Adeno-associated virus-mediated gene transfer of arginine decarboxylase to the central nervous system prevents opioid analgesic tolerance

Autor: Caroline C. Churchill, Cristina D. Peterson, Kelley F. Kitto, Kelsey R. Pflepsen, Lalitha R. Belur, R. Scott McIvor, Lucy Vulchanova, George L. Wilcox, Carolyn A. Fairbanks

Publikováno v: Frontiers in Pain Research, Vol 4 (2024)

Agmatine, a decarboxylated form of L-arginine, prevents opioid analgesic tolerance, dependence, and self-administration when given by both central and systemic routes of administration. Endogenous agmatine has been previously detected in the central

Externí odkaz: https://doaj.org/article/52efa26146094fbbb8d8e7459e96d505

Adeno-associated virus-mediated gene transfer of arginine decarboxylase to the central nervous system prevents opioid analgesic tolerance.

Autor: Churchill CC; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, United States., Peterson CD; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, United States.; Department of Neuroscience, University of Minnesota, Minneapolis, MN, United States.; Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, United States., Kitto KF; Department of Neuroscience, University of Minnesota, Minneapolis, MN, United States., Pflepsen KR; Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, United States., Belur LR; Department of Genetics Cell Biology and Development, University of Minnesota, Minneapolis, MN, United States., McIvor RS; Department of Genetics Cell Biology and Development, University of Minnesota, Minneapolis, MN, United States., Vulchanova L; Department of Neuroscience, University of Minnesota, Minneapolis, MN, United States., Wilcox GL; Department of Neuroscience, University of Minnesota, Minneapolis, MN, United States.; Department of Pharmacology, University of Minnesota, Minneapolis, MN, United States.; Department of Dermatology, University of Minnesota, Minneapolis, MN, United States., Fairbanks CA; Department of Neuroscience, University of Minnesota, Minneapolis, MN, United States.; Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, United States.; Department of Pharmacology, University of Minnesota, Minneapolis, MN, United States.

Publikováno v: Frontiers in pain research (Lausanne, Switzerland) [Front Pain Res (Lausanne)] 2024 Feb 09; Vol. 4, pp. 1269017. Date of Electronic Publication: 2024 Feb 09 (Print Publication: 2023).