Zobrazeno 1 - 10
of 826
pro vyhledávání: '"immune senescence"'
Autor:
A.L.S. Cunha, S.F. Perazzio
Publikováno v:
Brazilian Journal of Medical and Biological Research, Vol 57 (2024)
Innate immune system activation is crucial in the inflammatory response, but uncontrolled activation can lead to autoimmune diseases. Cellular exhaustion and senescence are two processes that contribute to innate immune tolerance breakdown. Exhausted
Externí odkaz:
https://doaj.org/article/66d0c0808aee4274844e31b42980402f
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cell senescence is an indication of T cell dysfunction. The ability of senescent T cells to respond to cognate antigens is reduced and they are in the late stage of differentiation and proliferation; therefore, they cannot recognize and eliminate t
Externí odkaz:
https://doaj.org/article/34a0be0754f6421b8b72548a8b97c067
Autor:
Christine M. Dang, C. Mindy Nelson, Daniel J. Feaster, Alexander Kizhner, David W. Forrest, Nobuyo Nakamura, Akshay Iyer, Priya P. Ghanta, Dushyantha T. Jayaweera, Allan E. Rodriguez, Rajendra N. Pahwa, Hansel E. Tookes, Suresh Pallikkuth, Savita G. Pahwa
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPeople with HIV (PWH) are known to have underlying inflammation and immune activation despite virologic control. Substance use including opioid dependence is common in this population and is associated with increased morbidity and reduced
Externí odkaz:
https://doaj.org/article/15ebc3043ace448898e88d710a3bd61f
Autor:
Shanmuga Sundaram Mahalingam, Sangeetha Jayaraman, Adhvika Arunkumar, Holly M. Dudley, Donald D. Anthony, Carey L. Shive, Jeffrey M. Jacobson, Pushpa Pandiyan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019 (COVID-19) that presents with varied clinical manifestations ranging from asymptomatic or mild infections and pneumonia to severe cases associated with cytok
Externí odkaz:
https://doaj.org/article/a75f7b50e5ed437bbec05ec3bbadc701
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Nasopharyngeal carcinoma (NPC) is a kind of epithelial carcinoma that is common in East and Southeast Asia. Distant metastasis after radiotherapy remains the main cause of treatment failure and preradiotherapy immune system functi
Externí odkaz:
https://doaj.org/article/2bd4aa6632844282bd6b4bea2aebfbc7
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 49, Iss 11, Pp 1134-1138 (2022)
Objective To explore the effect of immune senescence on lung cancer metastasis and reveal the mechanism of Fuzheng traditional Chinese medicine Jinfukang in the prevention and treatment of the metastasis. Methods A lung metastasis model of Lewis lung
Externí odkaz:
https://doaj.org/article/d458c875dcc2426abcf88007ae255f89
Akademický článek
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Akademický článek
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Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-13 (2022)
Abstract Inclusion body myositis (IBM) is the most prevalent idiopathic inflammatory myopathy (IIM) affecting older adults. The pathogenic hallmark of IBM is chronic inflammation of skeletal muscle. At present, we do not classify IBM into different s
Externí odkaz:
https://doaj.org/article/049d3b6764cc49f785c93e14dd35b9dd
Autor:
Annette Bellar, Nicole Welch, Jaividhya Dasarathy, Amy Attaway, Ryan Musich, Avinash Kumar, Jinendiran Sekar, Saurabh Mishra, Yana Sandlers, David Streem, Laura E Nagy, Srinivasan Dasarathy
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 5, Pp n/a-n/a (2023)
Abstract Background Patients with acute alcohol‐associated hepatitis (AH) have immune dysfunction. Mitochondrial function is critical for immune cell responses and regulates senescence. Clinical translational studies using complementary bioinformat
Externí odkaz:
https://doaj.org/article/881a67875696428382c69cb550c103a6