Zobrazeno 1 - 10
of 199
pro vyhledávání: '"iEDDA"'
Autor:
Eva Schlein, Johanna Rokka, Luke R. Odell, Sara Lopes van den Broek, Matthias M. Herth, Umberto M. Battisti, Stina Syvänen, Dag Sehlin, Jonas Eriksson
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Background The brain is a challenging target for antibody-based positron emission tomography (immunoPET) imaging due to the restricted access of antibody-based ligands through the blood–brain barrier (BBB). To overcome this physiological o
Externí odkaz:
https://doaj.org/article/b44e94073a1c42c6b15c9f32f6ffe379
Autor:
Jeonghaeng Cho, Byungseop Yang, Jae Hun Lee, Hyunwoo Kim, Hyeongseok Kim, Eun Byeol Go, Dong-ho Bak, Su Jin Park, Inchan Kwon, Jong-il Choi, Kyunghee Lee
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-11 (2023)
Abstract Background Exogenously providing engineered Uox with enhanced half-life is one of the important urate-lowering treatments for gout. The potential of PAT101, a recombinant human albumin (rHA)-conjugated variant, was evaluated and compared as
Externí odkaz:
https://doaj.org/article/ac493dc4a51e4b37abab1ac829f0460f
Autor:
Sebastian Schötz, Adele K. Griepe, Björn B. Goerisch, Sally Kortam, Yael Shammai Vainer, Mathias Dimde, Hanna Koeppe, Stefanie Wedepohl, Elisa Quaas, Katharina Achazi, Avi Schroeder, Rainer Haag
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1618 (2023)
Rare gastrointestinal stromal tumors (GISTs) are caused by mutations in the KIT and PDGFRA genes. Avapritinib (BLU-285) is a targeted selective inhibitor for mutated KIT and PDGFRA receptors that can be used to treat these tumors. However, there are
Externí odkaz:
https://doaj.org/article/8a1383d23f0b4eabbd602b9ab5892fd4
Akademický článek
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Akademický článek
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Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 15, Iss 6, Pp 752-758 (2020)
The absorption of peptides and proteins delivered orally is minimum because of the intestine epithelial barrier. There are few known active transport mechanisms for macromolecules including the neonatal Fc Receptor (FcRn) for the absorption and secre
Externí odkaz:
https://doaj.org/article/d10192d8f32b4c9bb78ed34138c5b4b9
Autor:
Éva Bokor, Attila Ferenczi, Mahir Hashimov, Éva Juhász-Tóth, Zsófia Götz, Alshimaa Ibrahim Zaki, László Somsák
Publikováno v:
Molecules, Vol 27, Iss 22, p 7801 (2022)
C-glycopyranosyl derivatives of six-membered heterocycles are scarcely represented in the chemical literature and the title 3-glycopyranosyl-1,2,4-triazines are completely unknown. In this paper, the first synthesis of this compound class is accompli
Externí odkaz:
https://doaj.org/article/b01cddca7157495cb2be14b7d0881ebc
Autor:
Soo-Bin Joo, Muhammad Gulfam, Sung-Han Jo, Yi-Jun Jo, Trung Thang Vu, Sang-Hyug Park, Yeong-Soon Gal, Kwon Taek Lim
Publikováno v:
Materials, Vol 15, Iss 20, p 7128 (2022)
In this work, we engineered highly biocompatible and fast absorbent injectable hydrogels derived from norbornene (Nb)-functionalized hyaluronic acid (HA-Nb) and a water-soluble cross-linker possessing tetrazine (Tz) functional groups on both ends of
Externí odkaz:
https://doaj.org/article/323af7c5f65d416981cdfe492b45a29c
Autor:
Alice D'Onofrio, Francisco Silva, Lurdes Gano, Urszula Karczmarczyk, Renata Mikołajczak, Piotr Garnuszek, António Paulo
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Pre-targeting approaches based on the inverse-electron-demand Diels-Alder (iEDDA) reaction between strained trans-cyclooctenes (TCO) and electron-deficient tetrazines (Tz) have emerged in recent years as valid alternatives to classic targeted strateg
Externí odkaz:
https://doaj.org/article/95098ce148764a879ccdc6ecda980801
Autor:
Patricia E. Edem, Jean-Philippe Sinnes, Stefanie Pektor, Nicole Bausbacher, Raffaella Rossin, Abdolreza Yazdani, Matthias Miederer, Andreas Kjær, John F. Valliant, Marc S. Robillard, Frank Rösch, Matthias M. Herth
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-8 (2019)
Abstract Background Pretargeted imaging allows the use of short-lived radionuclides when imaging the accumulation of slow clearing targeting agents such as antibodies. The biotin-(strept)avidin and the bispecific antibody-hapten interactions have bee
Externí odkaz:
https://doaj.org/article/3c3a2b2c7f3b4c0690ccc0893c5a719d