Zobrazeno 1 - 10
of 2 799
pro vyhledávání: '"immuno‐oncology"'
Autor:
Ramiro Martinez, Chiara Finocchiaro, Louis Delhaye, Fien Gysens, Jasper Anckaert, Wim Trypsteen, Maarten Versteven, Eva Lion, Sandra Van Lint, Karim Vermaelen, Eric James de Bony, Pieter Mestdagh
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cancer cells effectively evade immune surveillance, not only through the well-known PD-1/PD-L1 pathway but also via alternative mechanisms that impair patient response to immune checkpoint inhibitors. We present a novel co-culture model that pairs a
Externí odkaz:
https://doaj.org/article/49b655d42ec24ce69326b7dd266ba321
Autor:
Eric S. Nealy, Steven J. Reed, Steven M. Adelmund, Barry A. Badeau, Jared A. Shadish, Emily J. Girard, Kenneth Brasel, Fiona J. Pakiam, Andrew J. Mhyre, Jason P. Price, Surojit Sarkar, Vandana Kalia, Cole A. DeForest, James M. Olson
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 5, Pp n/a-n/a (2024)
Abstract Hydrogels are extensively employed in healthcare due to their adaptable structures, high water content, and biocompatibility, with FDA‐approved applications ranging from spinal cord regeneration to local therapeutic delivery. However, clin
Externí odkaz:
https://doaj.org/article/f56acf1e06fc4325af0d64c74915f5ee
Autor:
Iulia Tapescu, Peter J. Madsen, Pedro R. Lowenstein, Maria G. Castro, Stephen J. Bagley, Yi Fan, Steven Brem
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Originally devised for cancer control, mRNA vaccines have risen to the forefront of medicine as effective instruments for control of infectious disease, notably their pivotal role in combating the COVID-19 pandemic. This review focuses on fundamental
Externí odkaz:
https://doaj.org/article/0e9534d7859743ec97b686ecc2e43474
Autor:
S. Böning, F. Schneider, A.-K. Huber, D. Langhoff, H. Lin, A. Kaczorowski, A. Stenzinger, M. Hohenfellner, S. Duensing, A. Duensing
Publikováno v:
Immuno-Oncology and Technology, Vol 23, Iss , Pp 100727- (2024)
Background: Spatial biology is an emerging concept to interrogate tumor heterogeneity. The NanoString GeoMx® Digital Spatial Profiling (DSP) platform has become increasingly available. It combines high-plex analysis of protein or messenger RNA expre
Externí odkaz:
https://doaj.org/article/ed80adec76e24926bc48da86a8414767
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Immunotherapy has proved to be a breakthrough in cancer treatment. So far, a bulk of the approved/late-stage cancer immunotherapy are antibody-based. Although these antibody-based drugs have demonstrated great promise, a majority of them are limited
Externí odkaz:
https://doaj.org/article/ffba05186a044a9e8b91fa4bcefb320a
Autor:
Joaquim Carreras, Naoya Nakamura
Publikováno v:
Hemato, Vol 5, Iss 2, Pp 119-143 (2024)
Background: Artificial intelligence in medicine is a field that is rapidly evolving. Machine learning and deep learning are used to improve disease identification and diagnosis, personalize disease treatment, analyze medical images, evaluate clinical
Externí odkaz:
https://doaj.org/article/acfd57d3848140e8be0c4b638bb84d28
Publikováno v:
Genes and Diseases, Vol 11, Iss 2, Pp 807-818 (2024)
Immune checkpoint inhibitors (ICIs) are monoclonal antibody antagonists, which can block cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed death-1/ligand-1 (PD-1/PD-L1) pathways, and other molecules exploited by tumor cells to evade T cell-mediat
Externí odkaz:
https://doaj.org/article/ffeb053e24d440bfa4a1a3d9d78c654a
Delineating the nexus between gut-intratumoral microbiome and osteo-immune system in bone metastases
Publikováno v:
Bone Reports, Vol 23, Iss , Pp 101809- (2024)
Emerging insights in osteoimmunology have enabled researchers to explore in depth the role of immune modulation in regulating bone health. Bone is one of the common sites of metastasis notably in case of breast cancer, prostate cancer and several oth
Externí odkaz:
https://doaj.org/article/4196d6e425fc44398e21839f9f73dfb7
Autor:
Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny, Laura von Schantz
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTDespite the large number of existing bispecific antibody (bsAb) formats, the generation of novel bsAbs is still associated with development and bioprocessing challenges. Here, we present RUBY, a novel bispecific antibody format that allows ra
Externí odkaz:
https://doaj.org/article/3554ed116f6c45079b118217d1d8fd6f
Autor:
Diana I. Albu, Benjamin J. Wolf, Yan Qin, Xianzhe Wang, Amy Daniel Ulumben, Mei Su, Vivian Li, Eirene Ding, Jose Angel Gonzalo, Jason Kong, Ruturaj Jadhav, Nelly Kuklin, Alberto Visintin, Bing Gong, Thomas J. Schuetz
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTCombinatorial strategies, such as targeting different immune checkpoint receptors, hold promise to increase the breadth and duration of the response to cancer therapy. Here we describe the preclinical evaluation of CTX-8371, a protein constru
Externí odkaz:
https://doaj.org/article/5e1ca35cffdd474daf5caef1c125a47e