Zobrazeno 1 - 10
of 3 331
pro vyhledávání: '"human pluripotent stem cells"'
Autor:
Jan Wolnik, Patrycja Adamska, Aleksandra Oleksy, Anna Magdalena Sanetra, Katarzyna Palus-Chramiec, Marian Henryk Lewandowski, Józef Dulak, Monika Biniecka
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects not only the joints but also has significant cardiovascular (CV) manifestations. The mechanistic interplay between RA and cardiovascular complications is not
Externí odkaz:
https://doaj.org/article/2db2a3a2e82c42369e3e8dc261d17dd5
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background The histone-lysine N-methyltransferase SMYD1, which is specific to striated muscle, plays a crucial role in regulating early heart development. Its deficiency has been linked to the occurrence of congenital heart disease. Neverthe
Externí odkaz:
https://doaj.org/article/900b3d2aba744013ae638df866c7e395
Comparison of human pluripotent stem cell differentiation protocols to generate neuroblastoma tumors
Autor:
Bo Cheng, Wanqi Fang, Steven Pastor, Alexander R. March, Tania Porras, Hong-Wei Wu, Miriam Velez, Chintan Parekh, John M. Maris, Shahab Asgharzadeh, Miller Huang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Neuroblastoma is the most common pediatric extracranial solid tumor and is derived from trunk neural crest cells (tNCC) and its progenitor sympathoadrenal (SA) cells. While human pluripotent stem cell (PSC) models of neuroblastoma have been
Externí odkaz:
https://doaj.org/article/8060f3e4246446d5ad9a05f143d8aa9b
Autor:
Jeffrey Aalders, Laurens Léger, Behrouz Hassannia, Vera Goossens, Tom Vanden Berghe, Jolanda van Hengel
Publikováno v:
Regenerative Therapy, Vol 27, Iss , Pp 21-31 (2024)
Generation of cardiomyocytes from human pluripotent stem cells (hPSCs) is of high interest for disease modelling and regenerative medicine. hPSCs can provide an unlimited source of patient-specific cardiomyocytes that are otherwise difficult to obtai
Externí odkaz:
https://doaj.org/article/560e0a859b58470e9d2823b7cf229719
Autor:
Elisa Zanfrini, Manuj Bandral, Luka Jarc, Maria Alejandra Ramirez-Torres, Daniela Pezzolla, Vida Kufrin, Eva Rodriguez-Aznar, Ana Karen Mojica Avila, Christian Cohrs, Stephan Speier, Katrin Neumann, Anthony Gavalas
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The significant advances in the differentiation of human pluripotent stem (hPS) cells into pancreatic endocrine cells, including functional β-cells, have been based on a detailed understanding of the underlying developmental mechanisms. How
Externí odkaz:
https://doaj.org/article/29312b1f86b841f09af33ee6d30fc804
Autor:
Ingrid Wilhelmsen, Thomas Combriat, Andrea Dalmao-Fernandez, Justyna Stokowiec, Chencheng Wang, Petter Angell Olsen, Jonas Aakre Wik, Yuliia Boichuk, Aleksandra Aizenshtadt, Stefan Krauss
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Hepatic stellate cells (HSC) have numerous critical roles in liver function and homeostasis, while they are also known for their importance during liver injury and fibrosis. There is therefore a need for relevant in vitro human HS
Externí odkaz:
https://doaj.org/article/dbbe1592310a4cfd8a57b7b979f5324e
Publikováno v:
IBRO Neuroscience Reports, Vol 16, Iss , Pp 497-508 (2024)
Microglia, resident immune cells of the brain that originate from the yolk sac, play a critical role in maintaining brain homeostasis by monitoring and phagocytosing pathogens and cellular debris in the central nervous system (CNS). While they share
Externí odkaz:
https://doaj.org/article/dfaeab5c5fbd4d2e98a419d02ad200cb
Autor:
Kim Jee Goh, Hao Lu, Ee Kim Tan, Zhao Yong Lee, Amanda Wong, Thai Tran, N. Ray Dunn, Sudipto Roy
Publikováno v:
Biology Open, Vol 13, Iss 10 (2024)
Externí odkaz:
https://doaj.org/article/dd8e10c37f2244859421cecdf8fd9324
Autor:
Sin-Ruow Tey, Ryan S. Anderson, Clara H. Yu, Samantha Robertson, Heidi Kletzien, Nadine P. Connor, Kaori Tanaka, Yasuyuki Ohkawa, Masatoshi Suzuki
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
IntroductionThe changing composition of non-cell autonomous circulating factors in blood as humans age is believed to play a role in muscle mass and strength loss. The mechanisms through which these circulating factors act in age-related skeletal mus
Externí odkaz:
https://doaj.org/article/4298b9abc6734f688002034d2b96e095
Autor:
Mengdan Tao, Can Wang, Zhilong Zheng, Weiwei Gao, Qi Chen, Min Xu, Wanying Zhu, Lei Xu, Xiao Han, Xing Guo, Yan Liu
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 285, Iss , Pp 117063- (2024)
Nanoplastics are ubiquitous in our daily lives, raising concerns about their potential impact on the human brain. Many studies reported that nanoplastics permeate the blood-brain barrier and influence cellular processes in mouse models. However, the
Externí odkaz:
https://doaj.org/article/18ed712105504e59848b6e059bbddf6b