Zobrazeno 1 - 10
of 4 048
pro vyhledávání: '"hypercholesterolaemia"'
Autor:
Joel C Marrs, Sarah L Anderson
Publikováno v:
Drugs in Context, Vol 13, Pp 1-9 (2024)
Inclisiran is a synthetic small interfering RNA (siRNA) that inhibits the production of proprotein convertase subtilisin/ kexin 9 (PCSK9) in hepatocytes by silencing the translation of PCSK9 mRNA. The result of this mechanism is a decrease in PCSK9 s
Externí odkaz:
https://doaj.org/article/40579483425a44878588ab424eb2dc6c
Autor:
Xuan Lyu, Xuanxuan Ren, Weiqing Zhang, Hanqin Zhu, Yu Wang, Jiarou Qiu, Fangying Wu, Sisi Xu, Zhaokai Jin, Minchun Yang
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Objective The weight-adjusted-waist index (WWI) is a novel obesity measurement indicator, and this study aims to determine the relationship between WWI and Familial hypercholesterolemia (FH). Methods Using data from the National Health and N
Externí odkaz:
https://doaj.org/article/127e5a9f02e2428399429235a9d36c74
Autor:
Maximilian A. Muck, Marcus Fischer, Michael Hamerle, Christina Strack, Maxime Holzhaeuer, Dennis Pfeffer, Ute Hubauer, Lars S. Maier, Andrea Baessler
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Background Lowering LDL-cholesterol is a fundamental goal for both primary and secondary prevention of atherosclerotic cardiovascular diseases. Our study aims to analyse potential sex disparities regarding the tolerability and effectiveness
Externí odkaz:
https://doaj.org/article/cad4f53d0fa54dfa85097242039c5343
Autor:
Sudarshan Ramachandran, Amro Maarouf, Karen Mitchell, Tony Avades, Peter Smith, Lee Boulton, Jennifer Kelly, Nitasha Vekaria, Elizabeth Hughes
Publikováno v:
Drugs in Context, Vol 13, Pp 1-11 (2024)
Background: Bempedoic acid, an adenosine triphosphate citrate lyase inhibitor, was introduced to UK practice via a pre-reimbursement access scheme for adults with primary hypercholesterolaemia or mixed dyslipidaemia who are at high risk of cardiovasc
Externí odkaz:
https://doaj.org/article/9f6774c74e7c4137841acfb2c7b85d94
Autor:
Sami G. Almalki, Mohammed Alsaweed, Hind Muteb Albadrani, Yaser E. Alqurashi, Mohammed A. Bazuhair, Hamzah H. Ahmed, Parvej Ahmad, Abdulaziz Alfahed, Ayoub Al Othaim, Danish Iqbal
Publikováno v:
Journal of Taibah University for Science, Vol 18, Iss 1 (2024)
Currently, statins, the β-hydroxy-β-methyl-glutaryl-CoA reductase (HMG-R) inhibitors, are widely used to lower cholesterol, nevertheless, they have several side effects. Consequently, the present study is designed to unravel the cardioprotective ro
Externí odkaz:
https://doaj.org/article/941ab47ebd094fb6bcba2aa12b5f88f1
Publikováno v:
Animals, Vol 14, Iss 22, p 3281 (2024)
The association between hyperlipidaemia and acute pancreatitis is unknown in dogs. This study aimed to investigate the association between hyperlipidaemia and other markers of cholestasis in dogs with suspect acute pancreatitis. Case records of dogs
Externí odkaz:
https://doaj.org/article/0c4b24fc86894ccd9977e1bb74c4e1b4
Autor:
Alexander R.M. Lyons, Christophe A.T. Stevens, Kanika I. Dharmayat, Dr Antonio J. Vallejo-Vaz, Kausik K. Ray
Publikováno v:
Indian Heart Journal, Vol 76, Iss , Pp S113-S116 (2024)
This is an overview of the EAS Familial Hypercholesterolaemia (FH) Studies Collaboration (FHSC) global consortium and registry (established 2015), which broadly addresses the global burden of FH. Eighty-seven National Lead Investigators from 74 count
Externí odkaz:
https://doaj.org/article/ff5a3c96af4e49b9a4e2828c6f587772
Autor:
Shijiang Huang, Yuanjun Jiang, Jing Li, Linlin Mao, Zeyou Qiu, Sheng Zhang, Yuhui Jiang, Yong Liu, Wen Liu, Zhi Xiong, Wuju Zhang, Xiaolin Liu, Yue Zhang, Xiaochun Bai, Bin Guo
Publikováno v:
Advanced Science, Vol 11, Iss 24, Pp n/a-n/a (2024)
Abstract Hypercholesterolaemia is a systemic metabolic disease, but the role of organs other than liver in cholesterol metabolism is unappreciated. The phenotypic characterization of the Tsc1Dmp1 mice reveal that genetic depletion of tuberous scleros
Externí odkaz:
https://doaj.org/article/30222f7921e948be900a413f7b1702d1
Autor:
Dimitrios Terentes-Printzios, Ioanna Dima, Panorios Benardos, Panagiota Mitrou, Konstantinos Mathioudakis, Anastasios Tsolakidis, Fotios Barkas, Konstantinos Tsioufis, Petros P. Sfikakis, Evangelos Liberopoulos, Charalambos Vlachopoulos
Publikováno v:
International Journal of Cardiology. Cardiovascular Risk and Prevention, Vol 21, Iss , Pp 200261- (2024)
Background: Despite recent guidelines appropriate lipid-lowering treatment (LLT) remains suboptimal in everyday clinical practice. Aims: We aimed to describe clinical practice of use of LLT for at least high CV risk populations in a Hellenic real-wor
Externí odkaz:
https://doaj.org/article/cecf0301839b4715b511b4b0c35a9f1d
Autor:
Johanes Dedi Kanchau, Ralph Kwame Akyea, Noorhida Baharudin, Mohamed-Syarif Mohamed-Yassin, Aisyah Kamal, Yung-An Chua, Aimi Zafira Razman, Hasidah Abdul-Hamid, Suraya Abdul-Razak, Siti Fatimah Badlishah-Sham, Aznida Firzah Abdul Aziz, Nadeem Qureshi, Anis Safura Ramli
Publikováno v:
Clinical Epidemiology and Global Health, Vol 27, Iss , Pp 101619- (2024)
Background: Adults with severely elevated low-density lipoprotein cholesterol (LDL-c) may have familial hypercholesterolaemia (FH) and are at high risk of atherosclerotic cardiovascular disease (ASCVD). The prevalence of elevated LDL-c in primary car
Externí odkaz:
https://doaj.org/article/2c5ccf0eb9064363847b9cb3e9ee6bda