Výsledky vyhledávání - "immunology, Antigens"

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

Autor: Nicholas C. Wu, Xueyong Zhu, Marit J. van Gils, Jakob Kreye, Chang-Chun D Lee, Linghang Peng, Hejun Liu, Meng Yuan, Abigail M. Jackson, Dennis R. Burton, Andrew B. Ward, Rogier W. Sanders, David Nemazee, S. Momsen Reincke, Harald Prüss, Ian A. Wilson, Deli Huang

Publikováno v: Science 373(6556), 818-823 (2021). doi:10.1126/science.abh1139
bioRxiv
article-version (status) pre
article-version (number) 1
Science, 373(6556), 818-823. American Association for the Advancement of Science
Science (New York, N.y.)

The protective efficacy of neutralizing antibodies (nAbs) elicited during natural infection with SARS-CoV-2 and by vaccination based on its spike protein has been compromised with emergence of the recent SARS-CoV-2 variants. Residues E484 and K417 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a44f112f84d84b18800a45c2c75d8b9
http://www.scopus.com/inward/record.url?scp=85112522453&partnerID=8YFLogxK

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Akademický článek

Efeitos da radiação solar crônica prolongada sobre o sistema imunológico de pescadores profissionais em Recife (PE), Brasil Effects of long-term chronic exposure to sun radiation in immunological system of commercial fishermen in Recife, Brazil

Autor: Sarita Maria de Fátima Martins de Carvalho Bezerra, Mirian Nakagami Sotto, Noemia Mie Orii, Cleiton Alves, Alberto José da Silva Duarte

Publikováno v: Anais Brasileiros de Dermatologia, Vol 86, Iss 2, Pp 222-233 (2011)

FUNDAMENTOS: Existe um consenso de que a exposição à radiação ultravioleta determina alterações n o sistema imunológico da pele, o que permite que se avente a hipótese de que a exposição prolongada e crônica ao Sol pode representar uma da

Externí odkaz: https://doaj.org/article/3300982609d244d8b8a431aecb7af886

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Discrepancies in the Tumor Microenvironment of Spontaneous and Orthotopic Murine Models of Pancreatic Cancer Uncover a New Immunostimulatory Phenotype for B Cells

Autor: Frances R. Balkwill, Jacqueline McDermott, Hemant M. Kocher, Cristina Ghirelli, Melania Capasso, Eleni Maniati, Sarah Spear, Juliana Candido, Stephen A. Beers

Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in immunology 10, 542 (2019). doi:10.3389/fimmu.2019.00542

B cells are salient features of pancreatic ductal adenocarcinoma (PDAC) tumors, yet their role in this disease remains controversial. Murine studies have indicated a protumoral role for B cells, whereas clinical data show tumor-infiltrating B cells a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295106d4c37166333e0efd16851ce340
https://doi.org/10.3389/fimmu.2019.00542

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A Luciferase Gene Driven by an Alphaherpesviral Promoter Also Responds to Immediate Early Antigens of the Betaherpesvirus HCMV, Allowing Comparative Analyses of Different Human Herpesviruses in One Reporter Cell Line

Autor: Anna Katharina Maier, Raimund Jung, Clarissa Villinger, Axel Schubert, Paul Walther, Christian Sinzger, Diana Lieber

Publikováno v: PLoS ONE
PLOS ONE 12(1), e0169580 (2017). doi:10.1371/journal.pone.0169580
PLoS ONE, Vol 12, Iss 1, p e0169580 (2017)

Widely used methods for quantification of human cytomegalovirus (HCMV) infection in cell culture such as immunoblotting or plaque reduction assays are generally restricted to low throughput and require time-consuming evaluation. Up to now, only few H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b046a292af88a7b002d95dfaaeb36394
http://europepmc.org/articles/PMC5217978

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High prevalence of neuronal surface autoantibodies associated with cognitive deficits in cancer patients

Autor: Lutz Harms, Frederik Bartels, Carsten Finke, Harald Prüss, Alva Lütt

Publikováno v: Journal of neurology 264(9), 1968-1977 (2017). doi:10.1007/s00415-017-8582-0

The recent discovery of neuronal cell-surface antibodies profoundly expanded the clinical spectrum of paraneoplastic neurological syndromes. Many of these syndromes are associated with impaired cognitive function, a clinical symptom that is of increa

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[Clinical Phenomenology of Autoimmune Encephalitis]

Autor: Holle, J. F., Jessen, F., Kuhn, J.

Publikováno v: Fortschritte der Neurologie, Psychiatrie 84(05), 271-280 (2016). doi:10.1055/s-0042-104194

Antibody-associated disorders of the central nervous system constitute a heterogeneous group of disorders that can be roughly divided into two categories: Classic paraneoplastic syndromes associated with so-called well-characterized antibodies (paran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10678::408205bd76eca77df59b9181d4e2f7af
https://pub.dzne.de/record/138641

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Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance

Autor: Kristine M. Garza, Linh T. Nguyen, Stephen P. Schoenberger, Kiichi Murakami, Bernhard Odermatt, Alisha R. Elford, Daniel E. Speiser, Pamela S. Ohashi

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 195, no. 4, pp. 423-35

Using a tumor model of spontaneously arising insulinomas expressing a defined tumor-associated antigen, we investigated whether tumor growth promotes cross-presentation and tolerance of tumor-specific T cells. We found that an advanced tumor burden e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e366766de521a6b014d251a43aff10
http://europepmc.org/articles/PMC2193619

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Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivax

Autor: Eleanor M. Riley, Chaisuree Suphavilai, Kanitta Thaikla, Jiraprapa Wipasa, Jackie Cook, Lucy C Okell, Julius C. R. Hafalla, Patrick H. Corran, Witaya Liewsaree

Publikováno v: PLoS Pathogens, Vol 6, Iss 2, p e1000770 (2010)
PLoS Pathogens
e1000770

Antibodies constitute a critical component of the naturally acquired immunity that develops following frequent exposure to malaria. However, specific antibody titres have been reported to decline rapidly in the absence of reinfection, supporting the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c102f6db3cdee6b823b67a24f511f08e
https://researchonline.lshtm.ac.uk/id/eprint/1992/1/ppat.1000770.pdf

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Boosting anti-idiotype immune response with recombinant AAV enhances tumour protection induced by gene gun vaccination

Autor: L Zentilin, Mauro Giacca, M. Cesco-Gaspere, Oscar R. Burrone

Thanks to the safety of administration, efficiency of in vivo transduction and persistence of transgene expression, vectors based on the adeno-associated virus (AAV) are extensively utilized in both preclinical and clinical experimentation. Here we t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bbafe0039713655ec6a968f7df2bb3
https://hdl.handle.net/11368/2493578

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Identification of a conserved region of Plasmodium falciparum MSP3 targeted by biologically active antibodies to improve vaccine design

Autor: Michael Theisen, Pierre Druilhe, Juan-Pedro Mejia, Christian Roussilhon, Soe Soe, Subhash Singh, Giampietro Corradin

Publikováno v: Journal of Infectious Diseases, vol. 190, no. 5, pp. 1010-8

Merozoite surface protein 3 (MSP3) is a target of antibody-dependent cellular inhibition (ADCI), a protective mechanism against Plasmodium falciparum malaria. From the C-terminal half of the molecule, 6 overlapping peptides were chosen to characteriz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b563b32573c4dfd604a757875051afe3
https://pubmed.ncbi.nlm.nih.gov/15295710

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