Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells

Autor: Hong-Mou Shih, Szu-Yu Pan, Chih-Jen Wu, Yu-Hsiang Chou, Chun-Yuan Chen, Fan-Chi Chang, Yi-Ting Chen, Wen-Chih Chiang, Hsing-Chen Tsai, Yung-Ming Chen, Shuei-Liong Lin

Publikováno v: Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-17 (2021)

Abstract Background Renal erythropoietin (EPO)-producing (REP) cells produce EPO through hypoxia-inducible factor (HIF) 2α-activated gene transcription. Insufficient EPO production leads to anemia in patients with chronic kidney disease. Although re

Externí odkaz: https://doaj.org/article/4cecab6670294871beec1077d0bd73b3

Vertical sleeve gastrectomy increases duodenal Lactobacillus spp. richness associated with the activation of intestinal HIF2α signaling and metabolic benefits

Autor: Yikai Shao, Simon S. Evers, Jae Hoon Shin, Sadeesh K. Ramakrishnan, Nadejda Bozadjieva-Kramer, Qiyuan Yao, Yatrik M. Shah, Darleen A. Sandoval, Randy J. Seeley

Publikováno v: Molecular Metabolism, Vol 57, Iss , Pp 101432- (2022)

Objective: Vertical Sleeve Gastrectomy (VSG) is one of the most efficacious treatments for obesity and its comorbidities. Although a range of evidence suggests that alterations of the microbiota in the distal gut following VSG are pivotal to these me

Externí odkaz: https://doaj.org/article/831fd8d516454b6b8a5e46bb1c32d9d3

FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter

Autor: Jun Zhu, Xiangning Jiang, Farid F. Chehab

Publikováno v: Journal of Lipid Research, Vol 55, Iss 3, Pp 431-442 (2014)

The late steps of cholesterol biosynthesis are oxygen demanding, requiring eleven oxygen molecules per synthesized cholesterol molecule. A key enzymatic reaction, which occurs at the top of the Bloch and Kandutsch-Russell pathways, is the demethylati

Externí odkaz: https://doaj.org/article/c6aaf474625e418e82244c0e2d9299fd

Serum and Tissue HIF-2 Alpha Expression in CIN, N-Acetyl Cysteine, and Sildenafil-Treated Rat Models: An Experimental Study

Autor: Ismail Altintop, Mehmet Tatli, Cigdem Karakukcu, Zeynep Soyer Sarica, Arzu Hanım Yay, Esra Balcioglu, Ahmet Ozturk

Publikováno v: Medicina, Vol 54, Iss 4, p 54 (2018)

Background and Objectives: Contrast-induced nephropathy (CIN), is acute renal damage due to contrast agents. This study is conducted to evaluate serum and renal heterodimeric nuclear transcription factor (HIF)-2 alpha levels and its tissue expression

Externí odkaz: https://doaj.org/article/a3164796c3524c44b5f14533967bdcf0

Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm

Autor: Yatrik M. Shah, Manuj Tandon, Marina Pasca di Magliano, Christopher J. Halbrook, Min-Jung Park, Jiaqi Shi, Esther Kim, Sadeesh K. Ramakrishnan, Farzad Esni, Heather K. Schofield, M. Bishr Omary

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 2, Pp 169-185.e2 (2018)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 5, iss 2

Background & Aims Tissue hypoxia controls cell differentiation in the embryonic pancreas, and promotes tumor growth in pancreatic cancer. The cellular response to hypoxia is controlled by the hypoxia-inducible factor (HIF) proteins, including HIF2α.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05307ed0730f2a9232c559e082e6e6b7
http://www.sciencedirect.com/science/article/pii/S2352345X17301558