Zobrazeno 1 - 10
of 56
pro vyhledávání: '"human artificial chromosome (HAC)"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 40, Iss , Pp 101875- (2024)
Gene therapy for xeroderma pigmentosum (XP), a rare, recessive DNA repair disease, has been considered since defects in XP genes result in severe and debilitating symptoms. Mutations in the XPC DNA repair gene result in a more that 1000-fold increase
Externí odkaz:
https://doaj.org/article/7b20e0a3927748f0913f8e992dd25b43
Autor:
Mikhail Liskovykh, Nikolai S. Petrov, Vladimir N. Noskov, Hiroshi Masumoto, William C. Earnshaw, David Schlessinger, Svetlana A. Shabalina, Vladimir Larionov, Natalay Kouprina
Publikováno v:
Liskovykh, M, Petrov, N S, Noskov, V N, Masumoto, H, Earnshaw, W C, Schlessinger, D, Shabalina, S A, Larionov, V & Kouprina, N 2023, ' Actively transcribed rDNA and distal junction (DJ) sequence are involved in association of NORs with nucleoli ', Cellular and Molecular Life Sciences, vol. 80, no. 5, 121 . https://doi.org/10.1007/s00018-023-04770-3
Although they are organelles without a limiting membrane, nucleoli have an exclusive structure, built upon the rDNA-rich acrocentric short arms of five human chromosomes (nucleolar organizer regions or NORs). This has raised the question: what are th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c6d0a17bc08a5f209032b9cf607d0c
https://hdl.handle.net/20.500.11820/bf60b92a-f13e-4419-90da-6aaf6adb3a3a
https://hdl.handle.net/20.500.11820/bf60b92a-f13e-4419-90da-6aaf6adb3a3a
Autor:
Sergey V. Ponomartsev, Sergey A. Sinenko, Elena V. Skvortsova, Mikhail A. Liskovykh, Ivan N. Voropaev, Maria M. Savina, Andrey A. Kuzmin, Elena Yu. Kuzmina, Alexandra M. Kondrashkina, Vladimir Larionov, Natalay Kouprina, Alexey N. Tomilin
Publikováno v:
Cells, Vol 9, Iss 4, p 879 (2020)
Human artificial chromosomes (HACs), including the de novo synthesized alphoidtetO-HAC, are a powerful tool for introducing genes of interest into eukaryotic cells. HACs are mitotically stable, non-integrative episomal units that have a large transge
Externí odkaz:
https://doaj.org/article/4f5e0539ddb941dbb6193eff810f3d45
Akademický článek
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Autor:
Sergey A. Sinenko, Elena V. Skvortsova, Mikhail A. Liskovykh, Sergey V. Ponomartsev, Andrey A. Kuzmin, Aleksandr A. Khudiakov, Anna B. Malashicheva, Natalia Alenina, Vladimir Larionov, Natalay Kouprina, Alexey N. Tomilin
Publikováno v:
Cells, Vol 7, Iss 12, p 261 (2018)
AlphoidtetO-type human artificial chromosome (HAC) has been recently synthetized as a novel class of gene delivery vectors for induced pluripotent stem cell (iPSC)-based tissue replacement therapeutic approach. This HAC vector was designed to deliver
Externí odkaz:
https://doaj.org/article/fe320cdbeceb4510ae59b59ce446545f
Autor:
Mikhail Liskovykh, Alexey Tomilin, Natalay Kouprina, Vladimir Larionov, Alexandra M Kondrashkina, Sergey A. Sinenko, Andrey A. Kuzmin, Elena V. Skvortsova, Ivan N Voropaev, Maria M Savina, Elena Kuzmina, S. V. Ponomartsev
Publikováno v:
Cells
Volume 9
Issue 4
Cells, Vol 9, Iss 879, p 879 (2020)
Volume 9
Issue 4
Cells, Vol 9, Iss 879, p 879 (2020)
Human artificial chromosomes (HACs), including the de novo synthesized alphoidtetO-HAC, are a powerful tool for introducing genes of interest into eukaryotic cells. HACs are mitotically stable, non-integrative episomal units that have a large transge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bfc728c897c5474ce591938b5aae38
Autor:
Sergey V, Ponomartsev, Sergey A, Sinenko, Elena V, Skvortsova, Mikhail A, Liskovykh, Ivan N, Voropaev, Maria M, Savina, Andrey A, Kuzmin, Elena Yu, Kuzmina, Alexandra M, Kondrashkina, Vladimir, Larionov, Natalay, Kouprina, Alexey N, Tomilin
Publikováno v:
Cells
Human artificial chromosomes (HACs), including the de novo synthesized alphoidtetO-HAC, are a powerful tool for introducing genes of interest into eukaryotic cells. HACs are mitotically stable, non-integrative episomal units that have a large transge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e056ab2f0cf526c73856f138057a80e
https://pubmed.ncbi.nlm.nih.gov/32260189
https://pubmed.ncbi.nlm.nih.gov/32260189
Autor:
Zoia L. Monaco, Daniela Moralli
Publikováno v:
Experimental Cell Research
After the construction of genomic libraries with yeast artificial chromosomes in the late 1980's for gene isolation and expression studies in cells, human artificial chromosomes were then a natural development in the 1990's, based on the same princip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5d6ed1d8cf348d1e2dbecd0620c0ae
https://pubmed.ncbi.nlm.nih.gov/32126238
https://pubmed.ncbi.nlm.nih.gov/32126238
Autor:
Vladimir Larionov, Alexey Tomilin, Natalia Alenina, Mikhail Liskovykh, Elena V. Skvortsova, S. V. Ponomartsev, Anna Malashicheva, Andrey A. Kuzmin, Natalay Kouprina, Aleksandr Khudiakov, Sergey A. Sinenko
Publikováno v:
Cells
Volume 7
Issue 12
Cells, Vol 7, Iss 12, p 261 (2018)
Volume 7
Issue 12
Cells, Vol 7, Iss 12, p 261 (2018)
AlphoidtetO-type human artificial chromosome (HAC) has been recently synthetized as a novel class of gene delivery vectors for induced pluripotent stem cell (iPSC)-based tissue replacement therapeutic approach. This HAC vector was designed to deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b23c7a5399fadbb61d9ec88ce5dfb0
https://pubmed.ncbi.nlm.nih.gov/30544831
https://pubmed.ncbi.nlm.nih.gov/30544831
Publikováno v:
Biology Methods & Protocols
A human artificial chromosome (HAC) vector has potential to overcome the problems of stable gene expression associated with plasmid, transposon, and virus-based vectors, such as insertional mutagenesis, position effect, uncontrollable copy number, un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff5035d54f3c73759c797c7d716c2d8
https://pubmed.ncbi.nlm.nih.gov/32161806
https://pubmed.ncbi.nlm.nih.gov/32161806