Hydrophobic mismatch drives self-organization of designer proteins into synthetic membranes

Autor: Justin A. Peruzzi, Jan Steinkühler, Timothy Q. Vu, Taylor F. Gunnels, Vivian T. Hu, Peilong Lu, David Baker, Neha P. Kamat

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract The organization of membrane proteins between and within membrane-bound compartments is critical to cellular function. Yet we lack approaches to regulate this organization in a range of membrane-based materials, such as engineered cells, exo

Externí odkaz: https://doaj.org/article/dd904c5a265f4a8588ba54371b068b97

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Hydrophobic mismatch and sequence specificity compete when transmembrane helix-helix interactions are measured with the TOXCAT assay

Autor: Nadja Hellmann, Dirk Schneider

Publikováno v: Frontiers in Chemistry, Vol 10 (2022)

Genetic assays capable of measuring the propensity of transmembrane helices to oligomerize within the cytoplasmic membrane of the bacterium E. coli are frequently used when sequence-specificity in transmembrane helix-helix interactions is investigate

Externí odkaz: https://doaj.org/article/91da12ce71a044e28bb231fe59a189e9

TatA and TatB generate a hydrophobic mismatch important for the function and assembly of the Tat translocon in Escherichia coli

Autor: Mehner-Breitfeld, Denise, Ringel, Michael T., Tichy, Daniel Alexander, Endter, Laura J., Stroh, Kai Steffen, Lünsdorf, Heinrich, Risselada, Herre Jelger, Brüser, Thomas

Publikováno v: In Journal of Biological Chemistry September 2022 298(9)

The AAA+ protein Msp1 recognizes substrates by a hydrophobic mismatch.

Autor: Fresenius HL; Previously at University of Toledo, Department of Chemistry & Biochemistry., Gaur D; Previously at University of Toledo, Department of Chemistry & Biochemistry.; University of Pittsburgh, Department of Cell Biology., Smith B; Previously at University of Toledo, Department of Chemistry & Biochemistry.; University of Pittsburgh, Department of Cell Biology., Acquaviva B; University of Pittsburgh, Department of Cell Biology., Wohlever ML; Previously at University of Toledo, Department of Chemistry & Biochemistry.; University of Pittsburgh, Department of Cell Biology.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 29. Date of Electronic Publication: 2024 Sep 29.