Zobrazeno 1 - 10
of 1 138
pro vyhledávání: '"host‐directed therapy"'
Autor:
Yilin Liu, Jiajun Wang, Jiayi Yang, Jiaojiao Xia, Jiaqi Yu, Dongsheng Chen, Yuhe Huang, Fen Yang, Yongdui Ruan, Jun-Fa Xu, Jiang Pi
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Tuberculosis (TB), induced by Mycobacterium tuberculosis (Mtb) infection, remains a major public health issue worldwide. Mtb has developed complicated strategies to inhibit the immunological clearance of host cells, which significantly promo
Externí odkaz:
https://doaj.org/article/66759fb8248b4faa9c42a7953d5fb4dc
Publikováno v:
Frontiers in Virology, Vol 4 (2024)
Millions of people have died and a worldwide economic catastrophe has been brought on by the coronavirus disease 2019 (COVID-19) pandemic. Infections caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may presently be treated
Externí odkaz:
https://doaj.org/article/3094a2a80afc48ac84f44574b0180c6d
Autor:
Saeid Najafi-Fard, Chiara Farroni, Linda Petrone, Anna Maria Gerarda Altera, Andrea Salmi, Valentina Vanini, Gilda Cuzzi, Tonino Alonzi, Emanuele Nicastri, Gina Gualano, Fabrizio Palmieri, Mauro Piacentini, Delia Goletti
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectiveCysteamine, a drug approved to treat cystinosis, has been proposed as a host-directed therapy for M. tuberculosis (Mtb) and SARS-CoV-2. The impact of cysteamine on the immune responses has not been fully investigated. We aimed to in vitro ev
Externí odkaz:
https://doaj.org/article/7a8c9c9781b74e85a64bf793db272ef8
Autor:
Shuhao Fan, Daina Zhao, Jiajun Wang, Yuhe Ma, Dongsheng Chen, Yuhe Huang, Tangxin Zhang, Yilin Liu, Jiaojiao Xia, Xueqin Huang, Yujia Lu, Yongdui Ruan, Jun-Fa Xu, Ling Shen, Fen Yang, Jiang Pi
Publikováno v:
Materials Today Bio, Vol 28, Iss , Pp 101232- (2024)
Tuberculosis (TB) remains the leading cause of deaths among infectious diseases worldwide. Cutaneous Tuberculosis (CTB), caused by Mycobacterium tuberculosis (Mtb) infection in the skin, is still a harmful public health issue that requires more effec
Externí odkaz:
https://doaj.org/article/eb7fb139a3e3440eac584584fe818046
Autor:
Tommaso Olimpieri, Noemi Poerio, Greta Ponsecchi, Gustavo Di Lallo, Marco Maria D’Andrea, Maurizio Fraziano
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Mycobacterium abscessus (Mab) is an opportunistic nontuberculous mycobacterium responsible of difficult-to-treat pulmonary infections in vulnerable patients, such as those suffering from Cystic Fibrosis (CF), where it represents a major cause of morb
Externí odkaz:
https://doaj.org/article/afdd88761c754ab4a8779ea5fe81ed85
Autor:
Clio Häring, Josefine Schroeder, Johannes Jungwirth, Bettina Löffler, Andreas Henke, Beatrice Engert, Christina Ehrhardt
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionTreatment of influenza A virus infections is currently limited to few direct acting antiviral substances. Repurposing other established pharmaceuticals as antivirals could aid in improving treatment options.MethodsThis study investigates
Externí odkaz:
https://doaj.org/article/15d0a6b4f4504e7989c9afeca142aa76
Autor:
Gül Kilinç, Ralf Boland, Matthias T. Heemskerk, Herman P. Spaink, Mariëlle C. Haks, Michiel van der Vaart, Tom H. M. Ottenhoff, Annemarie H. Meijer, Anno Saris
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT Mycobacterium tuberculosis (Mtb) as well as nontuberculous mycobacteria are intracellular pathogens whose treatment is extensive and increasingly impaired due to the rise of mycobacterial drug resistance. The loss of antibiotic efficacy has
Externí odkaz:
https://doaj.org/article/2939a79ee24140a7a75c5c4c4f1addde
Autor:
Ximeng Zhang, Guanggui Ding, Xirui Yang, Hailin Lu, Yuzhong Xu, Yunlong Hu, Song Liu, Huihua Zhang, Kaisong Huang, Guofang Deng, Taosheng Ye, Qing Yu, Yi Cai, Shuixiang Xie, Wenfei Wang, Xinchun Chen
Publikováno v:
mSphere, Vol 9, Iss 7 (2024)
ABSTRACT Myriocin is an inhibitor of de novo synthesis of sphingolipids and ceramides. In this research, we showed myriocin could significantly reduce Mtb burden and histopathological inflammation in mice. However, the underlying mechanism remains un
Externí odkaz:
https://doaj.org/article/8e9fd19ccb264edfa58348ed523ba9f5
Autor:
Fu L, Wang W, Xiong J, Zhang P, Li H, Zhang X, Liang H, Yang Q, Wang Z, Chen X, Deng G, Cai Y, Tang S
Publikováno v:
Infection and Drug Resistance, Vol Volume 17, Pp 595-604 (2024)
Liang Fu,1,2,* Wenfei Wang,2,3,* Juan Xiong,4,* Peize Zhang,2 Hui Li,2 Xilin Zhang,5 Hancheng Liang,6 Qianting Yang,2 Zhaoqin Wang,2 Xinchun Chen,3 Guofang Deng,2 Yi Cai,3 Shenjie Tang1 1Beijing Chest Hospital, Capital Medical University,
Externí odkaz:
https://doaj.org/article/5324d15952954d2dbd7ccf7430c04323
Autor:
Blanca Lorente-Torres, Jesús Llano-Verdeja, Pablo Castañera, Helena Á. Ferrero, Sergio Fernández-Martínez, Farzaneh Javadimarand, Luis M. Mateos, Michal Letek, Álvaro Mourenza
Publikováno v:
Antibiotics, Vol 13, Iss 9, p 834 (2024)
Intracellular bacterial pathogens pose significant public health challenges due to their ability to evade immune defenses and conventional antibiotics. Drug repurposing has recently been explored as a strategy to discover new therapeutic uses for est
Externí odkaz:
https://doaj.org/article/681bdc94449d4ee380f010fa76428e27