Výsledky vyhledávání - "i.v., intravenous"

Synthesis, characterization & evaluation of venom neutralization potential of silver nanoparticles mediated Alstonia scholaris Linn bark extract

Autor: Sumana Sarkhel, Koushik Mana, Poulami Parua, Upasana Chatterjee, Kanchan Saha, Rituparna Ghosh

Publikováno v: Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 888-895 (2021)

Graphical abstract
Highlights • The venom neutralization potential of silver nanoparticle(AgNP-AS) mediated bark extract of Alstonia scholaris Linn R.Br was investigated in the study. • AgNP-AS was synthesized optimally with AgNO3 (2 mM); ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fcaf32af7fa340908fb4b19dc6b2915
http://europepmc.org/articles/PMC8091482

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Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma

Autor: Wenfu Tan, Huaqian Ding, Xiaohua Liu, Chunyong Ding, Juan Wang, Yalei Li, Ao Zhang, Yu Zhang, Hongchun Liu, Wenjing Huang

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 488-504 (2021)
Acta Pharmaceutica Sinica. B

Medulloblastoma (MB) is a common yet highly heterogeneous childhood malignant brain tumor, however, clinically effective molecular targeted therapy is lacking. Modulation of hedgehog (HH) signaling by epigenetically targeting the transcriptional fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301cde2b3eb755a22e93dd5c8eb925b1
https://doi.org/10.1016/j.apsb.2020.07.007

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Neurological complications in COVID-19 – a diagnostic challenge

Autor: Sorina Frunze, Vitalie Vacaras, Adrian Mihai Cordos

Publikováno v: Journal of Medicine and Life

With the exponential growth of COVID-19 cases, the neurological complications reported during or after the infection became more common. There is limited knowledge regarding the pathophysiological mechanisms that are responsible for these complicatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748f2afbd99e4fd6173f53f6560c4fb8
http://europepmc.org/articles/PMC8169143

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Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

Autor: Ping Zhang, Dingyuan Ma, Li-Ying Peng, Ning-Yuan Sun, Jun Chen, Xiao-Wei Zhang, Weiwei Tang, Lin An

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1397-1413 (2020)

Pyroptosis is a form of programmed cell death, and recently described as a new molecular mechanism of chemotherapy drugs in the treatment of tumors. Miltirone, a derivative of phenanthrene-quinone isolated from the root of Salvia miltiorrhiza Bunge,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750fb5bad337ad6389f2c3000e4927a2
http://europepmc.org/articles/PMC7488361

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Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy

Autor: Zhuowei Liu, Yuxi Wang, Chengjian Zhao, Yang Zhang, Manyu Zhao, Jinliang Yang, Yuqin Yao, Peng Li, Chen Zhengxia, Xiaoxin Chen, Chaofeng Long

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1453-1475 (2020)

Angiokinases, such as vascular endothelial-, fibroblast- and platelet-derived growth factor receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti-angiogenesis therapy using multi-angiokinase inhibitor has achieved great

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6380c470a4be26e380966eab21f579
http://europepmc.org/articles/PMC7488503

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A phase II study of human allogeneic liver-derived progenitor cell therapy for acute-on-chronic liver failure and acute decompensation

Autor: Sébastien Michel, Mustapha Najimi, Yelena Vainilovich, Virginie Barthel, Luc L. Lasser, Victor Vargas, Desislava Lyubomirova, Agustín Albillos, Etienne Sokal, Noelia Gordillo, Nathalie Clerget-Chossat, Frederik Nevens, Pierre-François Laterre, Lyudmil E. Haralampiev, Thierry Gustot, Ivaylo Stoykov

Publikováno v: JHEP Reports
JHEP Reports, 3 (4
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientia
JHEP Reports, Vol 3, Iss 4, Pp 100291-(2021)
JHEP Reports, Vol. 3, no. 4, p. 100291 [1-10] (2021)

Background & Aims: Human allogeneic liver-derived progenitor cells (HALPC, HepaStem®; Promethera Biosciences, Mont-Saint-Guibert, Belgium) are an advanced therapy medicinal product that could potentially alleviate systemic inflammation and ameliorat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af21f831201daccbe657298e10bc15d2
https://lirias.kuleuven.be/handle/123456789/677657

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Immunotherapies in chronic adhesive arachnoiditis: A case series and literature review

Autor: Jana Hackert, Louisa Maßmann, Ulrich Sure, Michael Forsting, Christoph Kleinschnitz, Refik Pul, Tim Hagenacker

Publikováno v: eNeurologicalSci
eNeurologicalSci, Vol 24, Iss, Pp 100350-(2021)

Chronic spinal adhesive arachnoiditis (CSAA) is a rare condition with limited therapeutic options. Surgical treatment proves effective in approximately 60% of cases. Conservative treatment options have not been extensively investigated. Here, we repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::85d37139ddbf9ddcf4e3adcee11f1afc
https://duepublico2.uni-due.de/receive/duepublico_mods_00074715

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Does the proteasome inhibitor bortezomib sensitize to DNA- damaging therapy in gastroenteropancreatic neuroendocrine neoplasms? - A preclinical assessment in vitro and in vivo

Autor: Anja A. Kühl, Monique R. Bernsen, Winfried Brenner, M. Welzel, Richard P. Baum, Samantha Exner, Eva J. Koziolek, Jakob Albrecht, Dagmar Sedding, Patricia Grabowski, Christian Fischer, Fränze Schmidt, Teresa Hartung, Joost C. Haeck, Franziska Briest, Carsten Grötzinger

Publikováno v: Neoplasia (New York, N.Y.)
BASE-Bielefeld Academic Search Engine
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 80-98 (2021)
Neoplasia (United States), 23(1), 80-98

Background: Well-differentiated gastroenteropancreatic neuroendocrine neoplasms are rare tumors with a slow proliferation. They are virtually resistant to many DNA-damaging therapeutic approaches, such as chemo- and external beam therapy, which might

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b0fcaaba5da9ca61e63d327232b0b4
http://www.scopus.com/inward/record.url?scp=85096683387&partnerID=8YFLogxK

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In vivo biodistribution study of TAT-L-Sco2 fusion protein, developed as protein therapeutic for mitochondrial disorders attributed to SCO2 mutations

Autor: Lefkothea C. Papadopoulou, Aikaterini C. Tsika, Georgios A. Spyroulias, Dionysia Papagiannopoulou, Georgios C Kaiafas, Parthenopi C. Chalkidou, Αndroulla N. Miliotou, Asterios S. Tsiftsoglou, Anastasia Tsingotjidou

Publikováno v: Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, Vol 25, Iss, Pp 100683-(2020)

The rapid progress achieved in the development of many biopharmaceuticals had a tremendous impact on the therapy of many metabolic/genetic disorders. This type of fruitful approach, called protein replacement therapy (PRT), aimed to either replace th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb8d0e63c043d0f9b8b0c9877378b60
http://europepmc.org/articles/PMC7726716

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Emerging peptide antibiotics with therapeutic potential

Autor: Gregory Upert, Philipp Ermert, Anatol Luther, Daniel Obrecht

Publikováno v: Medicine in Drug Discovery
Medicine in Drug Discovery, Vol 9, Iss, Pp 100078-(2021)

This review covers some of the recent progress in the field of peptide antibiotics with a focus on compounds with novel or established mode of action and with demonstrated efficacy in animal infection models. Novel drug discovery approaches, linear a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8aaa4f85cc11aaca8bc7a435085ae18
https://pubmed.ncbi.nlm.nih.gov/33398258

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