Zobrazeno 1 - 10
of 142
pro vyhledávání: '"igfr"'
Autor:
Gokhan Gorgisen, Zafer Yaren
Publikováno v:
Folia Neuropathologica, Vol 58, Iss 1, Pp 38-44 (2020)
Glioblastoma multiforme (GBM) is the most common and malignant type of central nervous system tumours in adults. Strict regulation of glucose homeostasis has a significant role in GBM pathogenesis. Insulin receptor substrate 1 (IRS1) protein is the m
Externí odkaz:
https://doaj.org/article/133444c2463140faa1b453ac221ce83c
Autor:
Alexander Gähler, Denis I. Trufa, Mircea T. Chiriac, Patrick Tausche, Katja Hohenberger, Ann-Kathrin Brunst, Manfred Rauh, Carol I. Geppert, Ralf J. Rieker, Susanne Krammer, Anna Leberle, Markus F. Neurath, Horia Sirbu, Arndt Hartmann, Susetta Finotto
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundLung cancer is the second common cancer type in western countries and has a high mortality. During the development and progression of the tumor, the nutrients in its environment play a central role. The tumor cells depend crucially on gluco
Externí odkaz:
https://doaj.org/article/5af820fb33ba445790484f248af9f25f
Autor:
Yann Neuzillet, Elodie Chapeaublanc, Clémentine Krucker, Leanne De Koning, Thierry Lebret, François Radvanyi, Isabelle Bernard-Pierrot
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-12 (2017)
Abstract Background The insulin growth factor (IGF) pathway has been proposed as a potential therapeutic target in bladder cancer. We characterized the expression of components of the IGF pathway — insulin growth factor receptors (INSR, IGF1R, IGF2
Externí odkaz:
https://doaj.org/article/6166f90451174a048a406c55c1d81e6c
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Tremblay, Jean-François
This open access handbook compares fiscal federalism arrangements in eleven federal/ decentralized countries. Each chapter examines an individual country, laying out its constitutional design as relates to fiscal powers and the division of those powe
Externí odkaz:
https://library.oapen.org/handle/20.500.12657/75365
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Ettore D'Argento, Antonella Cannella, Chiara Forcella, Michele Milella, Maurizio Martini, Emilio Bria, Emanuele Vita, Alessio Stefani, Carmine Carbone, Isabella Sperduti, M. Ribelli, Vincenzo Di Noia, P. Damiano, Sara Pilotto, Giampaolo Tortora, Miriam Grazia Ferrara, Geny Piro, Mirna Bilotta
Publikováno v:
Clinical lung cancer. 22(4)
Rapid disease progression of patients with advanced epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) has been recently associated with tumor heterogeneity, which may be mirrored by coexisting concomitant alterations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393d5ab970606e74075e5629699d5cd5
https://pubmed.ncbi.nlm.nih.gov/33558194
https://pubmed.ncbi.nlm.nih.gov/33558194
Publikováno v:
The Journal of Biological Chemistry
Insulin-like growth factor (IGF) is a potent mitogen that activates the IGF receptor (IGFR)/insulin receptor substrate (IRS) axis, thus stimulating growth in normal cells and uncontrolled cell proliferation in cancer. Posttranslational modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9f42ab7ea062e1b118be64301e157c
http://europepmc.org/articles/PMC8191236
http://europepmc.org/articles/PMC8191236
Publikováno v:
eLife, Vol 2 (2013)
Under conditions of stress, such as limited growth factor signaling, translation is inhibited by the action of 4E-BP and PDCD4. These proteins, through inhibition of eIF4E and eIF4A, respectively, impair cap-dependent translation. Under stress condit
Externí odkaz:
https://doaj.org/article/609297efddf443b2bc2c6941f9bb89c4
Autor:
Hai‑Na Zhang, Hong‑Yan Li, Zhong‑Min Liu, Ya‑Juan Sun, Qiu‑Li Xue, Huai‑Qiang He, Guang‑Meng Xu, Li‑Hua Dong
Publikováno v:
Molecular Medicine Reports
Berberine presents therapeutic ability for various central nervous system disorders, including Alzheimer's disease and cerebral ischemia. The present study investigated the role of berberine in nerve regeneration and analyzed the potential mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd5eb43ba2ba6bc244b03bdb64e326c
http://europepmc.org/articles/PMC6236264
http://europepmc.org/articles/PMC6236264