Epigenetic targeting of transposon relics: beating the dead horses of the genome?

Autor: Iris Sammarco, Janto Pieters, Susnata Salony, Izabela Toman, Grygoriy Zolotarov, Clément Lafon Placette

Publikováno v: Epigenetics, Vol 17, Iss 11, Pp 1331-1344 (2022)

Transposable elements (TEs) have been seen as selfish genetic elements that can propagate in a host genome. Their propagation success is however hindered by a combination of mechanisms such as mutations, selection, and their epigenetic silencing by t

Externí odkaz: https://doaj.org/article/cae993bcdd524bd4a292855343068643

Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males

Autor: Margherita Baldassarri, Nicola Picchiotti, Francesca Fava, Chiara Fallerini, Elisa Benetti, Sergio Daga, Floriana Valentino, Gabriella Doddato, Simone Furini, Annarita Giliberti, Rossella Tita, Sara Amitrano, Mirella Bruttini, Susanna Croci, Ilaria Meloni, Anna Maria Pinto, Nicola Iuso, Chiara Gabbi, Francesca Sciarra, Mary Anna Venneri, Marco Gori, Maurizio Sanarico, Francis P. Crawley, Uberto Pagotto, Flaminia Fanelli, Marco Mezzullo, Elena Dominguez-Garrido, Laura Planas-Serra, Agatha Schlüter, Roger Colobran, Pere Soler-Palacin, Pablo Lapunzina, Jair Tenorio, Aurora Pujol, Maria Grazia Castagna, Marco Marcelli, Andrea M. Isidori, Alessandra Renieri, Elisa Frullanti, Francesca Mari

Publikováno v: EBioMedicine, Vol 65, Iss , Pp 103246- (2021)

Background: While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. Methods: We compared poly-amino acids variability from WES d

Externí odkaz: https://doaj.org/article/755194159e9949cfb57fea4a9a65f5ea

An Information-Based Approach for Mediation Analysis on High-Dimensional Metagenomic Data

Autor: Kyle M. Carter, Meng Lu, Hongmei Jiang, Lingling An

Publikováno v: Frontiers in Genetics, Vol 11 (2020)

The human microbiome plays a critical role in the development of gut-related illnesses such as inflammatory bowel disease and clinical pouchitis. A mediation model can be used to describe the interaction between host gene expression, the gut microbio

Externí odkaz: https://doaj.org/article/6b17797af0a54d7481750b362b9ee94f

Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

Autor: Monique Nijhuis, Steven G. Deeks, Richard Dunham, Marein A. W. P. de Jong, Marein de Jong, Thanyawee Puthanakit, Mirko Paiardini, Santiago Perez Patrigeon, Krista L. Dong, Jan van Lunzen, Luke Jasenosky, Jessica Salzwedel, Simon Collins, Katharine J. Bar, Frank Mardarelli, Jeffrey T. Safrit, Jeremy Sugarman, Alex Schneider, Nancie M. Archin, Zaza M. Ndhlovu, Joel N. Blankson, Zabrina L. Brumme, Hans-Peter Kiem, Gaerolwe Masheto, Beatriz Mothe, Karine Dubé, Katherine Luzuriaga, Jennifer Power, Sarah Fidler, Richard Jefferys, Fu Sheng Wang, Jeff Taylor, Kumitaa Theva Das, Boro Dropulic, Kai Deng, Devi SenGupta, Sharon Lewin, Marina Caskey, Susana T. Valente, Siegfried Schwarze, Nicolas Chomont, R. Brad Jones, Ole S. Søgaard, Paula M. Cannon, Olivier Lambotte, Edward Nelson Kankaka, Gabriela Turk, Christina Antoniadi, Udom Likhitwonnawut, Caroline T. Tiemessen, Pablo Tebas, Rosanne Lamplough, Cissy Kityo, Fernanda Heloise Côrtes, Melannie Ott, Rose Nabatanzi, Oguzhan Latif Nuh, Mitch Matoga, Linos Vandekerckhove, J. Victor Garcia, Thumbi Ndung'u, Bonnie J. Howell, Aurelio Orta-Resendiz, Ricardo Sobhie Diaz, Michael Louella, Ann Chahroudi, Deborah Persaud, Stephan Dressler, Josephine Nabukenya, Sharon R Lewin

Publikováno v: Nature Medicine. 27:2085-2098

Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. HIV can integrate in the host genome and persist for the life span of the infected cell. These latently infected cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b45d4a1ed300ed64c27c2b6dc382ca1a
https://doi.org/10.1038/s41591-021-01590-5

Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group

Autor: J. J. Bakhuizen, Marc Tischkowitz, Karin van der Tuin, Helen Hanson, Fiona Lalloo, Marjolijn C.J. Jongmans, Karin Wadt

Publikováno v: Familial Cancer
Bakhuizen, J J, Hanson, H, van der Tuin, K, Lalloo, F, Tischkowitz, M, Wadt, K, Jongmans, M C J, SIOPE Host Genome Working Group, CanGene-CanVar Clinical Guideline Working Group & Expert Network Members 2021, ' Surveillance recommendations for DICER1 pathogenic variant carriers : a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group ', Familial Cancer, vol. 20, no. 4, pp. 337-348 . https://doi.org/10.1007/s10689-021-00264-y

DICER1 syndrome is a rare genetic disorder that predisposes to a wide spectrum of tumors. Developing surveillance protocols for this syndrome is challenging because uncertainty exists about the clinical efficacy of surveillance, and appraisal of pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd7878b91193786d1ada7d9e84ed224
http://europepmc.org/articles/PMC8484187