Zobrazeno 1 - 10
of 28 691
pro vyhledávání: '"huntington's disease"'
Autor:
Sunniva M. K. Bøstrand, Luise A. Seeker, Nadine Bestard-Cuche, Nina-Lydia Kazakou, Sarah Jäkel, Boyd Kenkhuis, Neil C. Henderson, Susanne T. de Bot, Willeke M. C. van Roon-Mom, Josef Priller, Anna Williams
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease with a fatal outcome. There is accumulating evidence of a prominent role of glia in the pathology of HD, and we investigated this by conducting single nuclear RNA
Externí odkaz:
https://doaj.org/article/481020d6c0a242d9bbb0b2caef4a4421
Autor:
Nicholas S. Caron, Lauren M. Byrne, Fanny L. Lemarié, Jeffrey N. Bone, Amirah E.-E. Aly, Seunghyun Ko, Christine Anderson, Lorenzo L. Casal, Austin M. Hill, David J. Hawellek, Peter McColgan, Edward J. Wild, Blair R. Leavitt, Michael R. Hayden
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-22 (2024)
Abstract Background Therapeutic approaches aimed at lowering toxic mutant huntingtin (mHTT) levels in the brain can reverse disease phenotypes in animal models of Huntington's disease (HD) and are currently being evaluated in clinical trials. Sensiti
Externí odkaz:
https://doaj.org/article/89b2e043ae1a4ef094cfbb9512ed2741
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Huntington’s disease (HD) is a hereditary neurological disorder caused by mutations in HTT, leading to neuronal degeneration. Traditionally, HD is associated with the misfolding and aggregation of mutant huntingtin due to an ext
Externí odkaz:
https://doaj.org/article/067d53e951d9447594406bde3be539bd
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-21 (2024)
Abstract Background Huntington’s disease (HD) is a progressive neurodegenerative disease that causes motor, cognitive, and psychiatric abnormalities, with no satisfying disease-modifying therapy so far. 3-nitropropionic acid (3NP) induces behaviour
Externí odkaz:
https://doaj.org/article/48965ea6c89941fe881f2cbe93833b5e
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Huntington’s disease (HD) is a rare neurodegenerative disease caused due to aggregation of Huntingtin (HTT) protein. This study involves the cloning of 40 DnaJ chaperones from Drosophila, and overexpressing them in yeasts and fly models of
Externí odkaz:
https://doaj.org/article/f23e0c0101c14016a2d49203166a839b
Autor:
Matthew C. L. Phillips, Martin Picard
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-21 (2024)
Abstract Neurodegenerative disorders are typically “split” based on their hallmark clinical, anatomical, and pathological features, but they can also be “lumped” by a shared feature of impaired mitochondrial biology. This leads us to present
Externí odkaz:
https://doaj.org/article/975a5dad0c274bd5b2465f336718f6ca
Autor:
Tien-Chang Lin, Orion Shih, Tien-Ying Tsai, Yi-Qi Yeh, Kuei-Fen Liao, Bradley W. Mansel, Ying-Jen Shiu, Chi-Fon Chang, An-Chung Su, Yun-Ru Chen, U-Ser Jeng
Publikováno v:
IUCrJ, Vol 11, Iss 5, Pp 849-858 (2024)
The aberrant fibrillization of huntingtin exon 1 (Httex1) characterized by an expanded polyglutamine (polyQ) tract is a defining feature of Huntington's disease, a neurodegenerative disorder. Recent investigations underscore the involvement of a smal
Externí odkaz:
https://doaj.org/article/209dc44d9cfb417082cdde097083b7a8