may be detected at the functional level. Here we examined if synaptic long-term potentiation is selectively disrupted prior to extracellular deposition of Aß i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436a88a6d2c33bda55895616daf51f72