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Akademický článek

Rapid transient and longer-lasting innate cytokine changes associated with adaptive immunity after repeated SARS-CoV-2 BNT162b2 mRNA vaccinations

Autor: Margherita Rosati, Evangelos Terpos, Philip Homan, Cristina Bergamaschi, Sevasti Karaliota, Ioannis Ntanasis-Stathopoulos, Santhi Devasundaram, Jenifer Bear, Robert Burns, Tina Bagratuni, Ioannis P. Trougakos, Meletios A. Dimopoulos, George N. Pavlakis, Barbara K. Felber

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionCytokines and chemokines play an important role in shaping innate and adaptive immunity in response to infection and vaccination. Systems serology identified immunological parameters predictive of beneficial response to the BNT162b2 mRNA

Externí odkaz: https://doaj.org/article/ff1d4f55bab147a9957e93a1589ed53e

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Akademický článek

Active tuberculosis patients have high systemic IgG levels and B-cell fingerprinting, characterized by a reduced capacity to produce IFN-γ or IL-10 as a response to M.tb antigens

Autor: Julio Flores-Gonzalez, Alexia Urbán-Solano, Lucero A. Ramón-Luing, Juan Carlos Cancino-Diaz, Araceli Contreras-Rodriguez, Everardo Curiel-Quesada, Rogelio Hernández-Pando, Leslie Chavez-Galan

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionTuberculosis (TB) is a bacterial infection caused by Mycobacterium tuberculosis (M.tb). B cells are the central mediator of the humoral response; they are responsible for producing antibodies in addition to mediating other functions. The

Externí odkaz: https://doaj.org/article/0d21be34a2704660a66380f615c30120

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Akademický článek

Cytokine gene polymorphisms of TNF, IFN-γ, and IL-12 as potential predictors in the onset of cervical disease in HR HPV-positive women with behavioral risk cofactors

Autor: Tasić-Tomić Dijana, Pravica Vera, Tasić Lidija, Lukač Azra, Šačić Mirza, Ćupić Maja

Publikováno v: Srpski Arhiv za Celokupno Lekarstvo, Vol 150, Iss 9-10, Pp 551-557 (2022)

Introduction/Objective. The aim of this study was to investigate the distribution of genotypes and alleles of proinflammatory cytokines TNF, IFN-γ, and IL-12 and their effect on the development of a cervical illness and also to determine their assoc

Externí odkaz: https://doaj.org/article/e51bd761811c45348b39f5838c4bf00f

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Akademický článek

Transforming growth factor receptor III (Betaglycan) regulates the generation of pathogenic Th17 cells in EAE

Autor: Samuel J. Duesman, Sandra Ortega-Francisco, Roxana Olguin-Alor, Naray A. Acevedo-Dominguez, Christine M. Sestero, Rajeshwari Chellappan, Patrizia De Sarno, Nabiha Yusuf, Adrian Salgado-Lopez, Marisol Segundo-Liberato, Selina Montes de Oca-Lagunas, Chander Raman, Gloria Soldevila

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

The transforming growth factor receptor III (TβRIII) is commonly recognized as a co-receptor that promotes the binding of TGFβ family ligands to type I and type II receptors. Within the immune system, TβRIII regulates T cell development in the thy

Externí odkaz: https://doaj.org/article/272a7123bd184c2dbfd9bcd6002c20c1

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Akademický článek

Cytokine Profiles of Head and Neck Squamous Cell Carcinoma Undergoing Dual Immunotherapy With Cetuximab and Pembrolizumab Identify Interferon Gamma-Induced Protein 10 as Novel Biomarker

Autor: Berszin, Michael, Michaelides, Ioannis, Siemert, Julia, Röhl, Louisa, Wellhausen, Jana, Wald, Theresa, Bohr, Christopher, Künzel, Julian, Gradistanac, Tanja, Dietz, Andreas, Zebralla, Veit, Pirlich, Markus, Wiegand, Susanne, Wichmann, Gunnar

Background: Pembrolizumab and cetuximab are antibodies under investigation in head and neck squamous cell carcinoma (HNSCC) either as single agents or combined with cisplatin and other chemotherapeutic drugs, e.g., 5-fluorouracil and/or docetaxel. Ho

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A84568
https://ul.qucosa.de/api/qucosa%3A84568/attachment/ATT-0/

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Akademický článek

Enhanced Detection of Mycobacterium bovis-Specific T Cells in Experimentally-Infected Cattle

Autor: Paola M. Boggiatto, Carly R. Kanipe, Mitchell V. Palmer

Publikováno v: Frontiers in Veterinary Science, Vol 8 (2021)

Bovine tuberculosis (bTB), caused by infection with Mycobacterium bovis, continues to be a major economic burden associated with production losses and a public health concern due to its zoonotic nature. As with other intracellular pathogens, cell-med

Externí odkaz: https://doaj.org/article/bcff80b825554dc6965fba18fef35a22

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Akademický článek

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Akademický článek

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Akademický článek

Immune Dysregulation in Children with Allergic asthma, a close Relationship between IL-17 but not IL-4 or IFN-g, and Disease Severity

Autor: Meysam Aghajani, Alireza Rafiei, Javad Ghaffari, Reza Valadan, Mostafa Kardan

Publikováno v: Research in Molecular Medicine, Vol 6, Iss 1, Pp 16-29 (2018)

Background : Allergic asthma is a chronic airway inflammatory disease often determined with degrees of inflammation, hypersensitivity, bronchial constriction, and airway changes. Th1, Th2, and Th17 cells are the main cells involved in asthma pathophy

Externí odkaz: https://doaj.org/article/aaa27a3ed60d4806b26689cebf81714a

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