Zobrazeno 1 - 10
of 266
pro vyhledávání: '"immune signatures"'
Autor:
Yang Li, Yuan Chen, Yang Zhang, Yunsheng Fang, Ling Wu, Ying Zhao, Danqiong Wang, Xiaoyuan Qiao
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundHepatocellular carcinoma (HCC) is a common malignancy worldwide, and its development is closely related to abnormalities in iron metabolism. This study aims to systematically analyze changes in iron metabolism in the tumor microenvironment
Externí odkaz:
https://doaj.org/article/95ab332e1ef844e9b562627ac4d7ad00
Autor:
Tamara Cruz, Núria Mendoza, Sandra Casas-Recasens, Guillaume Noell, Fernanda Hernandez-Gonzalez, Alejandro Frino-Garcia, Xavi Alsina-Restoy, María Molina, Mauricio Rojas, Alvar Agustí, Jacobo Sellares, Rosa Faner
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background The role of the immune system in the pathobiology of Idiopathic Pulmonary Fibrosis (IPF) is controversial. Methods To investigate it, we calculated immune signatures with Gene Set Variation Analysis (GSVA) and applied them to the
Externí odkaz:
https://doaj.org/article/ebbbbc48513b4873af46751e4694931e
Autor:
Tieyan Wang, Dan Yu, Juanjuan Wang, Ningning Zhu, Xian-bin Tang, Xiuwen Chen, Xiao-min Su, Yu-gang Huang
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundPOLE is a critical biomarker for endometrial cancer (ECs) prognosis and therapeutic decision. However, the immune infiltration and immunotherapy-related gene expression in the tumor microenvironment (TME) of POLE-mutated ECs remain unresolv
Externí odkaz:
https://doaj.org/article/f8b36a6c908944a9897acc2b7ae54997
Autor:
Qian Li, Minawaer Hujiaaihemaiti, Jie Wang, Md. Nazim Uddin, Ming-Yuan Li, Alidan Aierken, Yun Wu
Publikováno v:
Mathematical Biosciences and Engineering, Vol 20, Iss 2, Pp 4153-4177 (2023)
Background: The deregulated genetic factors are critically associated with idiopathic pulmonary arterial hypertension (IPAH) development and progression. However, the identification of hub-transcription factors (TFs) and miRNA-hub-TFs co-regulatory
Externí odkaz:
https://doaj.org/article/e4f6aa009b8e43c2bc0ae44955fc9c29
Autor:
Niluopaer Tuerxun, Jie Wang, Yu-ting Qin, Fang Zhao, Huan Wang, Jian-hua Qu, Md. Nazim Uddin, Jian-ping Hao
Publikováno v:
Hematology, Vol 27, Iss 1, Pp 506-517 (2022)
The deregulation of microRNAs (miRNAs) and genes in the bone marrow microenvironment have been involved with the pathogenesis of multiple myeloma (MM). However, the exploration of miRNA-mRNA regulatory networks in MM remains lacking. We used GSE12536
Externí odkaz:
https://doaj.org/article/84925285fcce43038e5a5f75a4a286ce
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Yan Gao, Lingling Yuan, Jing Zeng, Fuyan Li, Xiaohui Li, Fan Tan, Xusheng Liu, Huabing Wan, Xueyan Kui, Xiaoyu Liu, Changbin Ke, Zhijun Pei
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Although eukaryotic initiation factor 6 (eIF6) is a novel therapeutic target, data on its importance in the development of esophageal carcinoma (ESCA) remains limited. This study evaluated the correlation between eIF6 expression a
Externí odkaz:
https://doaj.org/article/6c562d7ec2b2414d9b95907c72c0b072
Autor:
Yu Pan, Jianfeng Gao, Jiajing Lin, Yuan Ma, Zelin Hou, Yali Lin, Shi Wen, Minggui Pan, Fengchun Lu, Heguang Huang
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies with poor response to immune checkpoint inhibitors. The mechanism of such poor response is not completely understood.MethodsWe assessed T-cell receptor (TCR) r
Externí odkaz:
https://doaj.org/article/1fee66d3b490463aa01a0334d61eb27e
Autor:
Guoxing Zheng, Yingsi Lu, Zheng Yang, Hong Chen, Qian Liang, Qingqing Zhu, Yan Li, Xing Xiao, Zhuzhen He, Yifan Zhu, Bo Li, Leilei Huang, Nan Dong, Shuang Hu, Yihang Pan, Changhua Zhang, Chengming Zhu
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundAlthough many efforts have been devoted to identify biomarkers to predict the responsiveness of immune checkpoint inhibitors, including expression of programmed death-ligand 1 (PD-L1) and major histocompatibility complex (MHC) I, microsatel
Externí odkaz:
https://doaj.org/article/ae40194667884716a496ff6b0afb7e40
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Sarcomas are highly heterogeneous in molecular, pathologic, and clinical features. However, a classification of sarcomas by integrating different types of pathways remains mostly unexplored. Methods We performed hierarchical clust
Externí odkaz:
https://doaj.org/article/2f2dd24ab6654fd4b2c183477f93ec5c