Zobrazeno 1 - 10
of 119
pro vyhledávání: '"ifna"'
Publikováno v:
eLife, Vol 12 (2024)
Previously, we showed that a massively parallel reporter assay, mSTARR-seq, could be used to simultaneously test for both enhancer-like activity and DNA methylation-dependent enhancer activity for millions of loci in a single experiment (Lea et al.,
Externí odkaz:
https://doaj.org/article/9db658a652954aa287f21a59463a74d1
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
PD-1 and PD-L1 are crucial regulators of immunity expressed on the surface of T cells and tumour cells, respectively. Cancer cells frequently use PD-1/PD-L1 to evade immune detection; hence, blocking them exposes tumours to be attacked by activated T
Externí odkaz:
https://doaj.org/article/4ec5851958784f21a6bfc09c2d2cd5d6
Autor:
Manuel Keppler, Simon Straß, Sophia Geiger, Tina Fischer, Nadja Späth, Thilo Weinstein, Anna Schwamborn, Jamil Guezguez, Jan-Hinrich Guse, Stefan Laufer, Michael Burnet
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
TLR Agonists have promising activity in preclinical models of viral infection and cancer. However, clinical use is only in topical application. Systemic uses of TLR-ligands such as Resiquimod, have failed due to adverse effects that limited dose and
Externí odkaz:
https://doaj.org/article/8483e3fbceb94d0594311121d3713c86
Publikováno v:
Архивъ внутренней медицины, Vol 12, Iss 3, Pp 212-220 (2022)
The aim of the investigation was to study the relationship between the content of whole blood in mononuclear leukocytes in pneumonia and in apparently healthy individuals of cytokine signaling suppressor 2 (SOCS2) with the production of cytokines (TN
Externí odkaz:
https://doaj.org/article/d557a517feef499abbce4bb61c8b2b50
Autor:
Kyeongseok Jeon, Yuri Kim, Shin Kwang Kang, Uni Park, Jayoun Kim, Nanhee Park, Jaemoon Koh, Man-Shik Shim, Minsoo Kim, Youn Ju Rhee, Hyeongseok Jeong, Siyoung Lee, Donghyun Park, Jinyoung Lim, Hyunsu Kim, Na-Young Ha, Hye-Yeong Jo, Sang Cheol Kim, Ju-Hee Lee, Jiwon Shon, Hoon Kim, Yoon Kyung Jeon, Youn-Soo Choi, Hye Young Kim, Won-Woo Lee, Murim Choi, Hyun-Young Park, Woong-Yang Park, Yeon-Sook Kim, Nam-Hyuk Cho
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/7b6f3ccf4f0e4a69b0ee54577a3d34e6
Autor:
Kyeongseok Jeon, Yuri Kim, Shin Kwang Kang, Uni Park, Jayoun Kim, Nanhee Park, Jaemoon Koh, Man-Shik Shim, Minsoo Kim, Youn Ju Rhee, Hyeongseok Jeong, Siyoung Lee, Donghyun Park, Jinyoung Lim, Hyunsu Kim, Na-Young Ha, Hye-Yeong Jo, Sang Cheol Kim, Ju-Hee Lee, Jiwon Shon, Hoon Kim, Yoon Kyung Jeon, Youn-Soo Choi, Hye Young Kim, Won-Woo Lee, Murim Choi, Hyun-Young Park, Woong-Yang Park, Yeon-Sook Kim, Nam-Hyuk Cho
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionDespite of massive endeavors to characterize inflammation in COVID-19 patients, the core network of inflammatory mediators responsible for severe pneumonia stillremain remains elusive. MethodsHere, we performed quantitative and kinetic an
Externí odkaz:
https://doaj.org/article/d6b2812c7e2a4869bdb57bf4462da77c
Autor:
E. A. Kukushkina, S. I. Koteleva, M. S. Blyakher, I. M. Fedorova, Z. K. Ramazanova, N. N. Zvereva, E. V. Novosad, A. A. Samkov, M. V. Bazarova
Publikováno v:
Инфекция и иммунитет, Vol 11, Iss 1, Pp 157-164 (2021)
The state of the interferon system in 38 children with acute infectious mononucleosis (IM) caused by the Epstein—Barr virus was analyzed. Interferon status was examined in accordance with F.I. Ershov method based on assessing related biological act
Externí odkaz:
https://doaj.org/article/120f1b3844bb44b48a839c79cae22d26
Autor:
Claudia Schubert, Manuel Allhoff, Stefan Tillmann, Tiago Maié, Ivan G. Costa, Daniel B. Lipka, Mirle Schemionek, Kristina Feldberg, Julian Baumeister, Tim H. Brümmendorf, Nicolas Chatain, Steffen Koschmieder
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract Background Interferon alpha (IFNa) monotherapy is recommended as the standard therapy in polycythemia vera (PV) but not in chronic myeloid leukemia (CML). Here, we investigated the mechanisms of IFNa efficacy in JAK2V617F- vs. BCR-ABL-positi
Externí odkaz:
https://doaj.org/article/f04572cd8a7a47c1b8bb12f8129e168b
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Akademický článek
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