Výsledky vyhledávání - "hot spot residues"

Akademický článek

Identifying promising druggable binding sites and their flexibility to target the receptor-binding domain of SARS-CoV-2 spike protein

Autor: M. Ghoula, S. Naceri, S. Sitruk, D. Flatters, G. Moroy, A.C. Camproux

Publikováno v: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2339-2351 (2023)

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for viral infection. The interaction of its receptor-binding domain (RBD) with the human angiotensin-converting enzyme 2 (ACE2) protein is required for the v

Externí odkaz: https://doaj.org/article/375450ddc34746d4a40d40a0fec54687

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Akademický článek

Analyses on clustering of the conserved residues at protein-RNA interfaces and its application in binding site identification

Autor: Zhen Yang, Xueqing Deng, Yang Liu, Weikang Gong, Chunhua Li

Publikováno v: BMC Bioinformatics, Vol 21, Iss 1, Pp 1-14 (2020)

Abstract Background The maintenance of protein structural stability requires the cooperativity among spatially neighboring residues. Previous studies have shown that conserved residues tend to occur clustered together within enzyme active sites and p

Externí odkaz: https://doaj.org/article/e058e9c9cdd042e7ae6dbc1940c79efd

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Akademický článek

Docking-based identification of small-molecule binding sites at protein-protein interfaces

Autor: Mireia Rosell, Juan Fernández-Recio

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 3750-3761 (2020)

Protein-protein interactions play an essential role in many biological processes, and their perturbation is a major cause of disease. The use of small molecules to modulate them is attracting increased attention, but protein interfaces generally do n

Externí odkaz: https://doaj.org/article/9148bbdc7ed94273bda14907c8aa45f4

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Akademický článek

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Akademický článek

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Akademický článek

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Variants in the NPC1 Gene in Egyptian Patients with Niemann-Pick Type C

Autor: Maha S. Zaki, Magda F. Mohamed, Ekram Fateen, Asmaa F. Abdel-aleem, Heba A. Hassan, Mona L. Essawi, M. A. Badawy

Publikováno v: Open Access Macedonian Journal of Medical Sciences, Vol 8, Iss A (2020)

BACKGROUND: Niemann-Pick disease type C (NPC) is a rare, autosomal recessive, progressive neuro-visceraldisease caused by biallelic mutations in either NPC1gene (95% of cases) or NPC2 gene. AIM: This caseseries study aimed at the molecular analysis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca3b90f3b67dcc3e4be53c29f7d2a91
https://doi.org/10.3889/oamjms.2020.4626

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Docking-based identification of small-molecule binding sites at protein-protein interfaces

Autor: Juan Fernández-Recio, Mireia Rosell

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 3750-3761 (2020)
RIUR. Repositorio Institucional de la Universidad de La Rioja
Computational and Structural Biotechnology Journal

Graphical abstract
Protein-protein interactions play an essential role in many biological processes, and their perturbation is a major cause of disease. The use of small molecules to modulate them is attracting increased attention, but protein i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2149a0b4781a4a081c40c545c497bde
https://doi.org/10.1016/j.csbj.2020.11.029

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A stepwise mutagenesis approach using histidine and acidic amino acid to engineer highly pH-dependent protein switches

Autor: Wenjun Zou, Chuncui Huang, Qing Sun, Keli Zhao, Huanyu Gao, Rong Su, Yan Li

Publikováno v: 3 Biotech

Antibody-based drugs can be highly toxic, because they target normal tissue as well as tumor tissue. The pH value of the extracellular microenvironments around tumor tissues is lower than that of normal tissues. Therefore, antibodies that engage in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e009db234b8dd3ea93f49ea9c8f5d201
http://europepmc.org/articles/PMC8686790

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Effective binding to protein antigens by antibodies from antibody libraries designed with enhanced protein recognition propensities

Autor: Ing-Chien Chen, Tung Chao-Ping, Hung-Pin Peng, Kuo Wei-Ying, Jhih-Wei Jian, Yu Chung-Ming, Chiu Yi-Kai, An-Suei Yang, Yueh-Liang Tsou, Hong-Sen Chen, Hung-Ju Hsu

Publikováno v: mAbs

Antibodies provide immune protection by recognizing antigens of diverse chemical properties, but elucidating the amino acid sequence-function relationships underlying the specificity and affinity of antibody-antigen interactions remains challenging.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde0af14b3ae4daec1c789ae8710bc94
http://europepmc.org/articles/PMC6380391

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