Zobrazeno 1 - 10
of 634
pro vyhledávání: '"humanized mouse model"'
Autor:
Yumeng Li, Asha Ashuo, Menghan Hao, Yaming Li, Jianyu Ye, Jiangxia Liu, Ting Hua, Zhong Fang, Jianhua Li, Zhenghong Yuan, Jieliang Chen
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTType I interferons (IFN-Is) have key roles in immune defense and treatments for various diseases, including chronic hepatitis B virus (HBV) infection. All IFN-Is signal through a shared IFN-I heterodimeric receptor complex comprising IFN-α r
Externí odkaz:
https://doaj.org/article/584245a197254b2f9841523b625f2f65
Autor:
Ming Jin, Jiajia Lin, Haisen Li, Zhifang Li, Dong Yang, Yin Wang, Yuyang Yu, Zhurui Shao, Long Chen, Zhiqiang Wang, Yu Zhang, Xiumei Zhang, Ning Wang, Chunlong Xu, Hui Yang, Wan-Jin Chen, Guoling Li
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102165- (2024)
Duchenne muscular dystrophy (DMD) is the most prevalent herediatry disease in men, characterized by dystrophin deficiency, progressive muscle wasting, cardiac insufficiency, and premature mortality, with no effective therapeutic options. Here, we inv
Externí odkaz:
https://doaj.org/article/6f186ef33187408b9a168be14372b3e3
Autor:
José Alejandro Bohórquez, Sitaramaraju Adduri, Danish Ansari, Sahana John, Jon Florence, Omoyeni Adejare, Gaurav Singh, Nagarjun V. Konduru, Chinnaswamy Jagannath, Guohua Yi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), continues to be a major public health problem worldwide. The human immunodeficiency virus (HIV) is another equally important life-threatening pathogen. HIV infection decreases C
Externí odkaz:
https://doaj.org/article/752bd6e80b5c40a1b4f45441275f46a8
Autor:
Yaqing Shu, Fuhua Peng, Bingchu Zhao, Chunxin Liu, Qihui Li, Huilu Li, Yuge Wang, Yanjun Jiang, Tingting Lu, Qin Wang, Jian Sun, Huiyu Feng, Zhengqi Lu, Xiaodong Liu, Jie Wang, Wei Qiu
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune neuropsychiatric disease. Brain access of anti-NMDAR autoantibody through the blood–brain barrier (BBB) is essential for pathogenesis. Most previous
Externí odkaz:
https://doaj.org/article/b068a0b84c1546ac8ffea305e7420bae
Publikováno v:
Translation, Vol 11, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/d34354fdd52d4894b44b8a5f71db0445
Autor:
Yohei Sato, Abinaya Nathan, Suzette Shipp, John Fraser Wright, Keri Marie Tate, Prachi Wani, Maria-Grazia Roncarolo, Rosa Bacchetta
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101150- (2023)
Forkhead box P3 (FOXP3) is an essential transcription factor for regulatory T cell (Treg) function. Defects in Tregs mediate many immune diseases including the monogenic autoimmune disease immune dysregulation, polyendocrinopathy, enteropathy, X-link
Externí odkaz:
https://doaj.org/article/4857ed24484f46b1a8ddb706e314c3fb
Autor:
Qian Wu, Ling Zhong, Dongmei Wei, Wanlin Zhang, Junping Hong, Yinfeng Kang, Kaiyun Chen, Yang Huang, Qingbing Zheng, Miao Xu, Mu-Sheng Zeng, Yi-Xin Zeng, Ningshao Xia, Qinjian Zhao, Claude Krummenacher, Yixin Chen, Xiao Zhang
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Epstein–Barr virus (EBV) is the first reported human oncogenic virus and infects more than 95% of the human population worldwide. EBV latent infection in B lymphocytes is essential for viral persistence. Glycoprotein gp42 is an indispensable member
Externí odkaz:
https://doaj.org/article/747ee2b902cd4ff299fa9555e40b298a
Publikováno v:
Acta Dermato-Venereologica, Vol 103 (2023)
Abstract is missing (Short communication)
Externí odkaz:
https://doaj.org/article/b972c799d63e4c4fa28c3c24c7645281
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The advent of novel cancer immunotherapy approaches is revolutionizing the treatment for cancer. Current small animal models for most cancers are syngeneic or genetically engineered mouse models or xenograft models based on immunodeficient mouse stra
Externí odkaz:
https://doaj.org/article/f402a5c130be44809bb32c4836fada52
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 54, Pp 1497-1506 (2022)
The establishment of an in vivo mouse model mimicking human tumor-immune environments provides a promising platform for immunotherapy assessment, drug discovery and clinical decision guidance. To this end, we construct humanized NCG mice by transplan
Externí odkaz:
https://doaj.org/article/f499c0f5fe874a22acd7caf19f8af086