Zobrazeno 1 - 10
of 1 131
pro vyhledávání: '"homeostatic proliferation"'
Publikováno v:
Journal of Biological Dynamics, Vol 16, Iss 1, Pp 713-732 (2022)
Latently infected CD[Formula: see text] T cells represent one of the major obstacles to HIV eradication even after receiving prolonged highly active anti-retroviral therapy (HAART). Long-term use of HAART causes the emergence of drug-resistant virus
Externí odkaz:
https://doaj.org/article/3569a5484713478a8009b7ab919f4aa0
Autor:
Qing Min, Krisztian Csomos, Yaxuan Li, Lulu Dong, Ziying Hu, Xin Meng, Meiping Yu, Jolan E. Walter, Ji-Yang Wang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mutations in the recombination activating gene 1 (RAG1) and RAG2 in humans are associated with a broad spectrum of clinical phenotypes, from severe combined immunodeficiency to immune dysregulation. Partial (hypomorphic) RAG deficiency (pRD) in parti
Externí odkaz:
https://doaj.org/article/2c3714d87b45462698adacb97af335af
Autor:
D. V. Shevyrev, V. A. Kozlov
Publikováno v:
Медицинская иммунология, Vol 23, Iss 4, Pp 671-676 (2021)
Cytokines IL-7 and IL-15 are the most important humoral factors providing T-conventional cell pool reconstitution during homeostatic proliferation caused by lymphopenia. However, whether these cytokines can provide homeostatic maintenance and prolife
Externí odkaz:
https://doaj.org/article/aa1fb03620814c6e89f17c513848117f
Publikováno v:
Медицинская иммунология, Vol 23, Iss 4, Pp 725-730 (2021)
Much attention of researchers is directed to study the role of factors of homeostatic proliferation in the pathogenesis of autoimmune diseases, however, the effect of IL-7 and IL-15 on the phenotype of naive T cells has not yet been sufficiently inve
Externí odkaz:
https://doaj.org/article/c2433fc6dc3949598c935ed520c9f335
Akademický článek
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Autor:
V. A. Kozlov
Publikováno v:
Инфекция и иммунитет, Vol 9, Iss 5-6, Pp 629-638 (2020)
There is no doubt that infectious agents and host undergo multilayered yet not fully understood interactions. This is primarily due to at least mechanisms resulting in chronic course of infectious process. Acute infection proceeds in parallel with pr
Externí odkaz:
https://doaj.org/article/7a6208ec2f7f457aacb530a247eaa1db
Publikováno v:
Virology Journal, Vol 17, Iss 1, Pp 1-13 (2020)
Abstract Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral load to clinically undetectable levels, viral rebound inevitably occurs once ART is interrupted. HIV-1-infected cells can undergo clonal expansion, a
Externí odkaz:
https://doaj.org/article/e8c144a216c24bdebc8d7e893c6fc945
Autor:
Isaac J Jensen, Xiang Li, Patrick W McGonagill, Qiang Shan, Micaela G Fosdick, Mikaela M Tremblay, Jon CD Houtman, Hai-Hui Xue, Thomas S Griffith, Weiqun Peng, Vladimir P Badovinac
Publikováno v:
eLife, Vol 10 (2021)
The global health burden due to sepsis and the associated cytokine storm is substantial. While early intervention has improved survival during the cytokine storm, those that survive can enter a state of chronic immunoparalysis defined by transient ly
Externí odkaz:
https://doaj.org/article/96b44fa8eb9b49b08945650bd27d9fdc
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In this review, we described the structure and organization of antigen-recognizing repertoires of B and T cells from the standpoint of modern immunology. We summarized the latest advances in bioinformatics analysis of sequencing data from T and B cel
Externí odkaz:
https://doaj.org/article/85075e90d30c419ca2f0a0f769cb1a2b
Akademický článek
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