Dual Antigen T Cell Engagers Targeting CA9 as an Effective Immunotherapeutic Modality for Targeting CA9 in Solid Tumors

Autor: Nazanin Tatari, Xiaoyu Zhang, Shawn C. Chafe, Dillon McKenna, Keith A. Lawson, Minomi Subapanditha, Muhammad Vaseem Shaikh, Mathieu Seyfrid, Neil Savage, Chitra Venugopal, Jason Moffat, Sheila K. Singh

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Glioblastomas (GBM), the most common malignant primary adult brain tumors, are uniformly lethal and are in need of improved therapeutic modalities. GBM contain extensive regions of hypoxia and are enriched in therapy resistant brain tumor-initiating

Externí odkaz: https://doaj.org/article/0954f30be233489fa8bd62d8a5099f88

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CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells

Autor: David Lindgren, Elisa Stellaria Grassi, Vasiliki Pantazopoulou, Elin J. Pietras, Tracy J. Berg, Alexander Pietras, Elinn Johansson, Bei Tong, Håkan Axelson

Publikováno v: Johansson, E, Grassi, E S, Pantazopoulou, V, Tong, B, Lindgren, D, Berg, T J, Pietras, E J, Axelson, H & Pietras, A 2017, ' CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells ', Cell Reports, vol. 20, no. 7, pp. 1641-1653 . https://doi.org/10.1016/j.celrep.2017.07.049
Cell Reports, Vol 20, Iss 7, Pp 1641-1653 (2017)

Hypoxia-inducible factors enhance glioma stemness, and glioma stem cells have an amplified hypoxic response despite residing within a perivascular niche. Still, little is known about differential HIF regulation in stem versus bulk glioma cells. We sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ef1da86a4e6e1a039eb500658198ae
https://curis.ku.dk/portal/da/publications/cd44-interacts-with-hif2-to-modulate-the-hypoxic-phenotype-of-perinecrotic-and-perivascular-glioma-cells(0b86f8d5-eacd-418d-81a5-b4527cad5c7b).html

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