AZD6738 Inhibits fibrotic response of conjunctival fibroblasts by regulating checkpoint kinase 1/P53 and PI3K/AKT pathways

Autor: Longxiang Huang, Qin Ye, Chunlin Lan, Xiaohui Wang, Yihua Zhu

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Trabeculectomy can effectively reduce intraocular pressure (IOP) in glaucoma patients, the long-term surgical failure is due to the excessive proliferation and fibrotic response of conjunctival fibroblasts which causes the subconjunctival scar and no

Externí odkaz: https://doaj.org/article/3e721ac553d1454fa8428244686986fd

Sulforaphane modulates TGFβ2-induced conjunctival fibroblasts activation and fibrosis by inhibiting PI3K/Akt signaling

Autor: Zi-Yao Xia, Han-Ruo Liu, Ning-Li Wang

Publikováno v: International Journal of Ophthalmology, Vol 13, Iss 10, Pp 1505-1511 (2020)
Int J Ophthalmol

AIM: To examine the effects of sulforaphane on fibrotic changes of transforming growth factor (TGFβ2) induced human conjunctival fibroblast (HConFs). METHODS: HConFs were cultured and divided into control, TGFβ2 (1 ng/mL), sulforaphane and TGFβ2+s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6a49f91da90ae8427a9c56cc9cc75c
http://www.ijo.cn/en_publish/2020/10/20201001.pdf

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The CLC-2 Chloride Channel Modulates ECM Synthesis, Differentiation, and Migration of Human Conjunctival Fibroblasts via the PI3K/Akt Signaling Pathway

Autor: Yajuan Zheng, Lixia Sun, Yuan Yin, Jing Zhao, Yaru Dong

Publikováno v: International Journal of Molecular Sciences, Vol 17, Iss 6, p 910 (2016)
International Journal of Molecular Sciences; Volume 17; Issue 6; Pages: 910
International Journal of Molecular Sciences

Recent evidence suggests that chloride channels are critical for cell proliferation, migration, and differentiation. We examined the effects of transforming growth factor (TGF)-β1 on chloride channel expression and associations with human conjunctiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e4e313891fa31052f3cb76fedaea32
https://doi.org/10.3390/ijms17060910

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