Zobrazeno 1 - 10
of 162
pro vyhledávání: '"ian walsh"'
Autor:
Meiyappan Lakshmanan, Sean Chia, Kuin Tian Pang, Lyn Chiin Sim, Gavin Teo, Shi Ya Mak, Shuwen Chen, Hsueh Lee Lim, Alison P. Lee, Farouq Bin Mahfut, Say Kong Ng, Yuansheng Yang, Annie Soh, Andy Hee-Meng Tan, Andre Choo, Ying Swan Ho, Terry Nguyen-Khuong, Ian Walsh
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2497-2506 (2024)
N-glycosylation can have a profound effect on the quality of mAb therapeutics. In biomanufacturing, one of the ways to influence N-glycosylation patterns is by altering the media used to grow mAb cell expression systems. Here, we explore the potentia
Externí odkaz:
https://doaj.org/article/8c61532e278a4848aa34e06e0575d137
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The increasing demand for biotherapeutics has necessitated the evaluation of their critical quality attributes, one of which is glycosylation, an essential post-translational modification found on many biological molecules. In particular, th
Externí odkaz:
https://doaj.org/article/7d654548ae5148bd87b3dd12dbea191e
Autor:
Ryan Haryadi, Kah Fai Chan, Pao Chun Lin, Yun Lei Tan, Corrine Wan, Wahyu Shahreel, Shi Jie Tay, Terry Nguyen-Khuong, Ian Walsh, Zhiwei Song
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract This report describes the development and characterization of a comprehensive collection of CHO cell glycosylation mutants with significant potential for advancing glycobiology and biotechnology. EPO-Fc and trastuzumab, two model molecules,
Externí odkaz:
https://doaj.org/article/75542e73d23a4b45832f4c42a7c4b5fe
Autor:
Anna Wilson, Claire Carswell, Clare McKeaveney, Karen Atkinson, Stephanie Burton, Clare McVeigh, Lisa Graham-Wisener, Erika Jääskeläinen, William Johnston, Daniel O’Rourke, Joanne Reid, Soham Rej, Ian Walsh, Helen Noble
Publikováno v:
BMC Nephrology, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Individuals with chronic kidney disease experience difficult physical and psychological symptoms, that impact quality of life, and are at increased risk of anxiety and depression. Access to specialist psychological support is limi
Externí odkaz:
https://doaj.org/article/20ccf3d8394c461192a9599376b2fd78
Autor:
Ngan T. B. Nguyen, Hau Wan Leung, Kuin Tian Pang, Shi Jie Tay, Ian Walsh, Andre B. H. Choo, Yuansheng Yang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Monoclonal antibodies (mAbs) eliminate cancer cells via various effector mechanisms including antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), which are influenced by the N-glycan structures o
Externí odkaz:
https://doaj.org/article/ee625f6c9b794d9b9acf5a57efcd681b
Autor:
Hilary I. Palevsky, Sophie Clayton, Heather Benway, Mairead Maheigan, Dariia Atamanchuk, Roman Battisti, Jennifer Batryn, Annie Bourbonnais, Ellen M. Briggs, Filipa Carvalho, Alison P. Chase, Rachel Eveleth, Rob Fatland, Kristen E. Fogaren, Jonathan Peter Fram, Susan E. Hartman, Isabela Le Bras, Cara C. M. Manning, Joseph A. Needoba, Merrie Beth Neely, Hilde Oliver, Andrew C. Reed, Jennie E. Rheuban, Christina Schallenberg, Ian Walsh, Christopher Wingard, Kohen Bauer, Baoshan Chen, Jose Cuevas, Susana Flecha, Micah Horwith, Melissa Melendez, Tyler Menz, Sara Rivero-Calle, Nicholas P. Roden, Tobias Steinhoff, Pablo Nicolás Trucco-Pignata, Michael F. Vardaro, Meg Yoder
Publikováno v:
Frontiers in Marine Science, Vol 11 (2024)
The field of oceanography is transitioning from data-poor to data-rich, thanks in part to increased deployment of in-situ platforms and sensors, such as those that instrument the US-funded Ocean Observatories Initiative (OOI). However, generating sci
Externí odkaz:
https://doaj.org/article/841a29da532546c78fa667fe647dc637
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Stem cells possess the unique ability to differentiate into specialized cell types. These specialized cell types can be used for regenerative medicine purposes such as cell therapy. Myosatellite cells, also known as skeletal muscle stem cell
Externí odkaz:
https://doaj.org/article/36ce7a43c6614b639485cb4f70cfadcf
Autor:
Charlotte Blease, Anna Kharko, Michael Bernstein, Colin Bradley, Muiris Houston, Ian Walsh, Kenneth D Mandl
Publikováno v:
JMIR Medical Education, Vol 9, p e42639 (2023)
BackgroundThe potential for digital health technologies, including machine learning (ML)–enabled tools, to disrupt the medical profession is the subject of ongoing debate within biomedical informatics. ObjectiveWe aimed to describe the opinions of
Externí odkaz:
https://doaj.org/article/f1aad0a1f47647de994e3a0d3f37810a
Autor:
Clare Mc Veigh, Joanne Reid, Claire Carswell, Lindsay Ace, Ian Walsh, Lisa Graham-Wisener, Soham Rej, Angela Potes, Karen Atkinson, Trudi Edginton, Helen Noble
Publikováno v:
BMC Nursing, Vol 20, Iss 1, Pp 1-9 (2021)
Abstract Background Mindfulness can potentially positively impact well-being and resilience in undergraduate nursing students. The psychological well-being of such students undertaking clinical training is paramount to ensure optimal learning, and to
Externí odkaz:
https://doaj.org/article/472cb445e476453688520ce432660ae7
Autor:
Ian Walsh, Matthew Myint, Terry Nguyen-Khuong, Ying Swan Ho, Say Kong Ng, Meiyappan Lakshmanan
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Ensuring consistent high yields and product quality are key challenges in biomanufacturing. Even minor deviations in critical process parameters (CPPs) such as media and feed compositions can significantly affect product critical quality attributes (
Externí odkaz:
https://doaj.org/article/92ace70090b442b389f8aa84b7020cd6