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Healthy but not osteoarthritic human meniscus-derived matrix scaffolds promote meniscus repair

Autor: Saman Firoozi, Jon C. Ley, Dawn A. D. Chasse, David E. Attarian, Samuel S. Wellman, Annunziato Amendola, Amy L. McNulty

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)

Meniscus tissue is commonly injured due to sports-related injuries and age-related degeneration and approximately 50% of individuals with a meniscus tear will develop post-traumatic osteoarthritis (PTOA). Given that the meniscus has limited healing p

Externí odkaz: https://doaj.org/article/76c5b6e87a694c4987f9f84e80e82253

Short-term response of primary human meniscus cells to simulated microgravity

Autor: Zhiyao Ma, David Xinzheyang Li, Xiaoyi Lan, Adam Bubelenyi, Margaret Vyhlidal, Melanie Kunze, Mark Sommerfeldt, Adetola B. Adesida

Publikováno v: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-12 (2024)

Abstract Background Mechanical unloading of the knee articular cartilage results in cartilage matrix atrophy, signifying the osteoarthritic-inductive potential of mechanical unloading. In contrast, mechanical loading stimulates cartilage matrix produ

Externí odkaz: https://doaj.org/article/a910cd89ada64d5eae23eda1dc460bbe

Author Correction: Mechanical Unloading of Engineered Human Meniscus Models Under Simulated Microgravity: A Transcriptomic Study.

Autor: Ma Z; Department of Surgery, Division of Orthopaedic Surgery, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, T6G 2E1, Canada., Li DX; Department of Surgery, Division of Orthopaedic Surgery, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, T6G 2E1, Canada.; Department of Civil & Environmental Engineering, University of Alberta, Edmonton, AB, Canada., Chee RKW; Department of Surgery, Division of Orthopaedic Surgery, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, T6G 2E1, Canada., Kunze M; Department of Surgery, Division of Orthopaedic Surgery, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, T6G 2E1, Canada., Mulet-Sierra A; Department of Surgery, Division of Orthopaedic Surgery, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, T6G 2E1, Canada., Sommerfeldt M; Department of Surgery, Division of Orthopaedic Surgery, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, T6G 2E1, Canada., Westover L; Department of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada., Graf D; School of Dentistry, University of Alberta, Edmonton, AB, Canada., Adesida AB; Department of Surgery, Division of Orthopaedic Surgery, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, T6G 2E1, Canada. adesida@ualberta.ca.

Publikováno v: Scientific data [Sci Data] 2024 Oct 10; Vol. 11 (1), pp. 1109. Date of Electronic Publication: 2024 Oct 10.

“Slow walk” mimetic tensile loading maintains human meniscus tissue resident progenitor cells homeostasis in photocrosslinked gelatin hydrogel

Autor: Sun, Jing, Chan, Yau Tsz, Ho, Ki Wai Kevin, Zhang, Li, Bian, Liming, Tuan, Rocky S., Jiang, Yangzi

Publikováno v: In Bioactive Materials July 2023 25:256-272