Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy

Autor: So‐Yeon Kim, Nam Gu Yoon, Jin Young Im, Ji Hye Lee, Juhee Kim, Yujin Jeon, Young Jae Choi, Jong‐Hwa Lee, Akiyoshi Uemura, Dong Ho Park, Byoung Heon Kang

Publikováno v: Advanced Science, Vol 11, Iss 2, Pp n/a-n/a (2024)

Abstract Activation of hypoxia‐inducible factor 1α (HIF1α) contributes to blood‐retinal barrier (BRB) breakdown and pathological neovascularization responsible for vision loss in ischemic retinal diseases. During disease progression, mitochondr

Externí odkaz: https://doaj.org/article/40cb9b7d42a6412d9f265e3c8c37eec5

TGF-β protects osteosarcoma cells from chemotherapeutic cytotoxicity in a SDH/HIF1α dependent manner

Autor: Feifan Xiang, Yangbo Xu, Yong Deng, Yafei Li, Xiaofan Chen, Daiqing Wei, Zhong Li

Publikováno v: BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
BMC Cancer

Background In the widespread adoption of chemotherapy, drug resistance has been the major obstacle to tumor elimination in cancer patients. Our aim was to explore the role of TGF-β in osteosarcoma-associated chemoresistance. Methods We performed a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63520c6b7aa5f071bd7808f7ee9cbe13
https://doi.org/10.1186/s12885-021-08954-7

Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy.

Autor: Kim SY; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Yoon NG; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Im JY; SmartinBio Inc., Cheongju, 28160, Republic of Korea., Lee JH; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Kim J; Department of Ophthalmology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea.; Cell & Matrix Research Institute, Kyungpook National University, Daegu, 41944, Republic of Korea., Jeon Y; Department of Ophthalmology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea.; Cell & Matrix Research Institute, Kyungpook National University, Daegu, 41944, Republic of Korea., Choi YJ; Bioanalysis and Pharmacokinetics Research Group, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea., Lee JH; Bioanalysis and Pharmacokinetics Research Group, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea.; Department of Human and Environment Toxicology, University of Science & Technology, Daejeon, 34113, Republic of Korea., Uemura A; Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan., Park DH; Department of Ophthalmology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea.; Cell & Matrix Research Institute, Kyungpook National University, Daegu, 41944, Republic of Korea., Kang BH; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.; SmartinBio Inc., Cheongju, 28160, Republic of Korea.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Jan; Vol. 11 (2), pp. e2302776. Date of Electronic Publication: 2023 Nov 20.

TGF-β protects osteosarcoma cells from chemotherapeutic cytotoxicity in a SDH/HIF1α dependent manner.

Autor: Xu Y; Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.; Sichuan Provincial Laboratory of Orthopaedic Engineering, Luzhou, 646000, Sichuan, China., Li Y; Department of Oncology, Luzhou People's Hospital, Luzhou, 646000, Sichuan, China., Chen X; Department of Pediatrics, Southwest Medical University, Luzhou, 646000, Sichuan, China., Xiang F; Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.; Sichuan Provincial Laboratory of Orthopaedic Engineering, Luzhou, 646000, Sichuan, China., Deng Y; Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.; Sichuan Provincial Laboratory of Orthopaedic Engineering, Luzhou, 646000, Sichuan, China., Li Z; Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.; Sichuan Provincial Laboratory of Orthopaedic Engineering, Luzhou, 646000, Sichuan, China., Wei D; Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China. wdq@swmu.edu.cn.; Sichuan Provincial Laboratory of Orthopaedic Engineering, Luzhou, 646000, Sichuan, China. wdq@swmu.edu.cn.

Publikováno v: BMC cancer [BMC Cancer] 2021 Nov 11; Vol. 21 (1), pp. 1200. Date of Electronic Publication: 2021 Nov 11.

HOTAIRM1 lncRNA is downregulated in clear cell renal cell carcinoma and inhibits the hypoxia pathway.

Autor: Hamilton MJ; Department of Biochemistry, University of California, Riverside, CA, USA., Young M; Department of Biochemistry, University of California, Riverside, CA, USA., Jang K; Department of Biochemistry, University of California, Riverside, CA, USA., Sauer S; Department of Biochemistry, University of California, Riverside, CA, USA., Neang VE; Department of Biochemistry, University of California, Riverside, CA, USA., King AT; Department of Biochemistry, University of California, Riverside, CA, USA., Girke T; Department of Botany and Plant Sciences, University of California, Riverside, CA, USA., Martinez E; Department of Biochemistry, University of California, Riverside, CA, USA. Electronic address: ernest.martinez@ucr.edu.

Publikováno v: Cancer letters [Cancer Lett] 2020 Mar 01; Vol. 472, pp. 50-58. Date of Electronic Publication: 2019 Dec 17.