Zobrazeno 1 - 10
of 341
pro vyhledávání: '"iNKT cell"'
Autor:
Javier Montaño, Josep Garnica, Jun Yamanouchi, Joel Moro, Patricia Solé, Debajyoti Mondal, Pau Serra, Yang Yang, Pere Santamaria
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Unlike conventional CD4+ T cells, which are phenotypically and functionally plastic, invariant NKT (iNKT) cells generally exist in a terminally differentiated state. Naïve CD4+ T cells can acquire alternative epigenetic states in response to differe
Externí odkaz:
https://doaj.org/article/d950d79cdab34b9f8c4189885955f874
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type I NKT cells, also known as Invariant Natural Killer T (iNKT) cells, are a subpopulation of unconventional, innate-like T (ILT) cells which can proficiently influence downstream immune effector functions. Type I NKT cells express a semi-invariant
Externí odkaz:
https://doaj.org/article/5eb12a9522ff4e8998c9d33f80529360
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Invariant natural killer T (iNKT) cells are a distinct subpopulation of innate-like T lymphocytes. They are characterized by semi-invariant T cell receptors (TCRs) that recognize both self and foreign lipid antigens presented by CD1d, a non-polymorph
Externí odkaz:
https://doaj.org/article/e1fb9e2fd54f4f1b983437cb87eed787
Autor:
Kombo F. N’guessan, Kawthar Machmach, Isabella Swafford, Margaret C. Costanzo, Lindsay Wieczorek, Dohoon Kim, Siriwat Akapirat, Victoria R. Polonis, Punnee Pitisuttithum, Sorachai Nitayaphan, Sanjay Gurunathan, Faruk Sinangil, Suwat Chariyalertsak, Julie A. Ake, Robert J. O’connell, Sandhya Vasan, Dominic Paquin-Proulx
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The RV144 Thai phase III clinical trial’s canarypox–protein HIV vaccine regimen showed modest efficacy in reducing infection. We therefore sought to determine the effects of vaccine administration on innate cell activation and subsequent associat
Externí odkaz:
https://doaj.org/article/b63b37f19fa546188d5104a25d963234
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionCancer is categorized into two types based on the microenvironment: cold and hot tumors. The former is challenging to stimulate through immunity. The immunogenicity of cancer relies on the quality and quantity of cancer antigens, whether
Externí odkaz:
https://doaj.org/article/a2f1b2a265e349ac9661ed7a92fc051a
Autor:
Thomas Hägglöf, Raksha Parthasarathy, Nathaniel Liendo, Elizabeth A. Dudley, Elizabeth A. Leadbetter
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors. Mutations in the scaffolding domain
Externí odkaz:
https://doaj.org/article/6217533d98db42d0ad868a273dc2c06b
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Acute myeloid leukemia (AML) remains an elusive disease to treat, let alone cure, even after highly intensive therapies such as stem cell transplants. Adoptive cell therapeutic strategies based on conventional alpha beta (αβ)T cells are an active a
Externí odkaz:
https://doaj.org/article/37d6be280ac44d4986a65ca4e2b15895
Autor:
Aurélie Robin, Claire Mackowiak, Romain Bost, Fanny Dujardin, Alice Barbarin, Antoine Thierry, Thierry Hauet, Luc Pellerin, Jean-Marc Gombert, Ephrem Salamé, André Herbelin, Louise Barbier
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Over the past thirty years, the complexity of the αβ-T cell compartment has been enriched by the identification of innate-like T cells (ITCs), which are composed mainly of invariant natural killer T (iNKT) cells and mucosal-associated invariant T (
Externí odkaz:
https://doaj.org/article/4a8c202f2f744087ab161fad70102311
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Invariant natural killer T (iNKT) cells are a unique T lymphocyte population expressing semi-invariant T cell receptors (TCRs) that recognise lipid antigens presented by CD1d. iNKT cells exhibit potent anti-tumour activity through direct killing mech
Externí odkaz:
https://doaj.org/article/742393c1a913480293ed915ffaa2b8dc
Autor:
Yan-Ruide Li, Zachary Spencer Dunn, Gustavo Garcia, Camille Carmona, Yang Zhou, Derek Lee, Jiaji Yu, Jie Huang, Jocelyn T. Kim, Vaithilingaraja Arumugaswami, Pin Wang, Lili Yang
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Background New COVID-19 treatments are desperately needed as case numbers continue to rise and emergent strains threaten vaccine efficacy. Cell therapy has revolutionized cancer treatment and holds much promise in combatting infectious disea
Externí odkaz:
https://doaj.org/article/74aabd5ed65c4d0f9920f86e4f4d975d