Zobrazeno 1 - 10
of 6 136
pro vyhledávání: '"iPSCs"'
Autor:
Joanne Trinh, Susen Schaake, Carolin Gabbert, Theresa Lüth, Sally A. Cowley, André Fienemann, Kristian K. Ullrich, Christine Klein, Philip Seibler
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Certain structural variants (SVs) including large-scale genetic copy number variants, as well as copy number-neutral inversions and translocations may not all be resolved by chromosome karyotype studies. The identification of gene
Externí odkaz:
https://doaj.org/article/cef0b56f4f56419a8a23798df35cef52
Autor:
Leticia R. Q. Souza, Carolina G. da S. Pedrosa, Teresa Puig-Pijuan, Camila da Silva dos Santos, Gabriela Vitória, João M. A. Delou, Pedro Setti-Perdigão, Luiza M. Higa, Amilcar Tanuri, Stevens Kastrup Rehen, Marília Zaluar P. Guimarães
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The Zika virus (ZIKV) epidemic declared in Brazil between 2015 and 2016 was associated with an increased prevalence of severe congenital malformations, including microcephaly. The distribution of microcephaly cases was not uniform across the
Externí odkaz:
https://doaj.org/article/d8dcaae1fcbd48feb4760630394c60cb
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-12 (2024)
Abstract Background A spinal cord injury (SCI) can result in severe impairment and fatality as well as significant motor and sensory abnormalities. Exosomes produced from IPSCs have demonstrated therapeutic promise for accelerating spinal cord injury
Externí odkaz:
https://doaj.org/article/d08e93e591ed4292b07a290ddc8625ad
Autor:
Anastasiia K. Sudina, Mikhail E. Ivanov, Alexander M. Yurin, Andrey V. Makarov, Timur Kh. Fatkhudinov, Dmitry V. Goldstein, Diana I. Salikhova
Publikováno v:
RUDN Journal of Medicine, Vol 28, Iss 3, Pp 319-330 (2024)
Relevance.The search for new methods of effective therapy for traumatic brain injury is one of the important tasks of modern biomedicine. One promising approach for treating traumatic brain injury is cell therapy. The aim of the work is to study the
Externí odkaz:
https://doaj.org/article/cc90768bf3b04726911aed8d72d7b246
Autor:
Ying-Chieh Wu, Šárka Lehtonen, Kalevi Trontti, Riitta Kauppinen, Pinja Kettunen, Ville Leinonen, Markku Laakso, Johanna Kuusisto, Mikko Hiltunen, Iiris Hovatta, Kristine Freude, Hiramani Dhungana, Jari Koistinaho, Taisia Rolova
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Background Patients with Alzheimer's disease (AD) frequently present with cerebral amyloid angiopathy (CAA), characterized by the accumulation of beta-amyloid (Aβ) within the cerebral blood vessels, leading to cerebrovascular dysfunction. P
Externí odkaz:
https://doaj.org/article/ff2355ab447b4ba585cb169fd9c26369
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Stem-cell-derived therapy is a promising option for tissue regeneration. Human iPSC-derived progenitors of smooth muscle cells (pSMCs) exhibit limited proliferation and differentiation, which minimizes the risk of tumor formation
Externí odkaz:
https://doaj.org/article/ceb20e69da444bb687a2fcf7722516f2
Autor:
E. Sendino Garví, G. J. J. van Slobbe, E. A. Zaal, J. H. F. de Baaij, J. G. Hoenderop, R. Masereeuw, M. J. Janssen, A. M. van Genderen
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Background The KCNJ16 gene has been associated with a novel kidney tubulopathy phenotype, viz. disturbed acid–base homeostasis, hypokalemia and altered renal salt transport. KCNJ16 encodes for Kir5.1, which together with Kir4.1 constitutes
Externí odkaz:
https://doaj.org/article/b7d4d0d2b3144e5f820a6f1db8c9b993
Autor:
Ekaterina Pecksen, Sergey Tkachuk, Cristoph Schröder, Marc Vives Enrich, Anindita Neog, Cory P. Johnson, Niko Lachmann, Hermann Haller, Yulia Kiyan
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Induced pluripotent stem cells (iPSCs)-derived kidney organoids are a promising model for studying disease mechanisms and renal development. Despite several protocols having been developed, further improvements are needed to overc
Externí odkaz:
https://doaj.org/article/d81490d55a0448079acfb38892bbbb75
Autor:
Carole Shum, Sang Yeon Han, Bhooma Thiruvahindrapuram, Zhuozhi Wang, Jill de Rijke, Benjamin Zhang, Maria Sundberg, Cidi Chen, Elizabeth D. Buttermore, Nina Makhortova, Jennifer Howe, Mustafa Sahin, Stephen W. Scherer
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 638-647 (2024)
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas nucleases and human induced pluripotent stem cell (iPSC) technology can reveal deep insight into the genetic and molecular bases of human biology and disease. Undesired editing ou
Externí odkaz:
https://doaj.org/article/fce05ccaaede435b84e6e74474bfe7f5
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Heart failure (HF) is characterized by oxidative stress and mitochondrial dysfunction. This study investigates the therapeutic potential of Necrostatin-1 (Nec-1) delivered through exosomes derived from induced pluripotent stem cel
Externí odkaz:
https://doaj.org/article/2f62009b29954c04b1decd3970525eaf