Zobrazeno 1 - 10
of 100
pro vyhledávání: '"homologous recombination deficiency (HRD)"'
Autor:
Jiayin Dong, Jing Ni, Jiahui Chen, Xuening Wang, Luxin Ye, Xia Xu, Wenwen Guo, Xiaoxiang Chen
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-11 (2024)
Abstract Purpose Ovarian cancer (OC) is characterized by a high recurrence rate, and homologous recombination deficiency (HRD) is an important biomarker in the clinical management of OC. We investigated the differences in clinical genomic profiles be
Externí odkaz:
https://doaj.org/article/a9eeb241b2574d93a2709661d4fdb479
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
ObjectiveTubo-ovarian carcinosarcomas are rare, extremely aggressive malignant tumors that contain both carcinomatous and sarcomatous components. Due to the disease’s rarity, developing an effective treatment strategy for ovarian carcinosarcomas ha
Externí odkaz:
https://doaj.org/article/c543d51d4c554ea58afc88347b1ee1d8
Autor:
Lin Dong, Lin Li, Linyan Zhu, Fei Xu, Rumeng Zhang, Qiushuang Li, Yong Zhu, Zhutian Zeng, Keshuo Ding
Publikováno v:
Biomolecules & Biomedicine (2024)
There remains ongoing debate regarding the association of homologous recombination deficiency (HRD) with patient survival across various malignancies, highlighting the need for a comprehensive understanding of HRD's role in different cancer types. Ba
Externí odkaz:
https://doaj.org/article/dd5f88c391234ca48d82318a6cc86245
Autor:
Dimitrios Zouzoulas, Dimitrios Tsolakidis, Panagiotis Tzitzis, Kimon Chatzistamatiou, Vasilis Theodoulidis, Iliana Sofianou, Grigoris Grimbizis, Eleni Timotheadou
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5230 (2024)
BRCA mutation and homologous recombination deficiency (HRD) are the criteria for the administration of PARP inhibitor (PARPi) maintenance therapy. It is known that PARPi efficacy is related to platinum sensitivity and that the latter can be demonstra
Externí odkaz:
https://doaj.org/article/6f4d51c493db429d9880a78227bc4017
Autor:
Takayuki Ueno, Shigehisa Kitano, Norikazu Masuda, Daiki Ikarashi, Makiko Yamashita, Tomohiro Chiba, Takayuki Kadoya, Hiroko Bando, Takashi Yamanaka, Shoichiro Ohtani, Shigenori Nagai, Takahiro Nakayama, Masato Takahashi, Shigehira Saji, Kenjiro Aogi, Ravi Velaga, Kosuke Kawaguchi, Satoshi Morita, Hironori Haga, Shinji Ohno, Masakazu Toi
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-10 (2022)
Abstract Background Triple-negative breast cancer (TNBC) is a biologically diverse disease, with characteristics such as homologous recombination deficiency (HRD), gene mutation, and immune reactions. Japan Breast Cancer Research Group 22 is a multic
Externí odkaz:
https://doaj.org/article/5711388d449949039bda369d7ffea37a
Autor:
Rodrigo Guarischi-Sousa, José Eduardo Kroll, Adriano Bonaldi, Paulo Marques Pierry, Darine Villela, Camila Alves Souza, Juliana Santos Silva, Matheus Carvalho Bürger, Felipe Azevedo Oliveira, Marcelo Gomes de Paula, Fabiana Marcelino Meliso, Luiz Gustavo de Almeida, Priscilla Morais Monfredini, Ana Gabriela de Oliveira, Fernanda Milanezi, Cristovam Scapulatempo-Neto, Guilherme Lopes Yamamoto
Publikováno v:
Diagnostics, Vol 13, Iss 21, p 3293 (2023)
Homologous recombination deficiency (HRD) has become an important prognostic and predictive biomarker for patients with high-grade serous ovarian cancer who may benefit from poly-ADP ribose polymerase inhibitors (PARPi) and platinum-based therapies.
Externí odkaz:
https://doaj.org/article/4c4d7f2f44b64e2682d2576a31490d4d
Akademický článek
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Autor:
Maria Valeria Freire, Marie Martin, Romain Thissen, Cédric Van Marcke, Karin Segers, Edith Sépulchre, Natacha Leroi, Céline Lété, Corinne Fasquelle, Jean Radermacher, Yeter Gokburun, Joelle Collignon, Anne Sacré, Claire Josse, Leonor Palmeira, Vincent Bours
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectiveThe link between BRCA1 and homologous recombination deficiency (HRD) in cancer has gained importance with the emergence of new targeted cancer treatments, while the available data on the role of the gene in colorectal cancer (CRC) remain con
Externí odkaz:
https://doaj.org/article/fae6e8007fee405da51b4518542436e3
Akademický článek
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