Zobrazeno 1 - 10
of 276
pro vyhledávání: '"humanized mouse models"'
Autor:
M.I. Lucena, M. Villanueva-Paz, I. Alvarez-Alvarez, G.P. Aithal, E.S. Björnsson, G. Cakan-Akdogan, F.J. Cubero, F. Esteves, J.M. Falcon-Perez, B. Fromenty, C. Garcia-Ruiz, J.I. Grove, O. Konu, M. Kranendonk, G.A. Kullak-Ublick, J.P. Miranda, A. Remesal-Doblado, P. Sancho-Bru, L. Nelson, R.J. Andrade, A.K. Daly, J.C. Fernandez-Checa
Publikováno v:
Pharmacological Research, Vol 200, Iss , Pp 107046- (2024)
In the current article the aims for a constructive way forward in Drug-Induced Liver Injury (DILI) are to highlight the most important priorities in research and clinical science, therefore supporting a more informed, focused, and better funded futur
Externí odkaz:
https://doaj.org/article/2c7c8e11fae04b7f942b7aa0a4dabc81
Autor:
Paula Martinez-Sanz, Adrien R. G. Laurent, Edith Slot, Mark Hoogenboezem, Nikolina Bąbała, Robin van Bruggen, Anthony Rongvaux, Richard A. Flavell, Godelieve A. M. Tytgat, Katka Franke, Hanke L. Matlung, Taco W. Kuijpers, Derk Amsen, Julien J. Karrich
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMISTRG mice have been genetically modified to allow development of a human myeloid compartment from engrafted human CD34+ haemopoietic stem cells, making them particularly suited to study the human innate immune system in vivo. Here, we c
Externí odkaz:
https://doaj.org/article/6f2a3ef6081c4018ae68e848da1ea48c
Autor:
Lena Immisch, George Papafotiou, Nerea Gallarín Delgado, Vivian Scheuplein, Annette Paschen, Thomas Blankenstein, Gerald Willimsky
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Recurrent neoepitopes are cancer-specific antigens common among groups of patients and therefore ideal targets for adoptive T cell therapy. The neoepitope FSGEYIPTV carries the Rac1P29S amino acid change caused by a c.85C>T missense mutation, which i
Externí odkaz:
https://doaj.org/article/ed394da54e544d6e923619bf5e6c2076
Autor:
Noemi Alejandra Saavedra-Avila, Paolo Dellabona, Giulia Casorati, Natacha Veerapen, Gurdyal S. Besra, Amy R. Howell, Steven A. Porcelli
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Invariant natural killer T (iNKT) cells mediate immune responses when stimulated by glycolipid agonists presented by CD1d. In extensive studies of synthetic analogues of α-galactosyl ceramides, we identified numerous examples of significant differen
Externí odkaz:
https://doaj.org/article/5d32e342b826403ea225e6efd39248ae
Autor:
Bijun Zeng, Davide Moi, Lynn Tolley, Natalie Molotkov, Ian Hector Frazer, Christopher Perry, Riccardo Dolcetti, Roberta Mazzieri, Jazmina L. G. Cruz
Publikováno v:
Cells, Vol 12, Iss 16, p 2094 (2023)
Vaccines have been hailed as one of the most remarkable medical advancements in human history, and their potential for treating cancer by generating or expanding anti-tumor T cells has garnered significant interest in recent years. However, the limit
Externí odkaz:
https://doaj.org/article/aafd8b19e27c4a3c90cb5e2e543767c8
Autor:
Melissa Xin Yu Wong, Qingfeng Chen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/d078ce78788d4f02a8785012436404cf
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal bone-marrow diseases with ineffective hematopoiesis resulting in cytopenias and morphologic dysplasia of hematopoietic cells. MDS carry a wide spectrum of genetic abnormalities, rang
Externí odkaz:
https://doaj.org/article/fb326ed236504478b4cc24d7e74cfc51
Autor:
Axel Ducret, Chloé Ackaert, Juliana Bessa, Campbell Bunce, Timothy Hickling, Vibha Jawa, Mark A. Kroenke, Kasper Lamberth, Anaïs Manin, Hweixian L. Penny, Noel Smith, Grzegorz Terszowski, Sophie Tourdot, Sebastian Spindeldreher
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
A major impediment to successful use of therapeutic protein drugs is their ability to induce anti-drug antibodies (ADA) that can alter treatment efficacy and safety in a significant number of patients. To this aim, in silico, in vitro, and in vivo to
Externí odkaz:
https://doaj.org/article/f1b08d7387d549058b5c20457db22f6b
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Graft-vs-host disease (GVHD) is the most common cause of non-relapse mortality following allogeneic hematopoietic stem cell transplantation (HSCT) despite advances in conditioning regimens, HLA genotyping and immune suppression. While murine studies
Externí odkaz:
https://doaj.org/article/3d1b8617dfae413ea2befb82ca647e9b
Autor:
Violetta S. Gogoleva, Kamar-Sulu N. Atretkhany, Arina P. Dygay, Taisiya R. Yurakova, Marina S. Drutskaya, Sergei A. Nedospasov
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
TNF is a multifunctional cytokine with its key functions attributed to inflammation, secondary lymphoid tissue organogenesis and immune regulation. However, it is also a physiological regulator of hematopoiesis and is involved in development and home
Externí odkaz:
https://doaj.org/article/8071f092f50f4f48a84c52deb295146c