Zobrazeno 1 - 10
of 3 215
pro vyhledávání: '"immune-dysfunction"'
Publikováno v:
Zhongguo linchuang yanjiu, Vol 37, Iss 11, Pp 1659-1664 (2024)
Sepsis is a clinically common critical illness with high mortality rate. Acute respiratory distress syndrome (ARDS), an acute inflammatory lung injury disease, is a common complication during the development of sepsis and can lead to a significant in
Externí odkaz:
https://doaj.org/article/25c6cd12887b4d098b7c9a445a17bd85
Autor:
Georg Peschel, Nils Happ, Jan Bornschein, Florian Weis, Stephan Schmid, Martina Mueller, Michael Selgrad
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundPneumocystis jirovecci pneumonia (PCP) is a life threating disease in immunodeficient patients. Liver cirrhosis itself can lead to immunodefiency, however little is known if Pneumocystis jirovecci infection affects the outcome of patients w
Externí odkaz:
https://doaj.org/article/c48a48cee6ee49bc8dc3d3176106deea
Autor:
Tong Liu, Gang Wu, Cathrin L.C. Gudd, Francesca M. Trovato, Thomas Barbera, Yan Liu, Evangelos Triantafyllou, Mark J.W. McPhail, Mark R. Thursz, Wafa Khamri
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105336- (2024)
Summary: Background: Immune dysfunction contributes to a high rate of infection in patients with acute decompensation of cirrhosis. CD52 is a glycoprotein prominently expressed in lymphocytes. Immune regulation by CD52 may be involved in adaptive imm
Externí odkaz:
https://doaj.org/article/ba85926b98244f02a120cb26e57cd74a
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Sepsis is a dysregulated host response to severe infections, and immune dysfunction plays a crucial role in its pathogenesis. Elderly patients, a special population influenced by immunosenescence, are more susceptible to sepsis and have a wo
Externí odkaz:
https://doaj.org/article/12fd8dca58a94d07b2d187fcc0efd079
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-24 (2024)
Abstract Background Molecular subtyping is expected to enable precise treatment. However, reliable subtyping strategies for clinical application remains defective and controversial. Given the significance of tumor immune dysfunction and exclusion (TI
Externí odkaz:
https://doaj.org/article/01fbd10442c34ff18393916bad9b6167
Akademický článek
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Akademický článek
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Autor:
Sulogna Sarkar, Vani S. Prasanna, Pamelika Das, Hiroshi Suzuki, Kazuya Fujihara, Satoru Kodama, Hirohito Sone, Remya Sreedhar, Ravichandiran Velayutham, Kenichi Watanabe, Somasundaram Arumugam
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Metabolic compromise is crucial in aggravating age-associated chronic inflammation, oxidative stress, mitochondrial damage, increased LDL and triglycerides, and elevated blood pressure. Excessive adiposity, hyperglycemia, and insulin resistance due t
Externí odkaz:
https://doaj.org/article/5a2125cba2304e8b9898d23b7ec3b133
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
This mini review summarizes the immunobiology of myelodysplastic syndromes, specifically focusing on the interactions between immune cells, cytokines, and dysplastic cells within the tumor microenvironment in the bone marrow. We elucidate in detail h
Externí odkaz:
https://doaj.org/article/cbac39427a0f47748f7d78a8856e0f0c
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 54, Iss , Pp 101007- (2024)
B7-H4 is a promising immune checkpoint molecule in tumor immunotherapy. Our previous study showed that high B7-H4 expression was strongly correlated with deficiency in tumor infiltrated lymphocytes (TILs) in glioma patients. On this basis, we investi
Externí odkaz:
https://doaj.org/article/df861747a1a14476b2507f872e9f9885