Zobrazeno 1 - 10
of 53
pro vyhledávání: '"hyper-phosphorylation"'
Autor:
Yao Sun, Yongqing Guo, Xuejian Feng, Meng Jia, Ning Ai, Yue Dong, Yayuan Zheng, Lu Fu, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kong
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-18 (2020)
Abstract Background Tau hyper-phosphorylation has been considered a major contributor to neurodegeneration in Alzheimer’s disease (AD) and related tauopathies, and has gained prominence in therapeutic development for AD. To elucidate the pathogenic
Externí odkaz:
https://doaj.org/article/2a348f92808f4416875fba58e9d047ae
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Almost 50 million people in the world are affected by dementia; the most prevalent form of which is Alzheimer’s disease (AD). Although aging is considered to be the main risk factor for AD, growing evidence from epidemiological studies suggests tha
Externí odkaz:
https://doaj.org/article/7cf7444eab8b46afa1f9d4179bd9c991
Autor:
Pravin D Potdar, Aashutosh U Shetti
Publikováno v:
AIMS Neuroscience, Vol 3, Iss 4, Pp 433-453 (2016)
Alzheimer’s disease (AD) has been discovered before the century but scientists still have not found the way to cure the disease. The basic requirement for successful cure requires the early diagnosis of the disease. Presence of Aβ42, total tau pro
Externí odkaz:
https://doaj.org/article/213513f7b38545a99e1fe7af80a2705f
Publikováno v:
Neural Regeneration Research, Vol 11, Iss 9, Pp 1506-1511 (2016)
Tau, a primary component of microtubule-associated protein, promotes microtubule assembly and/or disassembly and maintains the stability of the microtubule structure. Although the importance of tau in neurodegenerative diseases has been well demonstr
Externí odkaz:
https://doaj.org/article/9df0bda6838c42f6bd530be553c76b7f
Publikováno v:
Virology
Viruses exploit phosphorylation of both viral and host proteins to support viral replication. In this study, we demonstrate that porcine reproductive and respiratory syndrome virus replicase nsp2, and two nsp2-related -2/-1 frameshifting products, ns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8078c2d967f1e24a0fed9192bfc3930b
http://europepmc.org/articles/PMC7112050
http://europepmc.org/articles/PMC7112050
Autor:
Ning Ai, Meng Jia, Yayuan Zheng, Haihong Zhang, Lu Fu, Yao Sun, Jiaxin Wu, Hui Wu, Xianghui Yu, Yongqing Guo, Xuejian Feng, Bin Yu, Wei Kong, Yue Dong
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-18 (2020)
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-18 (2020)
Background Tau hyper-phosphorylation has been considered a major contributor to neurodegeneration in Alzheimer’s disease (AD) and related tauopathies, and has gained prominence in therapeutic development for AD. To elucidate the pathogenic mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ced72c35805bd94b0c69bf78e6663b
https://doi.org/10.1186/s12974-020-01749-w
https://doi.org/10.1186/s12974-020-01749-w
Autor:
Marika Lanza, Emanuela Esposito, Giovanna Casili, Salvatore Cuzzocrea, Alessia Filippone, Irene Paterniti, Michela Campolo
Publikováno v:
Journal of Cellular and Molecular Medicine
Alzheimer disease (AD) is characterized by a complex heterogeneity of pathological changes, and any therapeutic approach categorically requires a multi‐targeted way. It has been demonstrated that together with the hallmarks of the disease such as n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad972063e6c0f28842ec04582e0679c0
https://doi.org/10.1111/jcmm.13358
https://doi.org/10.1111/jcmm.13358
Publikováno v:
Neural Regeneration Research
Neural Regeneration Research, Vol 11, Iss 9, Pp 1506-1511 (2016)
Neural Regeneration Research, Vol 11, Iss 9, Pp 1506-1511 (2016)
Tau, a primary component of microtubule-associated protein, promotes microtubule assembly and/or disassembly and maintains the stability of the microtubule structure. Although the importance of tau in neurodegenerative diseases has been well demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ede7752a19580154e1574a1074a5ca
http://europepmc.org/articles/PMC5090857
http://europepmc.org/articles/PMC5090857
Autor:
Aashutosh Shetti, Pravin D. Potdar
Publikováno v:
AIMS Neuroscience, Vol 3, Iss 4, Pp 433-453 (2016)
Alzheimer’s disease (AD) has been discovered before the century but scientists still have not found the way to cure the disease. The basic requirement for successful cure requires the early diagnosis of the disease. Presence of Aβ42, total tau pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56569edfa3b458bed1d265dd269dad35
https://doi.org/10.3934/neuroscience.2016.4.433
https://doi.org/10.3934/neuroscience.2016.4.433
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