Preventing HIV infection without targeting the virus: how reducing HIV target cells at the genital tract is a new approach to HIV prevention

Autor: Julie Lajoie, Lucy Mwangi, Keith R. Fowke

Publikováno v: AIDS Research and Therapy, Vol 14, Iss 1, Pp 1-5 (2017)

Abstract For over three decades, HIV infection has had a tremendous impact on the lives of individuals and public health. Microbicides and vaccines studies have shown that immune activation at the genital tract is a risk factor for HIV infection. Fur

Externí odkaz: https://doaj.org/article/c3b2b33be79e431ab6f88d4248028a65

Genetic Rescue of X-Linked Retinoschisis Mouse (Rs1-/y) Retina Induces Quiescence of the Retinal Microglial Inflammatory State Following AAV8-RS1 Gene Transfer and Identifies Gene Networks Underlying Retinal Recovery

Autor: Matthew Brooks, Camasamudram Vijayasarathy, Paul A. Sieving, Yong Zeng, Robert N. Fariss

Publikováno v: Human gene therapy, vol 32, iss 13-14
Human Gene Therapy

To understand RS1 gene interaction networks in the X-linked retinoschisis (XLRS) mouse retina (Rs1−/y), we analyzed the transcriptome by RNA sequencing before and after in vivo expression of exogenous retinoschisin (RS1) gene delivered by AAV8. RS1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af07345339f210fd84da2dded94c876
https://escholarship.org/uc/item/4117h4z2

Combating HIV/AIDS: biomedical approaches towards prevention

Autor: Mwangi, L.W., Lajoie, J., Oyugi, J.O., Fowke, K.R.

Publikováno v: African Journal of Biomedical Research; Vol. 22 No. 2 (2019); 105-114
African Journal of Biomedical Research; Vol 22, No 2 (2019); 105-114

For over three decades, HIV/AIDS has had a deleterious impact on public health the world over. There is still no cure for the disease although preventive strategies have evolved over the years to reduce its impact. In addition to behavioural change a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b1b7c9d675e43196d688d3159ba94d20
https://www.ajol.info/index.php/ajbr/article/view/190599

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Using safe, affordable and accessible non-steroidal anti-inflammatory drugs to reduce the number of HIV target cells in the blood and at the female genital tract

Autor: Julius Oyugi, Kenzie Birse, Sarah Mutch, Lucy Mwangi, Emmanuel A. Ho, Juliana Cheruiyot, Joshua Kimani, John N. Mungai, Makobu Kimani, Maureen Akolo, Adam Burgener, Geneviève Boily-Larouche, Laura Romas, Julie Lajoie, Keith R. Fowke, Yufei Chen

Publikováno v: Journal of the International AIDS Society

Introduction At its basic level, HIV infection requires a replication‐competent virus and a susceptible target cell. Elevated levels of vaginal inflammation has been associated with the increased risk of HIV infection as it brings highly activated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60ebc983124f7dbab464fcf46933da5
https://doi.org/10.1002/jia2.25150