Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity

Autor: Lin, Jonah, Law, Ryan, Korosec, Chapin S., Zhou, Christine, Koh, Wan Hon, Ghaemi, Mohammad Sajjad, Samaan, Philip, Ooi, Hsu Kiang, Matveev, Vitaliy, Yue, FengYun, Gingras, Anne-Claude, Estacio, Antonio, Buchholz, Megan, Cheatley, Patti Lou, Mohammadi, Avid, Kaul, Rupert, Pavinski, Katerina, Mubareka, Samira, McGeer, Allison J., Leis, Jerome A., Heffernan, Jane M., Ostrowski, Mario

Publikováno v: Journal of virology. 96(13)

Our findings highlight the relative importance of SARS-CoV-2-specific GzmB-producing T cell responses in SARS-CoV-2 control and shared CD4 and CD8 immunodominant epitopes in seasonal coronaviruses or SARS-CoV-1, and they indicate robust persistence o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9288d342584376dff9baf31dafbfc162
https://pubmed.ncbi.nlm.nih.gov/35699447

An agent based modeling approach for the analysis of tuberculosis – immune system dynamics

Autor: Marzio Pennisi, Giuseppe Alessandro, Giuseppe Sgroi, Parasiliti Palumbo, Giulia Russo, Epifanio Fichera, Francesco Pappalardo, Santo Motta

Publikováno v: 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
BIBM

Tuberculosis is one of the world’s deadliest diseases that infects one third of the world’s population, mostly in developing countries. However, tuberculosis is becoming again very dangerous also for developed countries, due to the increased mobi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca079f9dfa01cbcedc081cf3384fccac

Multiscale Modeling of the Early CD8 T-Cell Immune Response in Lymph Nodes: An Integrative Study

Autor: Christophe Arpin, Yann Leverrier, Sotiris A. Prokopiou, Olivier Gandrillon, Fabien Crauste, Julien Mafille, Loic Barbarroux, Jacqueline Marvel, Samuel Bernard

Publikováno v: Computation, Vol 2, Iss 4, Pp 159-181 (2014)
Computation
Computation, MDPI, 2014, 2 (4), pp.159-181. ⟨10.3390/computation2040159⟩
Computation, 2014, 2 (4), pp.159-181. ⟨10.3390/computation2040159⟩
Volume 2
Issue 4
Pages 159-181

International audience; CD8 T-cells are critical in controlling infection by intracellular pathogens. Upon encountering antigen presenting cells, T-cell receptor activation promotes the differentiation of naïve CD8 T-cells into strongly proliferatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88560b56e16b67f381c3945c37a0bf31
http://www.mdpi.com/2079-3197/2/4/159

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