Zobrazeno 1 - 10
of 3 344
pro vyhledávání: '"human pluripotent stem cells"'
Autor:
Elisa Zanfrini, Manuj Bandral, Luka Jarc, Maria Alejandra Ramirez-Torres, Daniela Pezzolla, Vida Kufrin, Eva Rodriguez-Aznar, Ana Karen Mojica Avila, Christian Cohrs, Stephan Speier, Katrin Neumann, Anthony Gavalas
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The significant advances in the differentiation of human pluripotent stem (hPS) cells into pancreatic endocrine cells, including functional β-cells, have been based on a detailed understanding of the underlying developmental mechanisms. How
Externí odkaz:
https://doaj.org/article/29312b1f86b841f09af33ee6d30fc804
Autor:
Ingrid Wilhelmsen, Thomas Combriat, Andrea Dalmao-Fernandez, Justyna Stokowiec, Chencheng Wang, Petter Angell Olsen, Jonas Aakre Wik, Yuliia Boichuk, Aleksandra Aizenshtadt, Stefan Krauss
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Hepatic stellate cells (HSC) have numerous critical roles in liver function and homeostasis, while they are also known for their importance during liver injury and fibrosis. There is therefore a need for relevant in vitro human HS
Externí odkaz:
https://doaj.org/article/dbbe1592310a4cfd8a57b7b979f5324e
Autor:
Jeffrey Aalders, Laurens Léger, Behrouz Hassannia, Vera Goossens, Tom Vanden Berghe, Jolanda van Hengel
Publikováno v:
Regenerative Therapy, Vol 27, Iss , Pp 21-31 (2024)
Generation of cardiomyocytes from human pluripotent stem cells (hPSCs) is of high interest for disease modelling and regenerative medicine. hPSCs can provide an unlimited source of patient-specific cardiomyocytes that are otherwise difficult to obtai
Externí odkaz:
https://doaj.org/article/560e0a859b58470e9d2823b7cf229719
Publikováno v:
IBRO Neuroscience Reports, Vol 16, Iss , Pp 497-508 (2024)
Microglia, resident immune cells of the brain that originate from the yolk sac, play a critical role in maintaining brain homeostasis by monitoring and phagocytosing pathogens and cellular debris in the central nervous system (CNS). While they share
Externí odkaz:
https://doaj.org/article/dfaeab5c5fbd4d2e98a419d02ad200cb
Autor:
Ruiyang Ma, Huanjing Bi, Ying Wang, Jingwen Wang, Jiangwei Zhang, Xiaoyang Yu, Zuhan Chen, Jiale Wang, Cuinan Lu, Jin Zheng, Yang Li, Xiaoming Ding
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Optimizing the efficiency of definitive endoderm (DE) differentiation is necessary for the generation of diverse organ-like structures. In this study, we used the small molecule inhibitor saracatinib (SAR) to enhance DE differentiation of hu
Externí odkaz:
https://doaj.org/article/b2d0dbd19811407d92e530016627af80
Autor:
Paul A. De Sousa, Leo Perfect, Jinpei Ye, Kay Samuels, Ewa Piotrowska, Martin Gordon, Ryan Mate, Elsa Abranches, Thomas M. Wishart, David H. Dockrell, Aidan Courtney
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background Hyaluronan (HA) is an extracellular glycosaminoglycan polysaccharide with widespread roles throughout development and in healthy and neoplastic tissues. In pluripotent stem cell culture it can support both stem cell renewal and di
Externí odkaz:
https://doaj.org/article/bf13acb1260e4f5080469f86cb5609f0
Autor:
Mu Seog Choe, Han Cheol Yeo, Joong Sun Kim, Jean Lee, Hae Jun Lee, Hyung-Ryong Kim, Kyung Min Baek, Na-Yeon Jung, Murim Choi, Min Young Lee
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Cerebral organoids (COs) are the most advanced in vitro models that resemble the human brain. The use of COs as a model for Alzheimer’s disease (AD), as well as other brain diseases, has recently gained attention. This study aim
Externí odkaz:
https://doaj.org/article/b4e6d60e5bf1414d8b0d6636e52e06e0
Autor:
Yingqi Li, Jinjin Duan, You Li, Meihui Zhang, Jiaan Wu, Guanhao Wang, Shuanqing Li, Zhangsen Hu, Yi Qu, Yunhe Li, Xiran Hu, Fei Guo, Lining Cao, Jianfeng Lu
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Background The detailed transcriptomic profiles during human serotonin neuron (SN) differentiation remain elusive. The establishment of a reporter system based on SN terminal selector holds promise to produce highly-purified cells with an ea
Externí odkaz:
https://doaj.org/article/06e6e4f9f65a44be8acc6c99549514a4
Autor:
Kaneyasu Nishimura, Hironobu Osaki, Kotaro Tezuka, Daisuke Nakashima, Shintaro Numata, Yoshito Masamizu
Publikováno v:
Frontiers in Neural Circuits, Vol 18 (2024)
Recent advances in human pluripotent stem cell (hPSC) technologies have prompted the emergence of new research fields and applications for human neurons and brain organoids. Brain organoids have gained attention as an in vitro model system that recap
Externí odkaz:
https://doaj.org/article/506dcb9d835843a18fafd931d3f589e5
Autor:
Mingming Zhao, Yukimasa Taniguchi, Chisei Shimono, Tatsuya Jonouchi, Yushen Cheng, Yasuhiro Shimizu, Minas Nalbandian, Takuya Yamamoto, Masato Nakagawa, Kiyotoshi Sekiguchi, Hidetoshi Sakurai
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Human‐induced pluripotent stem cells (hiPSCs) have great therapeutic potential. The cell source differentiated from hiPSCs requires xeno‐free and robust methods for lineage‐specific differentiation. Here, a system is described for diff
Externí odkaz:
https://doaj.org/article/40e931d2849540e8aada2992c2202ab6