Zobrazeno 1 - 10
of 856
pro vyhledávání: '"htt"'
Autor:
Tarcísio Fontenele de Brito, Maira Arruda Cardoso, Nazerke Atinbayeva, Ingrid Alexandre de Abreu Brito, Lucas Amaro da Costa, Nicola Iovino, Attilio Pane
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
IntroductionPiwi proteins and the associated Piwi-interacting RNAs (piRNAs) coordinate a surveillance system that protects the animal genome from DNA damage induced by transposable element (TE) mobilization. While the pathway has been described in de
Externí odkaz:
https://doaj.org/article/dda472065e044e07ad3f5eb3a1b54128
Autor:
Mathilde Louçã, Donya El Akrouti, Aude Lemesle, Morgane Louessard, Noëlle Dufour, Chloé Baroin, Aurore de la Fouchardière, Laurent Cotter, Hélène Jean-Jacques, Virginie Redeker, Anselme L. Perrier
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106630- (2024)
Despite growing descriptions of wild-type Huntingtin (wt-HTT) roles in both adult brain function and, more recently, development, several clinical trials are exploring HTT-lowering approaches that target both wt-HTT and the mutant isoform (mut-HTT) r
Externí odkaz:
https://doaj.org/article/014f66c687ef4b789460f73ea00cc84e
Autor:
Natalya V. Ponomareva, Sergey A. Klyushnikov, Natalia Abramycheva, Rodion N. Konovalov, Marina Krotenkova, Ekaterina Kolesnikova, Daria Malina, Gusel Urazgildeeva, Elena Kanavets, Andrey Mitrofanov, Vitaly Fokin, Evgeny Rogaev, Sergey N. Illarioshkin
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Externí odkaz:
https://doaj.org/article/a39be3539f344a7bab8f7489cbc44a98
Autor:
Rachel J. Harding, Carl Laflamme, Sara González Bolívar, Aled M. Edwards, Kathleen Southern, Rebeka Fanti, Riham Ayoubi, Charles Alende, Maryam Fotouhi, Renu Chandrasekaran
Publikováno v:
F1000Research, Vol 13 (2024)
Huntingtin encodes a 3144 amino acid protein, with a polyglutamine repeat tract at the N-terminus. Expansion of this repeat tract above a pathogenic threshold of 36 repeats is the causative mutation of Huntington's disease, a neurodegenerative disord
Externí odkaz:
https://doaj.org/article/4a5893b8570c4bb6a47f872075702b74
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract DNA mismatch repair (MMR) is thought to contribute to the onset and progression of Huntington disease (HD) by promoting somatic expansion of the pathogenic CAG nucleotide repeat in the huntingtin gene (HTT). Here we have studied constitution
Externí odkaz:
https://doaj.org/article/7e8f2306aea34783a1ca07f753e296b9
Publikováno v:
Indian Journal of Pathology and Microbiology, Vol 67, Iss 1, Pp 128-132 (2024)
Background: The incidence of thyroid tumor is increasing, and preoperative diagnosis of hyalinizing trabecular tumor (HTT) is difficult. Aim: To investigate the cytological features of HTT of the thyroid gland. Settings and Design: A retrospective ob
Externí odkaz:
https://doaj.org/article/e24b782e699e4dc8bb50e8e63025c8e8
Autor:
Mansi A. Parasrampuria, Adam A. White, Ramadevi Chilamkurthy, Adrian A. Pater, Fatima El-Azzouzi, Katy N. Ovington, Philip J. Jensik, Keith T. Gagnon
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102206- (2024)
Huntington’s disease (HD) is an incurable neurodegenerative disorder caused by genetic expansion of a CAG repeat sequence in one allele of the huntingtin (HTT) gene. Reducing expression of the mutant HTT (mutHTT) protein has remained a clear therap
Externí odkaz:
https://doaj.org/article/17ec7dc92aab4fd2b25cfea55d84c303
Autor:
Raffaella Bonavita, Rosaria Di Martino, Giuseppe Cortone, Antonello Prodomo, Mariagrazia Di Gennaro, Gianluca Scerra, Valentino Panico, Silvia Nuzzo, Marco Salvatore, Sarah V. Williams, Fulvia Vitale, Maria Gabriella Caporaso, Massimo D’Agostino, Francesca M. Pisani, Angeleen Fleming, Maurizio Renna
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Conformational diseases, such as Alzheimer’s, Parkinson’s and Huntington’s diseases as well as ataxias and fronto-temporal disorders, are part of common class of neurological disorders characterised by the aggregation and progressive accumulati
Externí odkaz:
https://doaj.org/article/500eda45a45f4427980a64fda0c9ab07
Publikováno v:
Sensors, Vol 24, Iss 17, p 5535 (2024)
The article addresses the energy consumption minimization problem in wireless powered communication networks (WPCNs) and proposes a time allocation scheme, named DaTA, which is based on the Different Target Simultaneous Wireless Information and Power
Externí odkaz:
https://doaj.org/article/53fd05e50417423c86b206801bb8acd4
Autor:
Huichun Tong, Tianqi Yang, Li Liu, Caijuan Li, Yize Sun, Qingqing Jia, Yiyang Qin, Laiqiang Chen, Xianxian Zhao, Gongke Zhou, Sen Yan, Xiao-Jiang Li, Shihua Li
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106291- (2023)
Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disease caused by a CAG repeat expansion in exon1 of the huntingtin gene (HTT). This expansion leads to the production of N-terminal mutant huntingtin protein (mHtt) that
Externí odkaz:
https://doaj.org/article/9ab2d0cc6f5849e19b6e2b87e74b3b12