Zobrazeno 1 - 10
of 52
pro vyhledávání: '"iPSC-derived hepatocytes"'
Autor:
Ruiqi Zhang, Rui Wei, Yangyang Yuan, Na Li, Yang Hu, Kwok‐Hung Chan, Ivan Fan‐Ngai Hung, Hung‐Fat Tse
Publikováno v:
JGH Open, Vol 8, Iss 7, Pp n/a-n/a (2024)
Abstract Background and Aim Currently, SARS‐CoV‐2 is still spreading rapidly and globally. A large proportion of patients with COVID‐19 developed liver injuries. The human‐induced pluripotent stem cell (iPSC)‐derived hepatocytes recapitulat
Externí odkaz:
https://doaj.org/article/6840aec341d44312a40de7a8e58f8ec2
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Rui Wei, Jiayin Yang, Chi-Wa Cheng, Wai-In Ho, Na Li, Yang Hu, Xueyu Hong, Jian Fu, Bo Yang, Yuqing Liu, Lixiang Jiang, Wing-Hon Lai, Ka-Wing Au, Wai-Ling Tsang, Yiu-Lam Tse, Kwong-Man Ng, Miguel A. Esteban, Hung-Fat Tse
Publikováno v:
JHEP Reports, Vol 4, Iss 1, Pp 100389- (2022)
Background & Aims: Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism caused by loss-of-function mutations in ATP7B, which encodes a copper-transporting protein. It is characterized by excessive copper deposition in tissu
Externí odkaz:
https://doaj.org/article/7251fd1424cb470896b40e7153068479
Autor:
Ying Liu, Donna M. Conlon, Xin Bi, Katherine J. Slovik, Jianting Shi, Hailey I. Edelstein, John S. Millar, Ali Javaheri, Marina Cuchel, Evanthia E. Pashos, Jahangir Iqbal, M. Mahmood Hussain, Robert A. Hegele, Wenli Yang, Stephen A. Duncan, Daniel J. Rader, Edward E. Morrisey
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1456-1466 (2017)
Abetalipoproteinemia (ABL) is an inherited disorder of lipoprotein metabolism resulting from mutations in microsomal triglyceride transfer protein (MTTP). In addition to expression in the liver and intestine, MTTP is expressed in cardiomyocytes, and
Externí odkaz:
https://doaj.org/article/d7125650f9fd4644a056f52767d91fcf
Autor:
Xin Bi, Evanthia E. Pashos, Marina Cuchel, Nicholas N. Lyssenko, Mayda Hernandez, Antonino Picataggi, James McParland, Wenli Yang, Ying Liu, Ruilan Yan, Christopher Yu, Stephanie L. DerOhannessian, Michael C. Phillips, Edward E. Morrisey, Stephen A. Duncan, Daniel J. Rader
Publikováno v:
EBioMedicine, Vol 18, Iss C, Pp 139-145 (2017)
Despite the recognized role of the ATP-binding Cassette Transporter A1 (ABCA1) in high-density lipoprotein (HDL) metabolism, our understanding of ABCA1 deficiency in human hepatocytes is limited. To define the functional effects of human hepatocyte A
Externí odkaz:
https://doaj.org/article/946ab8b7ea644fcfaed179b2dcca84c0
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Joseph E. Kaserman, Rhiannon B. Werder, Feiya Wang, Taylor Matte, Michelle I. Higgins, Mark Dodge, Jonathan Lindstrom-Vautrin, Pushpinder Bawa, Anne Hinds, Esther Bullitt, Ignacio S. Caballero, Xu Shi, Robert E. Gerszten, Nicola Brunetti-Pierri, Marc Liesa, Carlos Villacorta-Martin, Anthony N. Hollenberg, Darrell N. Kotton, Andrew A. Wilson
Individuals homozygous for the “Z” mutation in alpha-1 antitrypsin deficiency are known to be at increased risk for liver disease. It has also become clear that some degree of risk is similarly conferred by the heterozygous state. A lack of model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb70821b268df49ff60cd34ad789d9c7
https://hdl.handle.net/11588/907845
https://hdl.handle.net/11588/907845
Autor:
Liu Yuqing, Jiang Lixiang, Hung-Fat Tse, Wing-Hon Lai, Rui Wei, Jiayin Yang, Fu Jian, Yang Hu, Wai-Ling Tsang, Yiu-Lam Tse, Bo Yang, Miguel A. Esteban, Xueyu Hong, Ka-Wing Au, Kwong-Man Ng, Chi-Wa Cheng, Wai-In Ho, Na Li
Publikováno v:
JHEP Reports
JHEP Reports, Vol 4, Iss 1, Pp 100389-(2022)
JHEP Reports, Vol 4, Iss 1, Pp 100389-(2022)
Background & Aims Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism caused by loss-of-function mutations in ATP7B, which encodes a copper-transporting protein. It is characterized by excessive copper deposition in tissue
Publikováno v:
Archives of Toxicology. 93(11):3067-3098
Drug-induced liver injury (DILI) complicates safety assessment for new drugs and poses major threats to both patient health and drug development in the pharmaceutical industry. A number of human liver cell-based in vitro models combined with toxicoge