Zobrazeno 1 - 10
of 2 832
pro vyhledávání: '"immuno oncology"'
Autor:
Aryeh Silver, Avirup Chakraborty, Avinash Pittu, Diana Feier, Miruna Anica, Illeana West, Matthew R. Sarkisian, Loic P. Deleyrolle
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 4337-4349 (2024)
Analyzing the local microenvironment of tumor cells can provide significant insights into their complex interactions with their cellular surroundings, including immune cells. By quantifying the prevalence and distances of certain immune cells in the
Externí odkaz:
https://doaj.org/article/3dea6623cf6e45b49db2b877a92aeca9
Autor:
Anthony M. Brade, Houda Bahig, Andrea Bezjak, Rosalyn A. Juergens, Charmaine Lynden, Nicolas Marcoux, Barbara Melosky, Devin Schellenberg, Stephanie Snow
Publikováno v:
Current Oncology, Vol 31, Iss 11, Pp 6512-6535 (2024)
The addition of durvalumab consolidation to concurrent chemoradiation therapy (cCRT) has fundamentally changed the standard of care for patients with unresectable stage III non-small-cell lung cancer (NSCLC). Nevertheless, concerns related to esophag
Externí odkaz:
https://doaj.org/article/087c9780037e447f9a9b9b1899dd6af5
Publikováno v:
Immuno-Oncology and Technology, Vol 24, Iss , Pp 100739- (2024)
Chimeric antigen receptor (CAR)-T-cell therapy has emerged as a powerful weapon in the fight against cancer. However, its efficacy is often hindered by challenges such as limited tumor penetration, antigen escape, and immune suppression within the tu
Externí odkaz:
https://doaj.org/article/d1d97d9550a64a898b5c949b76ae5089
Autor:
Tove Selvin, Malin Berglund, Anders Åkerström, Marco Zia, Jakob Rudfeldt, Malin Jarvius, Rolf Larsson, Claes R Andersson, Mårten Fryknäs
Publikováno v:
SLAS Technology, Vol 29, Iss 6, Pp 100232- (2024)
To facilitate the translation of immunotherapies from bench to bedside, predictive preclinical models are essential. We developed the in vivo immuno-oncology Hollow Fiber Assay (HFA) to bridge the gap between simpler cell-based in vitro assays and mo
Externí odkaz:
https://doaj.org/article/d2e6640e28ad4e36aa4dfe94b2089f19
Delineating the nexus between gut-intratumoral microbiome and osteo-immune system in bone metastases
Publikováno v:
Bone Reports, Vol 23, Iss , Pp 101809- (2024)
Emerging insights in osteoimmunology have enabled researchers to explore in depth the role of immune modulation in regulating bone health. Bone is one of the common sites of metastasis notably in case of breast cancer, prostate cancer and several oth
Externí odkaz:
https://doaj.org/article/4196d6e425fc44398e21839f9f73dfb7
Autor:
Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny, Laura von Schantz
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Despite the large number of existing bispecific antibody (bsAb) formats, the generation of novel bsAbs is still associated with development and bioprocessing challenges. Here, we present RUBY, a novel bispecific antibody format that allows rapid gene
Externí odkaz:
https://doaj.org/article/3554ed116f6c45079b118217d1d8fd6f
Autor:
Diana I. Albu, Benjamin J. Wolf, Yan Qin, Xianzhe Wang, Amy Daniel Ulumben, Mei Su, Vivian Li, Eirene Ding, Jose Angel Gonzalo, Jason Kong, Ruturaj Jadhav, Nelly Kuklin, Alberto Visintin, Bing Gong, Thomas J. Schuetz
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Combinatorial strategies, such as targeting different immune checkpoint receptors, hold promise to increase the breadth and duration of the response to cancer therapy. Here we describe the preclinical evaluation of CTX-8371, a protein construct which
Externí odkaz:
https://doaj.org/article/5e1ca35cffdd474daf5caef1c125a47e
Autor:
Ramiro Martinez, Chiara Finocchiaro, Louis Delhaye, Fien Gysens, Jasper Anckaert, Wim Trypsteen, Maarten Versteven, Eva Lion, Sandra Van Lint, Karim Vermaelen, Eric James de Bony, Pieter Mestdagh
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cancer cells effectively evade immune surveillance, not only through the well-known PD-1/PD-L1 pathway but also via alternative mechanisms that impair patient response to immune checkpoint inhibitors. We present a novel co-culture model that pairs a
Externí odkaz:
https://doaj.org/article/49b655d42ec24ce69326b7dd266ba321
Autor:
Joaquim Carreras, Naoya Nakamura
Publikováno v:
Hemato, Vol 5, Iss 2, Pp 119-143 (2024)
Background: Artificial intelligence in medicine is a field that is rapidly evolving. Machine learning and deep learning are used to improve disease identification and diagnosis, personalize disease treatment, analyze medical images, evaluate clinical
Externí odkaz:
https://doaj.org/article/acfd57d3848140e8be0c4b638bb84d28
Autor:
Eric S. Nealy, Steven J. Reed, Steven M. Adelmund, Barry A. Badeau, Jared A. Shadish, Emily J. Girard, Kenneth Brasel, Fiona J. Pakiam, Andrew J. Mhyre, Jason P. Price, Surojit Sarkar, Vandana Kalia, Cole A. DeForest, James M. Olson
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 5, Pp n/a-n/a (2024)
Abstract Hydrogels are extensively employed in healthcare due to their adaptable structures, high water content, and biocompatibility, with FDA‐approved applications ranging from spinal cord regeneration to local therapeutic delivery. However, clin
Externí odkaz:
https://doaj.org/article/f56acf1e06fc4325af0d64c74915f5ee