Zobrazeno 1 - 10
of 172
pro vyhledávání: '"homology-directed repair (HDR)"'
Autor:
Alessandro Umbach, Giulia Maule, Eyemen Kheir, Alessandro Cutarelli, Marika Foglia, Luca Guarrera, Luca L. Fava, Luciano Conti, Enrico Garattini, Mineko Terao, Anna Cereseto
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Background Cornelia de Lange syndrome (CdLS) is a rare multisystem genetic disorder which is caused by genetic defects involving the Nipped-B-like protein (NIPBL) gene in the majority of clinical cases (60–70%). Currently, there are no spe
Externí odkaz:
https://doaj.org/article/a3317733e436485fa7844778aed951b2
Autor:
Wei Wen, Zi-Jun Quan, Si-Ang Li, Zhi-Xue Yang, Ya-Wen Fu, Feng Zhang, Guo-Hua Li, Mei Zhao, Meng-Di Yin, Jing Xu, Jian-Ping Zhang, Tao Cheng, Xiao-Bing Zhang
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)
Abstract Background After repairing double-strand breaks (DSBs) caused by CRISPR-Cas9 cleavage, genomic damage, such as large deletions, may have pathogenic consequences. Results We show that large deletions are ubiquitous but are dependent on editin
Externí odkaz:
https://doaj.org/article/df51a80f1e864427bde4af68b40acd79
Autor:
Igor Petković, Johannes Bischof, Thomas Kocher, Oliver Patrick March, Bernadette Liemberger, Stefan Hainzl, Dirk Strunk, Anna Maria Raninger, Heide-Marie Binder, Julia Reichelt, Christina Guttmann-Gruber, Verena Wally, Josefina Piñón Hofbauer, Johann Wolfgang Bauer, Ulrich Koller
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundEpidermolysis bullosa (EB), a severe genetic disorder characterized by blister formation in skin, is caused by mutations in genes encoding dermal-epidermal junction proteins that function to hold the skin layers together. CRISPR/Cas9-induce
Externí odkaz:
https://doaj.org/article/e558e28c793c49b181a16d8c359f5acf
Autor:
Inga Usher, Lorena Ligammari, Sara Ahrabi, Emily Hepburn, Calum Connolly, Gareth L. Bond, Adrienne M. Flanagan, Lucia Cottone
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
CRISPR/Cas9, base editors and prime editors comprise the contemporary genome editing toolbox. Many studies have optimized the use of CRISPR/Cas9, as the original CRISPR genome editing system, in substituting single nucleotides by homology directed re
Externí odkaz:
https://doaj.org/article/b020ee5e03d54743b885b3062783fbdb
Autor:
Jeremy M. Kelm, Amirreza Samarbakhsh, Athira Pillai, Pamela S. VanderVere-Carozza, Hariprasad Aruri, Deepti S. Pandey, Katherine S. Pawelczak, John J. Turchi, Navnath S. Gavande
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The vast majority of cancer patients receive DNA-damaging drugs or ionizing radiation (IR) during their course of treatment, yet the efficacy of these therapies is tempered by DNA repair and DNA damage response (DDR) pathways. Aberrations in DNA repa
Externí odkaz:
https://doaj.org/article/74a34493f8cf45abaafceb2411d093e9
Autor:
Stefan H. Scheller, Yasmine Rashad, Fayez M. Saleh, Kurtis A. Willingham, Antonia Reilich, Dong Lin, Reza Izadpanah, Eckhard U. Alt, Stephen E. Braun
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Transplanting HIV-1 positive patients with hematopoietic stem cells homozygous for a 32 bp deletion in the chemokine receptor type 5 (CCR5) gene resulted in a loss of detectable HIV-1, suggesting genetically disrupting CCR5 is a promising approach fo
Externí odkaz:
https://doaj.org/article/cdd5d9185f5b4533babba21b5503c30e
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 765-773 (2020)
Duchenne muscular dystrophy (DMD) is a progressive myopathic disease caused by mutations in the gene encoding dystrophin protein that eventually leads to the exhaustion of myogenic progenitor cells (MPC). Autologous induced pluripotent stem cells (iP
Externí odkaz:
https://doaj.org/article/0105e12a1b094eb0bc5c0a06ab4bcc70
Publikováno v:
Rice, Vol 12, Iss 1, Pp 1-29 (2019)
Abstract Continuing crop domestication/redomestication and modification is a key determinant of the adaptation and fulfillment of the food requirements of an exploding global population under increasingly challenging conditions such as climate change
Externí odkaz:
https://doaj.org/article/0e55ba73e5f747aa93c8e7338dbdb7b8
Autor:
Qi Fang, Yoichi Shinkai
Publikováno v:
MethodsX, Vol 8, Iss , Pp 101365- (2021)
To study the biological function of uncharacterized proteins, specific antibodies are in high demand. However, the production of desirable antibodies such as highly specific or high affinity is not always successful. Furthermore, even if commercially
Externí odkaz:
https://doaj.org/article/2a232663821b40bc8ae940399cd4d098
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.