Výsledky vyhledávání - "iNOS, inducible NO synthase"

Nitric oxide (NO) and nanoparticles – Potential small tools for the war against COVID-19 and other human coronavirus infections

Autor: Amedea B. Seabra, Joana C. Pieretti, Olga Rubilar, Gonzalo Tortella, Richard Weller

Publikováno v: Virus Research
Pieretti, J C, Rubilar, O, Weller, R B, Tortella, G R & Seabra, A B 2020, ' Nitric oxide (NO) and nanoparticles – Potential small tools for the war against COVID-19 and other human coronavirus infections ', Virus Research, vol. 291, pp. 198202 . https://doi.org/10.1016/j.virusres.2020.198202

Graphical abstract
Highlights • Nitric oxide has shown antiviral potential against respiratory viral infections. • Protocols of inhaled nitric oxide against COVID-19 are in current trial. • Current trials might indicate suitable parameters

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Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms

Autor: Andreas Koeberle, Oliver Werz, Onno Kranenburg, Solveigh C. Koeberle, Jamila Laoukili, Anna P. Kipp, André Gollowitzer

Publikováno v: Redox Biology, Vol 28, Iss, Pp-(2020)
Redox Biology

Glutathione peroxidase 2 (GPx2) is one of the five selenoprotein GPxs having a selenocysteine in the active center. GPx2 is strongly expressed in the gastrointestinal epithelium, as is another isoform, GPx1, though with a different localization patte

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http://www.sciencedirect.com/science/article/pii/S2213231719312546

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Mo-MDSCs are pivotal players in colorectal cancer and may be associated with tumor recurrence after surgery

Autor: Izabela Siemińska, Kazimierz Węglarczyk, Marta Walczak, Agata Czerwińska, Radosław Pach, Mateusz Rubinkiewicz, Antoni Szczepanik, Maciej Siedlar, Jarek Baran

Publikováno v: Translational Oncology
Translational Oncology, Vol 17, Iss, Pp 101346-(2022)

Highlights • Colorectal cancer patients present increased level of all MDSCs populations in peripheral blood. • Eosinophilic MDSCs can be distinguished among PMN-MDSCs in the blood of colorectal cancer patients. • In patients with colorectal ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3add3e023240e7ba91e9ad85e8df7ac5
https://doi.org/10.1016/j.tranon.2022.101346

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Can FeNO be a biomarker in the post-COVID-19 patients monitoring?

Autor: Mauro Maniscalco, Pasquale Ambrosino, Remo Poto, Salvatore Fuschillo, Sergio Poto, Maria Gabriella Matera, Mario Cazzola

Publikováno v: Respiratory Medicine

The nature of the inflammatory and fibrotic processes found in patients with post-COVID-19 syndrome makes it possible to speculate that in such patients fractional exhaled nitric oxide (FeNO) may be a useful biomarker. Consequently, we set out to ver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0317efb149650c2aab26934df0932d41
https://doi.org/10.1016/j.rmed.2022.106745

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Consumption of decaffeinated coffee protects against the development of early non-alcoholic steatohepatitis: Role of intestinal barrier function

Autor: Ina Bergheim, Finn Jung, Anika Nier, Cheng Jun Jin, Annette Brandt, Anja Baumann, José C. Fernández-Checa, Vicent Ribas, Carmen García-Ruiz

Publikováno v: Redox Biology
Redox Biology, Vol 21, Iss, Pp-(2019)
Digital.CSIC. Repositorio Institucional del CSIC
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Background Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide lacking universally accepted therapies. Studies suggest that coffee consumption is associated with a reduced risk of NAFLD; however, molecular mec

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https://hdl.handle.net/11353/10.1172206

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Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF) mediates innate immune responses in murine peritoneal mesothelial cells through TLR3 and TLR4 stimulation

Autor: Taehyoun Kim, Eun-Ha Hwang, Sang-Muk Oh, Kyung-Bok Lee, Soo-Jin Yang, Jong-Hwan Park

Publikováno v: Cytokine

Highlights • TRIF is involved in cytokines and chemokines production by poly I:C and LPS in PMCs. • TRIF mediates iNOS expression and NO production by poly I:C or LPS in PMCs. • TRIF is required for IFN-β gene expression in PMCs stimulated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26b83ab6d5355e69f082230ae0a29fa
https://doi.org/10.1016/j.cyto.2015.11.010

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Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice

Autor: Marika Cordaro, Giuseppe Bruschetta, Jose Maria Zubelia, Rosalia Crupi, Daniela Impellizzeri, Rosalba Siracusa, Emanuela Esposito, Virginia Motilva, Salvatore Cuzzocrea, Antonio Montero Alcaide, Elena Talero

Publikováno v: British Journal of Nutrition. 114:853-865

Polyphenols have been described to have a wide range of biological activities, and many reports, published during recent years, have highlighted the beneficial effects of phenolic compounds, illustrating their promising role as therapeutic tools in s

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https://doi.org/10.1017/s0007114515002597

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Akademický článek

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Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis

Autor: Irene Locatelli, Francesco Vizzutti, N. Navari, Emanuele Albano, Alessandra Caligiuri, Erica Novo, Maurizio Parola, Massimo Pinzani, W. Delogu, E. Zamara, Fabio Marra, Salvatore Sutti, S. Galastri, E. Vivoli, A. Provenzano, Stefano Milani

Publikováno v: Clinical Science (London, England : 1979)
Clinical Science
Clinical Science; Vol 123

Expression of CCL2 (CC chemokine ligand 2) (or monocyte chemoattractant protein-1) regulates inflammatory cell infiltration in the liver and adipose tissue, favouring steatosis. However, its role in the pathogenesis of steatohepatitis is still uncert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6301da5ba54f78553e0c47b589df9625
http://europepmc.org/articles/PMC3369401

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Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line

Autor: Noel G. Morgan, Philip Newsholme, Shalinee Dhayal, Deirdre Keane, Rui Curi, Hilton Kenji Takahashi

Publikováno v: Clinical Science (London, England : 1979)

Chronic exposure of pancreatic β-cells to saturated non-esterified fatty acids can lead to inhibition of insulin secretion and apoptosis. Several previous studies have demonstrated that saturated fatty acids such as PA (palmitic acid) are detrimenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea47bd0944a23405234a6696ff9cf4eb
https://doi.org/10.1042/cs20100282

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