Zobrazeno 1 - 10
of 139
pro vyhledávání: '"immortal DNA"'
Publikováno v:
Stem Cell Investigation
Stem Cell Investigation, 2023, 10, pp.9. ⟨10.21037/sci-2023-009⟩
Stem Cell Investigation, 2023, 10, pp.9. ⟨10.21037/sci-2023-009⟩
International audience; Like all immune cells, macrophages do not act autonomously but in unison with other immune cells, surrounding tissues, and the niche they occupy. Constant exchange of information between cellular and noncellular participants w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c2a0b37317c2bc0b9d2f8cd1b4d66a
https://doi.org/10.21037/sci-2023-009
https://doi.org/10.21037/sci-2023-009
Autor:
Pine, Sharon R., Ryan, Brid M., Varticovski, Lyuba, Robles, Ana I., Harris, Curtis C., Wahl, Geoffrey M.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2010 Feb 01. 107(5), 2195-2200.
Externí odkaz:
https://www.jstor.org/stable/40536557
Autor:
Nicolas C. Rivron, Chatarin Wangsanuwat, Siddharth S. Dey, Alex Chialastri, Javier F. Aldeguer
Publikováno v:
Cell reports methods
Cell Reports: Methods, Vol 1, Iss 4, Pp 100060-(2021)
Cell Reports: Methods, Vol 1, Iss 4, Pp 100060-(2021)
SUMMARY Lineage reconstruction is central to understanding tissue development and maintenance. To overcome the limitations of current techniques that typically reconstruct clonal trees using genetically encoded reporters, we report scPECLR, a probabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907e4038540cdbd1c206a0ad96014e11
https://pubmed.ncbi.nlm.nih.gov/34590075
https://pubmed.ncbi.nlm.nih.gov/34590075
Autor:
Sharon R Pine, Wenyu eLiu
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
During tissue homeostasis, normal stem cells self-renew and repopulate the diverse cell types found within the tissue via a series of carefully controlled symmetric and asymmetric cell divisions. The notion that solid tumors comprise a subset of canc
Externí odkaz:
https://doaj.org/article/bc21742cc81341c5bf90c5a3dc9ecf1d
Autor:
Nathan W. Luedtke, Stella M. K. Glasauer, Anne B. Neef, Stephan C.F. Neuhauss, Therese Triemer
Publikováno v:
Cell chemical biology. 28(11)
Asymmetric inheritance of sister chromatids has long been predicted to be linked to discordant fates of daughter cells and even hypothesized to minimize accumulation of mutations in stem cells. Here, we use (2'S)-2'-deoxy-2'-fluoro-5-ethynyluridine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f64b1049ea122e876fc372e57e2195
https://pubmed.ncbi.nlm.nih.gov/34592171
https://pubmed.ncbi.nlm.nih.gov/34592171
Publikováno v:
Symmetry, Vol 12, Iss 1868, p 1868 (2020)
Symmetry
Volume 12
Issue 11
Symmetry
Volume 12
Issue 11
The loss of genetic fidelity in tissue stem cells is considered a significant cause of human aging and carcinogenesis. Many cellular mechanisms are well accepted for limiting mutations caused by replication errors and DNA damage. However, one mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b201f4c98e69e64939b831dacaa03ba
https://www.mdpi.com/2073-8994/12/11/1868
https://www.mdpi.com/2073-8994/12/11/1868
Publikováno v:
Molecular Cell. 66:306-319
Both embryonic and adult stem cells are endowed with a superior capacity to prevent the accumulation of genetic lesions, repair them, or avoid their propagation to daughter cells, which would be particularly detrimental to the whole organism. Inducib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87a0e42251e330f785139721716adc7
https://doi.org/10.1016/j.molcel.2017.04.006
https://doi.org/10.1016/j.molcel.2017.04.006
Publikováno v:
Mech Dev
Long-label retention has been used by many to prove Cairns’ immortal strand hypothesis and to identify potential stem cells. Here, we describe two strategies using 5-ethynl-2’-deoxyuridine (EdU) to identify and understand the distribution of long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b21e3d34430a7ac1c17a920a6b36cee
https://pubmed.ncbi.nlm.nih.gov/31336167
https://pubmed.ncbi.nlm.nih.gov/31336167
Autor:
Alfons J. M. Debets, Duur K. Aanen
Publikováno v:
Proceedings. Biological sciences, 286(1902)
Proceedings of the Royal Society B: Biological Sciences
Proceedings. Biological sciences 286 (2019) 1902
Proceedings of the Royal Society B: Biological Sciences
Proceedings. Biological sciences 286 (2019) 1902
The mutation rate is a fundamental factor in evolutionary genetics. Recently, mutation rates were found to be strongly reduced at high density in a wide range of unicellular organisms, prokaryotic and eukaryotic. Independently, cell division was foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d8b74bd05ba57ad7b91cfe1cc439a3
https://doi.org/10.1098/rspb.2019.0128
https://doi.org/10.1098/rspb.2019.0128
Autor:
Signe Korbo Christiansen, Vibe H. Oestergaard, Michael Lisby, Rune Troelsgaard Pedersen, Irene Gallina
Publikováno v:
Cell Cycle. 15:176-183
Maintenance of genome integrity is crucial to avoid cancer and other genetic diseases. Thus faced with DNA damage, cells mount a DNA damage response to avoid genome instability. The DNA damage response is partially inhibited during mitosis presumably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d715255816c6760f23c38823883a38
https://doi.org/10.1080/15384101.2015.1128595
https://doi.org/10.1080/15384101.2015.1128595