Zobrazeno 1 - 10
of 472
pro vyhledávání: '"host shutoff"'
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract During viral infection there is dynamic interplay between the virus and the host to regulate gene expression. In many cases, the host induces the expression of antiviral genes to combat infection, while the virus uses “host shut-off” sys
Externí odkaz:
https://doaj.org/article/27febcd34e5549a295e9f3c410559f9d
Autor:
Soraya I. Shehata, Roy Parker
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 444-456 (2023)
Nsp1 is a SARS-CoV-2 host shutoff factor that both represses cellular translation and promotes host RNA decay. However, it is unclear how these two activities are connected and interact with normal translation processes. Here, we performed mutational
Externí odkaz:
https://doaj.org/article/fd44f604b4b24256a0db24c3e1d2464c
Autor:
Xinxin Niu, Jinze Han, Mengmeng Huang, Guodong Wang, Yulong Zhang, Wenying Zhang, Hangbo Yu, Mengmeng Xu, Kai Li, Li Gao, Suyan Wang, Yuntong Chen, Hongyu Cui, Yanping Zhang, Changjun Liu, Xiaomei Wang, Yulong Gao, Xiaole Qi
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Viruses have evolved intricate mechanisms to evade host antiviral responses and exploit cellular resources by manipulating the expression profile of host genes. During infection, viruses encode proteins with shutoff activity to globally inhi
Externí odkaz:
https://doaj.org/article/d9871c45d9d14cfd9828ea7a9cfc2cda
Akademický článek
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Akademický článek
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Akademický článek
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Publikováno v:
Viruses, Vol 15, Iss 6, p 1283 (2023)
African swine fever is a viral disease of swine caused by the African swine fever virus (ASFV). Currently, ASFV is spreading over the Eurasian continent and threatening global pig husbandry. One viral strategy to undermine an efficient host cell resp
Externí odkaz:
https://doaj.org/article/087481cfb3dd42dda7d64319767ec45e
Autor:
Tal Fisher, Avi Gluck, Krishna Narayanan, Makoto Kuroda, Aharon Nachshon, Jason C. Hsu, Peter J. Halfmann, Yfat Yahalom-Ronen, Hadas Tamir, Yaara Finkel, Michal Schwartz, Shay Weiss, Chien-Te K. Tseng, Tomer Israely, Nir Paran, Yoshihiro Kawaoka, Shinji Makino, Noam Stern-Ginossar
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110954- (2022)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to shutoff of protein synthesis, and nsp1, a central shutoff factor in coronaviruses, inhibits cellular mRNA translation. However, the diverse molecular mechanisms employed b
Externí odkaz:
https://doaj.org/article/d7b13beba8354d0e9b3f2e07d1ad3167
Autor:
Tianqiong He, Mingshu Wang, Anchun Cheng, Qiao Yang, Ying Wu, Renyong Jia, Mafeng Liu, Dekang Zhu, Shun Chen, Shaqiu Zhang, Xin-Xin Zhao, Juan Huang, Di Sun, Sai Mao, Xuming Ou, Yin Wang, Zhiwen Xu, Zhengli Chen, Lin Zhu, Qihui Luo, Yunya Liu, Yanling Yu, Ling Zhang, Bin Tian, Leichang Pan, Mujeeb Ur Rehman, Xiaoyue Chen
Publikováno v:
Virology Journal, Vol 17, Iss 1, Pp 1-11 (2020)
Abstract Background Host shutoff refers to the widespread downregulation of host gene expression and has emerged as a key process that facilitates the reallocation of cellular resources for viral replication and evasion of host antiviral immune respo
Externí odkaz:
https://doaj.org/article/c3cefe4a4d834a038e83cff482b80dd4
Autor:
Alejandro Casco, Eric Johannsen
Publikováno v:
Viruses, Vol 15, Iss 3, p 726 (2023)
During reactivation from latency, gammaherpesviruses radically restructure their host cell to produce virion particles. To achieve this and thwart cellular defenses, they induce rapid degradation of cytoplasmic mRNAs, suppressing host gene expression
Externí odkaz:
https://doaj.org/article/8f6b21fb879545c9bf600a2653d02dcd