Zobrazeno 1 - 7 of 7 pro vyhledávání: '"huifang you"'
1
Akademický článek
Molecular optimization by capturing chemist’s intuition using deep neural networks
Autor: Jiazhen He, Huifang You, Emil Sandström, Eva Nittinger, Esben Jannik Bjerrum, Christian Tyrchan, Werngard Czechtizky, Ola Engkvist
Publikováno v: Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract A main challenge in drug discovery is finding molecules with a desirable balance of multiple properties. Here, we focus on the task of molecular optimization, where the goal is to optimize a given starting molecule towards desirable properti
Externí odkaz: https://doaj.org/article/563e14a2ef3a4c6c999213e40155f5e6
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2
Akademický článek
Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin
Autor: Lina Keutzer, Huifang You, Ali Farnoud, Joakim Nyberg, Sebastian G. Wicha, Gareth Maher-Edwards, Georgios Vlasakakis, Gita Khalili Moghaddam, Elin M. Svensson, Michael P. Menden, Ulrika S. H. Simonsson, on behalf of the UNITE4TB Consortium
Publikováno v: Pharmaceutics, Vol 14, Iss 8, p 1530 (2022)
Pharmacometrics (PM) and machine learning (ML) are both valuable for drug development to characterize pharmacokinetics (PK) and pharmacodynamics (PD). Pharmacokinetic/pharmacodynamic (PKPD) analysis using PM provides mechanistic insight into biologic
Externí odkaz: https://doaj.org/article/25a790d93aeb473e9a0152c76324f8f0
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3
PTEN Expression in Human Granulosa Cells Is Associated with Ovarian Responses and Clinical Outcomes in IVF
Autor: Rongfu Huang, Ming Li, Dianliang Lin, Weilin Peng, Huifang You, Peiya Wu, Xiaoyu Yang, Yi Jiang, Youzhu Li, Chengzhou Hua, Yanfang Huang, Jianfeng Yao, Yuanyuan Chen
Publikováno v: Reproductive Sciences. 28:1910-1921
The ovarian reserve determines the success of in vitro fertilization (IVF) and embryo transfer treatment. It predicts the ovarian response in controlled ovarian hyperstimulation cycles. Apoptosis in granulosa cells surrounding oocytes is important fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52c6bd9eb901029ec20bc1bdb12b49c5
https://doi.org/10.1007/s43032-020-00429-7
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5
Molecular optimization by capturing chemist’s intuition using deep neural networks
Autor: Eva Nittinger, Christian Tyrchan, Jiazhen He, huifang you, Esben Jannik Bjerrum, Ola Engkvist, Emil Sandström, Werngard Czechtizky
Publikováno v: Journal of Cheminformatics
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-17 (2021)
A main challenge in drug discovery is finding molecules with a desirable balance of multiple properties. Here, we focus on the task of molecular optimization, where the goal is to optimize a given starting molecule towards desirable properties. This
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355973b7e367c23df72e5117c3659170
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-182114
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6
PTEN Expression in Human Granulosa Cells Is Associated with Ovarian Responses and Clinical Outcomes in IVF
Autor: Jianfeng, Yao, Rongfu, Huang, Ming, Li, Yi, Jiang, Peiya, Wu, Youzhu, Li, Weilin, Peng, Chengzhou, Hua, Yanfang, Huang, Huifang, You, Yuanyuan, Chen, Dianliang, Lin, Xiaoyu, Yang
Publikováno v: Reproductive sciences (Thousand Oaks, Calif.). 28(7)
The ovarian reserve determines the success of in vitro fertilization (IVF) and embryo transfer treatment. It predicts the ovarian response in controlled ovarian hyperstimulation cycles. Apoptosis in granulosa cells surrounding oocytes is important fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::397dc1683051a2040ee4ab01c89f711e
https://pubmed.ncbi.nlm.nih.gov/34618344
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