Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells

Autor: Kim, Jung-Hyun, Kononenko, Artem, Erliandri, Indri, Kim, Tae-Aug, Nakano, Megumi, Iida, Yuichi, Barrett, J. Carl, Oshimura, Mitsuo, Masumoto, Hiroshi, Earnshaw, William C., Larionov, Vladimir, Kouprina, Natalay

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2011 Dec . 108(50), 20048-20053.

Externí odkaz: https://www.jstor.org/stable/23060073

Co-infection of HSV-1 amplicons containing the XPC gene and a human artificial chromosome vector into primary XPC deficient fibroblast cells

Autor: Daniela Moralli, Avi Smith, Jonathan Garlick, Kenneth H. Kraemer, Zoia L. Monaco

Publikováno v: Biochemistry and Biophysics Reports, Vol 40, Iss , Pp 101875- (2024)

Gene therapy for xeroderma pigmentosum (XP), a rare, recessive DNA repair disease, has been considered since defects in XP genes result in severe and debilitating symptoms. Mutations in the XPC DNA repair gene result in a more that 1000-fold increase

Externí odkaz: https://doaj.org/article/7b20e0a3927748f0913f8e992dd25b43

Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts.

Autor: Kakeda, M.¹, Hiratsuka, M.^1,2, Nagata, K.¹, Kuroiwa, Y.¹, Kakitani, M.¹, Katoh, M.², Oshimura, M.², Tomizuka, K.²

Publikováno v: Gene Therapy. May2005, Vol. 12 Issue 10, p852-856. 5p.

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Novel screen for anti-cancer drugs that elevate chromosome instability (CIN) using human artificial chromosome (HAC).

Autor: Kouprina N; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Larionov V; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

Publikováno v: Oncotarget [Oncotarget] 2018 Dec 07; Vol. 9 (96), pp. 36833-36835. Date of Electronic Publication: 2018 Dec 07 (Print Publication: 2018).