Výsledky vyhledávání - "host-directed therapies"

Akademický článek

Targeting and activation of macrophages in leishmaniasis. A focus on iron oxide nanoparticles

Autor: Carmen Palomino-Cano, Esther Moreno, Juan M. Irache, Socorro Espuelas

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Macrophages play a pivotal role as host cells for Leishmania parasites, displaying a notable functional adaptability ranging from the proinflammatory, leishmanicidal M1 phenotype to the anti-inflammatory, parasite-permissive M2 phenotype. While macro

Externí odkaz: https://doaj.org/article/f6a25dfb8ee44daa8d9c1f83552406dc

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Akademický článek

Next-generation treatments: Immunotherapy and advanced therapies for COVID-19

Autor: Jenny Andrea Arevalo-Romero, Sandra M. Chingaté-López, Bernardo Armando Camacho, Carlos Javier Alméciga-Díaz, Cesar A. Ramirez-Segura

Publikováno v: Heliyon, Vol 10, Iss 5, Pp e26423- (2024)

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in 2019 following prior outbreaks of coronaviruses like SARS and MERS in recent decades, underscoring their high potential of infectivity in humans

Externí odkaz: https://doaj.org/article/e9ae094f206b4d5c901d4cd4bf563ed6

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Akademický článek

SMA-TB: study protocol for the phase 2b randomized double-blind, placebo-controlled trial to estimate the potential efficacy and safety of two repurposed drugs, acetylsalicylic acid and ibuprofen, for use as adjunct therapy added to, and compared with, the standard WHO recommended TB regimen

Autor: Lilibeth Arias, Kennedy Otwombe, Ziyaad Waja, Nestani Tukvadze, Tamta Korinteli, Tumelo Moloantoa, Kaori L Fonseca, Natasha Pillay, Thabiso Seiphetlo, Dan Ouchi-Vernet, Adrian Siles, Lidia Carabias, Carles Quiñones, Sergo Vashakidze, Neil Martinson, Cristina Vilaplana

Publikováno v: Trials, Vol 24, Iss 1, Pp 1-16 (2023)

Abstract Background The duration and regimen of tuberculosis (TB) treatment is currently based predominantly on whether the M. tuberculosis (Mtb) strain is drug-sensitive (DS) or multidrug-resistant (MDR) with doses adjusted by patients’ weight onl

Externí odkaz: https://doaj.org/article/84f87ca4e04d4ec18d56201863085e5a

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Akademický článek

Differential Regulation of TFEB-Induced Autophagy during Mtb Infection and Starvation

Autor: Richa Dwivedi, Piyush Baindara

Publikováno v: Microorganisms, Vol 11, Iss 12, p 2944 (2023)

Through the promotion of phagolysosome formation, autophagy has emerged as a crucial mechanism to eradicate intracellular Mycobacterium tuberculosis (Mtb). A cell-autonomous host defense mechanism called lysosome biogenesis and autophagy transports c

Externí odkaz: https://doaj.org/article/2ede15ad5c14475091e1e48dcb4bded5

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Akademický článek

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Akademický článek

Validation of proteins associated with pathological damage in human tuberculosis granulomas: study protocol [version 1; peer review: 2 approved]

Autor: Jessica More, Denelle Moodley, Mohlopheni J Marakalala, Kerishka Rajkumar-Bhugeloo, Thabo Mpotje

Publikováno v: Wellcome Open Research, Vol 8 (2023)

The presence of the Tuberculosis (TB) disease-causing pathogen, Mycobacterium Tuberculosis (Mtb), induces the development of a pathological feature termed granuloma, which the host uses to contain the bacteria. However, the granuloma may dissociate r

Externí odkaz: https://doaj.org/article/042e9a9a84a747abb9b45b9a0c0d4b5b

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Akademický článek

Modulation of Cystatin F in Human Macrophages Impacts Cathepsin-Driven Killing of Multidrug-Resistant Mycobacterium tuberculosis

Autor: Manoj Mandal, David Pires, Maria João Catalão, José Miguel Azevedo-Pereira, Elsa Anes

Publikováno v: Microorganisms, Vol 11, Iss 7, p 1861 (2023)

Tuberculosis (TB) treatment relies primarily on 70-year-old drugs, and prophylaxis suffers from the lack of an effective vaccine. Among the 10 million people exhibiting disease symptoms yearly, 450,000 have multidrug or extensively drug-resistant (MD

Externí odkaz: https://doaj.org/article/2b6bdd2aff4f4531a9716597f03217b6

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Akademický článek

Sildenafil, a Type-5 Phosphodiesterase Inhibitor, Fails to Reverse Myeloid-Derived Suppressor Cell-Mediated T Cell Suppression in Cells Isolated From Tuberculosis Patients

Autor: Vinzeigh N. Leukes, Stephanus T. Malherbe, Andriette Hiemstra, Leigh A. Kotze, Kelly Roos, Alana Keyser, Dalene De Swardt, Andrea Gutschmidt, Gerhard Walzl, Nelita du Plessis

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Successful TB treatment is hampered by increasing resistance to the two most effective first-line anti-TB drugs, namely isoniazid and rifampicin, thus innovative therapies focused on host processes, termed host-directed therapies (HDTs), are promisin

Externí odkaz: https://doaj.org/article/c412de5fcccf443887d1b48438fa8307

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Akademický článek

Viral-Host Dependency Factors as Therapeutic Targets to Overcome Antiviral Drug-Resistance: A Focus on Innate Immune Modulation

Autor: Roger Badia, Edurne Garcia-Vidal, Ester Ballana

Publikováno v: Frontiers in Virology, Vol 2 (2022)

The development of antiviral drugs, has provided enormous achievements in our recent history in the fight against viral infections. To date, most of the approved antiviral drugs target virus-encoded proteins to achieve direct antiviral activity. None

Externí odkaz: https://doaj.org/article/b1c94ac654a34db2957d01737da61dc8

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