Oxidized Low-Density Lipoprotein Induces Reactive Oxygen Species-Dependent Proliferation of Intestinal Epithelial Cells

Autor: Eddy E. Gonzalez-Horta, Juan F. Burgueno, María J. Leiva, Carla Villavicencio, Fernando I. Kawaguchi, Hajar Hazime, Fátima Reyes, Viana Manrique-Suárez, Natalie C. Parra, Maria T. Abreu, Jorge R. Toledo

Publikováno v: Pharmaceuticals, Vol 17, Iss 11, p 1466 (2024)

Background/Objectives: Oxidized low-density lipoprotein (ox-LDL) is a proinflammatory particle associated with various diseases and affects cell proliferation and viability in multiple cell types. However, its impact on intestinal epithelial cells re

Externí odkaz: https://doaj.org/article/9b3154ea1f0a4243a891dd2b3cf2eddf

Translocation of outer membrane vesicles from enterohemorrhagic Escherichia coli O157 across the intestinal epithelial barrier

Autor: Daniel Krsek, Daniel Alejandro Yara, Hana Hrbáčková, Ondřej Daniel, Andrea Mančíková, Stephanie Schüller, Martina Bielaszewska

Publikováno v: Frontiers in Microbiology, Vol 14 (2023)

Outer membrane vesicles (OMVs) carrying virulence factors of enterohemorrhagic Escherichia coli (EHEC) are assumed to play a role in the pathogenesis of life-threatening hemolytic uremic syndrome (HUS). However, it is unknown if and how OMVs, which a

Externí odkaz: https://doaj.org/article/b8a3c770a79141138cee6495e8de3f13

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Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids

Autor: Allen Lee, Jun Gao, Chung Owyang, Xu Han, Jason R. Spence, Sha Huang

Publikováno v: Gut Microbes

Disruption of intestinal barrier homeostasis is an important pathogenic factor in conditions such as irritable bowel syndrome (IBS). Lactobacillus rhamnosus GG (LGG) improves IBS symptoms through unclear mechanisms. Previous studies utilizing colorec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fdc58927771a82775643a1c8e79928d
http://europepmc.org/articles/PMC6363076

Uranium-bearing dust induces differentiation and expansion of enteroendocrine cells in human colonoids.

Autor: Atanga R; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM., Appell LL; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM., Lauer FT; Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM., Brearley A; Department of Earth and Planetary Sciences, College of Arts and Sciences, University of New Mexico, Albuquerque, NM., Campen MJ; Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM., Castillo EF; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM.; Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM., In JG; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM.; Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 10. Date of Electronic Publication: 2023 Aug 10.