Zobrazeno 1 - 2
of 2
pro vyhledávání: '"homogenous TCR expreession"'
Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy
Autor:
Müller, Thomas R. 1, 2, Jarosch, Sebastian 1, Hammel, Monika 1, Leube, Justin 1, Grassmann, Simon 1, 3, Bernard, Bettina 1, Effenberger, Manuel 1, Andrä, Immanuel 1, Chaudhry, M. Zeeshan 4, 5, Käuferle, Theresa 2, 6, Malo, Antje 7, Cicin-Sain, Luka 4, 5, Steinberger, Peter 8, Feuchtinger, Tobias 2, 6, Protzer, Ulrike 2, 7, Schumann, Kathrin 1, 9, Neuenhahn, Michael 1, 2, Schober, Kilian 1, 10, ∗, Busch, Dirk H. 1, 2, 9, 10, 11, ∗∗
Publikováno v:
In Cell Reports Medicine 17 August 2021 2(8)
Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy
Autor:
Antje Malo, Luka Cicin-Sain, Michael Neuenhahn, Sebastian Jarosch, Dirk H. Busch, Ulrike Protzer, Kilian Schober, Justin Leube, Simon Grassmann, Kathrin Schumann, Manuel Effenberger, T. Müller, Monika Hammel, M. Zeeshan Chaudhry, Bettina Bernard, Immanuel Andrä, Peter Steinberger, Tobias Feuchtinger, Theresa Käuferle
Publikováno v:
Cell Reports Medicine
Cell reports. Medicine
United States
Cell reports. Medicine
United States
Summary Adoptive transfer of T cells expressing a transgenic T cell receptor (TCR) has the potential to revolutionize immunotherapy of infectious diseases and cancer. However, the generation of defined TCR-transgenic T cell medicinal products with pr