HCN1 hyperpolarization-activated cyclic nucleotide-gated channels enhance evoked GABA release from parvalbumin-positive interneurons.

Autor: Buss EW; Departments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027., Lofaro OM; Departments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027., Barnett A; Departments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027., Leroy F; Departments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027., Santoro B; Departments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027., Siegelbaum SA; Departments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027., Bock T; Departments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027.; Department of Systems Neurophysiology, Institute for Zoology, Rheinisch-Westfälische Technische Hochschule Aachen University, Aachen 52074, Germany.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct 15; Vol. 121 (42), pp. e2319246121. Date of Electronic Publication: 2024 Oct 08.

Achieving 5 % $^{13}$C nuclear spin hyperpolarization in high-purity diamond at room temperature and low field

Autor: Kavtanyuk, Vladimir V., Lee, Changjae, Jeong, Keunhong, Shim, Jeong Hyun

Optically polarizable nitrogen-vacancy (NV) center in diamond enables the hyperpolarization of $^{13}$C nuclear spins at low magnetic field and room temperature. However, achieving a high level of polarization comparable to conventional dynamic nucle

Externí odkaz: http://arxiv.org/abs/2409.19489

Structural basis for hyperpolarization-dependent opening of human HCN1 channel.

Autor: Burtscher V; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, Saint Louis, MO, USA., Mount J; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, Saint Louis, MO, USA.; Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Huang J; Department of Chemistry, University of Massachusetts, Amherst, MA, USA., Cowgill J; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, Saint Louis, MO, USA.; Department of Applied Physics, KTH Royal Institute of Technology, Stockholm, Sweden., Chang Y; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, Saint Louis, MO, USA., Bickel K; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, Saint Louis, MO, USA., Chen J; Department of Chemistry, University of Massachusetts, Amherst, MA, USA., Yuan P; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, Saint Louis, MO, USA. peng.yuan@mssm.edu.; Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA. peng.yuan@mssm.edu.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. peng.yuan@mssm.edu.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. peng.yuan@mssm.edu., Chanda B; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA. bchanda@wustl.edu.; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, Saint Louis, MO, USA. bchanda@wustl.edu.; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, MO, USA. bchanda@wustl.edu.; Department of Neuroscience, Washington University School of Medicine, Saint Louis, MO, USA. bchanda@wustl.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jun 18; Vol. 15 (1), pp. 5216. Date of Electronic Publication: 2024 Jun 18.

Rapid in situ carbon-13 hyperpolarization and imaging of acetate and pyruvate esters without external polarizer.

Autor: Mohiuddin, Obaid¹ (AUTHOR), de Maissin, Henri^1,2 (AUTHOR), Pravdivtsev, Andrey N.³ (AUTHOR), Brahms, Arne⁴ (AUTHOR), Herzog, Marvin^1,2 (AUTHOR), Schröder, Leif⁵ (AUTHOR), Chekmenev, Eduard Y.⁶ (AUTHOR), Herges, Rainer⁴ (AUTHOR), Hövener, Jan-Bernd³ (AUTHOR), Zaitsev, Maxim¹ (AUTHOR), von Elverfeldt, Dominik¹ (AUTHOR), Schmidt, Andreas B.^1,2,6 (AUTHOR) andreas.schmidt@uniklinik-freiburg.de

Publikováno v: Communications Chemistry. 10/23/2024, Vol. 7 Issue 1, p1-9. 9p.

Investigation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in vitro inflammation model at molecular level.

Autor: Civil Ürkmez Y; Department of Biochemistry, Samsun Training and Research Hospital, University of Health Sciences, Samsun, Turkey. yesimcivil@gmail.com., Avcı B; Department of Biochemistry, School of Medicine, Ondokuz Mayıs University, Samsun, Turkey., Günaydın C; Department of Pharmacology, School of Medicine, Samsun University, Samsun, Turkey., Çelik ZB; Department of Medical Biology, School of Medicine, Samsun University, Samsun, Turkey., Ürkmez SS; Department of Biochemistry, School of Medicine, Ondokuz Mayıs University, Samsun, Turkey.

Publikováno v: Molecular and cellular biochemistry [Mol Cell Biochem] 2024 May; Vol. 479 (5), pp. 1223-1229. Date of Electronic Publication: 2023 Jul 11.